Epidermal Growth Factor: Structure, Expression, and Functions in the Central Nervous System

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

1985 • 1,063 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

1987 • 843 citations

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.

1987 • 814 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Transforming growth factor α

1988 • 707 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor

1984 • 666 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family

1989 • 586 citations

Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues

1985 • 568 citations

Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II

1990 • 529 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

Expression of epidermal growth factor receptors in human brain tumors.

1984 • 478 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor

1988 • 408 citations

Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization

1990 • 387 citations

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory Activity

1990 • 359 citations

Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies

1991 • 327 citations

Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor

1987 • 297 citations

Epidermal Growth Factor Immunoreactive Material in the Central Nervous System: Location and Development

1984 • 266 citations

Vaccinia virus encodes a polypeptide homologous to epidermal growth factor and transforming growth factor

1985 • 249 citations

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.

1990 • 241 citations

Epidermal Growth Factor

1972 • 214 citations

The ontogeny of epidermal growth factor receptors during mouse development

1984 • 213 citations

Epidermal growth factor binding and mitogenic activity on purified populations of cells from the central nervous system

1982 • 206 citations

Epidermal growth factor stimulates DNA-synthesis of astrocytes in primary cerebellar cultures

1981 • 197 citations

Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain

1988 • 189 citations

Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-alpha mRNA in mouse brain by a quantitative nuclease protection assay

1992 • 188 citations

Epidermal growth factor receptor immunoreactivity in rat brain. Development and cellular localization

1988 • 176 citations

EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary cell culture

1991 • 173 citations

Stage- and tissue-specific expression of the neu oncogene in rat development.

1987 • 163 citations

Localization of immunoreactive epidermal growth factor receptors in human nervous system.

1988 • 155 citations

Structure, expression and function of a schwannoma-derived growth factor

1990 • 153 citations

Density dependent proliferation of human glia cells stimulated by epidermal growth factor

1976 • 150 citations

Basic fibroblast growth factor and epidermal growth factor exert differential trophic effects on CNS neurons

1988 • 149 citations

Developmental Expression of Rat Transforming Growth Factor-α mRNA

1985 • 147 citations

Vaccinia virus-infected cells release a novel polypeptide functionally related to transforming and epidermal growth factors.

1985 • 146 citations

Epidermal growth factor and transforming growth factor .alpha. bind differently to the epidermal growth factor receptor

1989 • 130 citations

Developmental expression of rat transforming growth factor-alpha mRNA.

1985 • 114 citations

Expression and characterization of transforming growth factor alpha precursor protein in transfected mammalian cells.

1987 • 100 citations

Astrocyte Mitogen Inhibitor Related to Epidermal Growth Factor Receptor

1988 • 95 citations

Transforming growth factor-α in the mammalian brain

1989 • 94 citations

An insertional mutant of epidermal growth factor receptor allows dissection of diverse receptor functions.

1987 • 85 citations

Epidermal growth factor and basic fibroblast growth factor: effects on an overlapping population of neocortical neurons in vitro

1990 • 80 citations

Epidermal growth factor and bovine growth hormone stimulate differentiation and myelination of brain cell aggregates in culture

1985 • 79 citations

Epidermal growth factor (EGF) stimulation of cultured brain cells. I. Enhancement of the developmental increase in glial enzymatic activity

1983 • 77 citations

Structure and bioactivity of the amino-terminal fragment of pro-opiomelanocortin

1986 • 73 citations

Structural properties of a soluble bioactive precursor for transforming growth factor-alpha.

1988 • 65 citations

Transforming growth factor alpha, but not epidermal growth factor, promotes the survival of sensory neurons in vitro

1992 • 63 citations

Epidermal Growth Factor Immunoreactive Material in the Rat Brain

1989 • 56 citations

Localization of Cells Containing Transforming Growth Factor- α Precursor Immunoreactivity in the Basal Ganglia of the Adult Rat Brain

1990 • 53 citations

Effect of cholinergic deficit induced by ethylcholine aziridinium (AF64A) on noradrenergic and dopaminergic parameters in rat brain

1987 • 52 citations

Epidermal Growth Factor in Synaptosomal Fractions of Mouse Cerebral Cortex

1986 • 49 citations

Epidermal growth factor induces tyrosine hydroxylase in a clonal pheochromocytoma cell line, PC-G2.

1980 • 45 citations

The epidermal growth factor precursor isolated from murine kidney membranes. Chemical characterization and biological properties.

1990 • 41 citations

Nervous System Regeneration

1984 • 41 citations

Epidermal growth factor is not detectable in developing and adult rodent brain by a sensitive double-site enzyme immunoassay

1986 • 40 citations

Modification of anoxic neuronal injury by human recombinant epidermal growth factor and its possible mechanism

1990 • 40 citations

Epidermal growth factor receptor expression in demented and aged human brain

1990 • 36 citations

Visualization of growth factor receptor sites in rat forebrain

1988 • 36 citations

Epidermal growth factor inhibits the expression of myelin basic protein in oligodendrocytes

1989 • 32 citations

Homeotic gene products as growth factors

1985 • 26 citations

Modulation of beta‐adrenergic response in rat brain astrocytes by serum and hormones

1985 • 25 citations

Some transforming growth factor-alpha connections and their colocalization with enkephalin in the rat central nervous system

1987 • 22 citations

Is epidermal growth factor a modulator of nervous system function?

1983 • 9 citations

Neuromodulation by polypeptide growth factors: preliminary results on the distribution of epidermal growth factor receptors in adult brain.

1988 • 8 citations

Vaccinia Growth Factor: Newest Member of the Family of Growth Modulators Which Utilize the Membrane Receptor for EGF

1987 • 7 citations