Peptides and the blood-brain barrier: Lipophilicity as a predictor of permeability

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

1971 • 1,671 citations

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1980 • 799 citations

Protein size and cerebrospinal fluid composition

1974 • 386 citations

Frontiers in Neuroendocrinology, 1973.

1973 • 302 citations

CNS effects of peripherally administered brain peptides

1979 • 278 citations

Entry of Opioid Peptides into the Central Nervous System

1980 • 247 citations

Methods for quantifying the transport of drugs across brain barrier systems

1981 • 214 citations

A simple kit for the preparation of 99mTc-labeled red blood cells.

1976 • 152 citations

Carrier-Mediated Transport of Thyroid Hormones through the Rat Blood-Brain Barrier: Primary Role of Albumin-Bound Hormone*

1979 • 151 citations

Permeability of the blood-brain barrier to neuropeptides: The case for penetration

1985 • 124 citations

The satiety effect of cholecystokinin: A progress report

1981 • 119 citations

Distribution of 3H-α-MSH in rat brain

1976 • 110 citations

ALUMINIUM INCREASES PERMEABILITY OF THE BLOOD-BRAIN BARRIER TO LABELLED DSIP AND β-ENDORPHIN: POSSIBLE IMPLICATIONS FOR SENILE AND DIALYSIS DEMENTIA

1983 • 110 citations

beta-Endorphin: stability, clearance behavior, and entry into the central nervous system after intravenous injection of the tritiated peptide in rats and rabbits.

1980 • 98 citations

Neurobiology of Cerebrospinal Fluid 2.

1983 • 97 citations

Cholecystokinin acts on the hypothalamic “noradrenergic system” involved in feeding

1980 • 89 citations

A brain-to-blood carrier-mediated transport system for small, N-Tyrosinated peptides

1984 • 77 citations

Brain and Cerebrospinal Fluid Permeability to Intravenous Thyroid Hormones*

1974 • 76 citations

Study of protein characteristics that influence entry into the cerebrospinal fluid of normal mice and mice with encephalitis.

1982 • 69 citations

Aluminum alters the permeability of the blood-brain barrier to some non-peptides

1985 • 61 citations

Evidence that [125I]N-Tyr-delta sleep-inducing peptide crosses the blood-brain barrier by a non-competitive mechanism

1984 • 61 citations

Exchange of Albumin Between Plasma and Cerebrospinal Fluid

1953 • 59 citations

Albumin Exchange Between Plasma and Cerebrospinal Fluid

1967 • 58 citations

Studies on the Transfer of Steroid Hormones Across Blood-Cerebrospinal Fluid Barrier in the Rhesus Monkey. II.

1977 • 55 citations

Radioimmunoassay of DSIP-like material in human blood: Possible protein binding

1981 • 55 citations

An enzymatically stable peptide with activity in the central nervous system: Its penetration through the blood-CSF barrier

1977 • 55 citations

Pharmaceutical Sciences—1964

1965 • 53 citations

Permeability of blood-brain barrier to DSIP peptides

1981 • 52 citations

Delta sleep-inducing peptide crosses the blood-brain-barrier in dogs: Some correlations with protein binding

1982 • 51 citations

Differential penetration of DSIP peptides into rat brain

1982 • 42 citations

Low permeation of systemically administered human ß-endorphin into rabbit brain measured by radioimmunoassays differentiating human and rabbit ß-endorphin

1980 • 37 citations

Does DDAVP (1-Desamino-8-<i>D</i>-Arginine-Vasopressin) Cross the Blood-CSF Barrier?

1983 • 34 citations

Studies on the Transfer of Steroid Hormones Across the Blood-Cerebrospinal Fluid Barrier in the Rhesus Monkey

1976 • 32 citations

Delta sleep-inducing peptide (DSIP)-like material is absorbed by the gastrointestinal tract of the neonatal rat

1983 • 30 citations

The aluminum-induced increase in blood-brain barrier permeability to delta-sleep-inducing peptide occurs throughout the brain and is independent of phosphorus and acetylcholinesterase levels

1985 • 29 citations

Evidence for peptide aggregation

1984 • 25 citations

The accumulation of (3H) enkephalinamide (2-D-alanine-5-methioninamide) in rat brain tissues

1978 • 21 citations

Enkephalin-binding systems in human plasma

1983 • 20 citations

Ultracentrifugation evidence for a somatostatin-binding protein in serum

1979 • 14 citations

Interpretation of Drug Levels: Relevance of Plasma Protein Binding

1980 • 14 citations

Impermeability of the Rat Blood-Brain Barrier to Exogenously Administered Gonadotropin-Releasing Hormone

1983 • 14 citations

On Plasma/Serum Interferences on Radioimmunoassay of Regulatory Peptides

1984 • 12 citations

Choroid-Plexus Transport of Enkephalins and Other Neuropeptides

1983 • 11 citations

THE INFLUENCE OF SALTS AND NON-ELECTROLYTES UPON THE HEART

1908 • 7 citations