Entry of EGF into brain is rapid and saturable

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

1983 • 3,439 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Murine tumor necrosis factor alpha is transported from blood to brain in the mouse

1993 • 561 citations

Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes

1983 • 510 citations

Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism.

1991 • 449 citations

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.

1994 • 441 citations

Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies.

1983 • 327 citations

Peptides and the blood-brain barrier: Lipophilicity as a predictor of permeability

1985 • 297 citations

Peptides and the blood–brain barrier

2015 • 250 citations

A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.

1995 • 216 citations

Permeability of the blood–brain barrier to neurotrophins

1998 • 173 citations

Passage of pituitary adenylate cyclase activating polypeptide1-27 and pituitary adenylate cyclase activating polypeptide1-38 across the blood-brain barrier.

1993 • 168 citations

Effect of Diabetes Mellitus on the Permeability of the Blood–Brain Barrier to Insulin

1997 • 142 citations

Passage of peptides across the blood-brain barrier: Pathophysiological perspectives

1996 • 119 citations

Epidermal growth factor and the nervous system

1991 • 118 citations

Penetration of neurotrophins and cytokines across the blood–brain/blood–spinal cord barrier

1999 • 94 citations

Epidermal Growth Factor Protects Neuronal CellsIn VivoandIn Vitroagainst Transient Forebrain Ischemia- and Free Radical-Induced Injuries

1998 • 85 citations

Interaction of Epidermal Growth Factor With the Hypothalamic-Pituitary-Adrenal Axis: Potential Physiologic Relevance*

1988 • 59 citations

Epidermal Growth Factor Prevents Oxygen‐triggered Apoptosis and Induces Sustained Signalling in Cultured Rat Cerebral Cortical Neurons

1995 • 52 citations

Localized delivery of proteins in the brain: can transport be customized?

1998 • 51 citations

Regional variation in transport of pancreatic polypeptide across the blood-brain barrier of mice

1995 • 47 citations

Cyanocobalamin, vitamin B12, depresses glutamate release through inhibition of voltage-dependent Ca2+ influx in rat cerebrocortical nerve terminals (synaptosomes)

2008 • 45 citations

Food intake suppression by growth factors and platelet peptides by direct action in the central nervous system

1988 • 44 citations

Epidermal growth factor acts as a corticotropin-releasing factor in chronically catheterized fetal lambs.

1987 • 42 citations

Modification of anoxic neuronal injury by human recombinant epidermal growth factor and its possible mechanism

1990 • 40 citations

Plasma concentrations and urinary excretion of mouse epidermal growth factor associated with the inhibition of food consumption and of wool growth in Merino wethers

1982 • 34 citations

Epidermal growth factor does not cross the blood-brain barrier

1985 • 21 citations