The neurotrophins and their receptors

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

1992 • 960 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The changing scene of neurotrophic factors

1991 • 827 citations

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1991 • 819 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor

1990 • 720 citations

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

1990 • 702 citations

The nerve growth factor family of receptors

1992 • 649 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Primary structure and biological activity of a novel human neurotrophic factor

1990 • 553 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells

1993 • 525 citations

Ras C-terminal processing enzymes—New drug targets?

1991 • 461 citations

Nerve growth factor mediates signal transduction through trk homodimer receptors

1992 • 458 citations

Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor.

1992 • 458 citations

Gene Transfer and Molecular Cloning of the Human NGF Receptor

1986 • 447 citations

Alternative forms of rat TrkC with different functional capabilities

1993 • 374 citations

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

1990 • 342 citations

Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product

1992 • 336 citations

Expression and possible function of nerve growth factor receptors on Schwann cells

1988 • 304 citations

Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors

1991 • 296 citations

Trkl3 mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor

1991 • 294 citations

The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells

1993 • 290 citations

Expression of Functional Nerve Growth Factor Receptors After Gene Transfer

1989 • 235 citations

The fibroblast growth factor family.

1990 • 219 citations

Molecular characteristics of nerve growth factor receptors on PC12 cells.

1985 • 200 citations

Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors.

1984 • 197 citations

SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells.

1993 • 170 citations

The trk family of tyrosine protein kinase receptors

1991 • 170 citations

Nerve growth factor effects and receptors in cultured human neuroblastoma cell lines

1982 • 168 citations

Molecular investigations on the high-affinity nerve growth factor receptor

1991 • 154 citations

The beta-PDGF receptor induces neuronal differentiation of PC12 cells.

1992 • 145 citations

K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses.

1992 • 140 citations

Membrane Depolarization Induces p140 ^trk and NGF Responsiveness, but Not p75 ^LNGFR , in MAH Cells

1992 • 120 citations

Chimeric NGF-EGF Receptors Define Domains Responsible for Neuronal Differentiation

1991 • 116 citations

The internalization of nerve growth factor by high-affinity receptors on pheochromocytoma PC12 cells.

1987 • 98 citations

The neurite-promoting effect of fibroblast growth factor on PC12 cells

1983 • 88 citations

Role of protein tyrosine phosphorylation in the NGF response

1989 • 52 citations

Activation of Microtubule‐Associated Protein Kinase in PC12D Cells in Response to Both Fibroblast Growth Factor and Epidermal Growth Factor and Concomitant Stimulation of the Outgrowth of Neurites

1992 • 31 citations

Epidermal growth factor and transforming growth factor‐α can induce neuronal differentiation of rat pheochromocytoma PC 12 cells under particular culture conditions

1993 • 29 citations

Stimulation of Ig production and growth of human lymphoblastoid B-cell lines by nerve growth factor.

1991 • 24 citations

Tempus edax rerum

1991 • 4 citations