Fibrolast growth factors in the nervous system

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

Structural and Functional Diversity in the FGf Receptor Multigene Family

1992 • 1,262 citations

Nucleotide Sequence of a Bovine Clone Encoding the Angiogenic Protein, Basic Fibroblast Growth Factor

1986 • 1,032 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation.

1985 • 941 citations

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

1984 • 937 citations

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy

1990 • 840 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

High and low affinity binding sites for basic fibroblast growth factor on cultured cells: Absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells

1987 • 653 citations

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

1990 • 635 citations

Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction

1992 • 625 citations

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

1988 • 599 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation.

1983 • 564 citations

Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

1993 • 542 citations

FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.

1991 • 541 citations

Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

1989 • 527 citations

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

1987 • 525 citations

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma

1991 • 523 citations

An Essential Heparin-Binding Domain in the Fibroblast Growth Factor Receptor Kinase

1993 • 520 citations

Mechanism of Protein Translocation Across the Endoplasmic Reticulum Membrane

1986 • 509 citations

Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.

1987 • 495 citations

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

1989 • 492 citations

Unique Expression Pattern of the FGF Receptor 3 Gene during Mouse Organogenesis

1993 • 456 citations

Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor.

1993 • 449 citations

Expression cDNA Cloning of the KGF Receptor by Creation of a Transforming Autocrine Loop

1991 • 427 citations

Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.

1992 • 404 citations

Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization

1990 • 387 citations

Basic FGF in adult rat brain: cellular distribution and response to entorhinal lesion and fimbria-fornix transection

1992 • 367 citations

Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro

1987 • 336 citations

Nuclear and cytoplasmic localization of different basic fibroblast growth factor species

1990 • 332 citations

Platelet-derived growth factors and fibroblast growth factors are mitogens for rat Schwann cells.

1990 • 316 citations

The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci 1992 Mar;12(3):685]

1991 • 310 citations

Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.

1989 • 294 citations

cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.

1987 • 293 citations

Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblasts

1986 • 285 citations

The brain fibroblast growth factor (FGF) is localized in neurons

1986 • 276 citations

Ligand-affinity cloning and structure of a cell surface heparan sulfate proteoglycan that binds basic fibroblast growth factor.

1990 • 274 citations

A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor.

1992 • 272 citations

Purification and characterization of acidic fibroblast growth factor from bovine brain.

1984 • 267 citations

Expression of FGF receptor gene in rat development

1991 • 264 citations

K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes.

1990 • 260 citations

Fibroblast growth factor stimulates the proliferation and differentiation of neural precursor cells in vitro

1990 • 257 citations

Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: A sequence of events in sympathetic development

1988 • 252 citations

Purification of two astroglial growth factors from bovine brain

1985 • 235 citations

Basic Fibroblast Growth Factor (FGF) in the Central Nervous System: Identification of Specific Loci of Basic FGF Expression in the Rat Brain

1989 • 233 citations

Cooperation between PDGF and FGF converts slowly dividing O-2Aadult progenitor cells to rapidly dividing cells with characteristics of O-2Aperinatal progenitor cells.

1992 • 230 citations

Fibroblast growth factor is a mitogen for oligodendrocytes in vitro

1985 • 227 citations

Isolation and partial molecular characterization of pituitary fibroblast growth factor.

1984 • 225 citations

Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system

1990 • 212 citations

Multiple influences of a heparin-binding growth factor on neuronal development.

1987 • 212 citations

Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines

1992 • 207 citations

Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).

1989 • 203 citations

Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons

1993 • 198 citations

Nuclear and cytoplasmic localization of basic fibroblast growth factor in astrocytes and CA2 hippocampal neurons

1992 • 192 citations

Ligand-induced transphosphorylation between different FGF receptors.

1991 • 189 citations

Prominent expression of acidic fibroblast growth factor in motor and sensory neurons

1991 • 189 citations

Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors.

1990 • 187 citations

Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.

1988 • 181 citations

Acidic and basic fibroblast growth factors in the nervous system: distribution and differential alteration of levels after injury of central versus peripheral nerve

1991 • 161 citations

Peptide growth factors protect against ischemia in culture by preventing nitric oxide toxicity

1993 • 160 citations

Acidic Fibroblast Growth Factor Enhances Peripheral Nerve Regeneration in Vivo

1989 • 157 citations

Neurotrophic effects of basic and acidic fibroblast growth factors are not mediated through glial cells

1988 • 156 citations

Evidence that fibroblast growth factor 5 is a major muscle-derived survival factor for cultured spinal motoneurons

1993 • 132 citations

Related fibroblast growth factor receptor genes exist in the human genome.

1990 • 131 citations

Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors.

1988 • 130 citations

Protective effects of basic fibroblast growth factor against hippocampal neuronal damage following cerebral ischemia in the gerbil

1993 • 128 citations

Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival

1991 • 127 citations

Differential expression of two members of FGF receptor gene family, FGFR-1 and FGFR-2 mRNA, in the adult rat central nervous system

1993 • 124 citations

Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways

1993 • 117 citations

Developmental and regional expression of basic fibroblast growth factor mRNA in the rat central nervous system

1990 • 115 citations

Purification and characterization of a trophic factor for embryonic peripheral neurons: Comparison with fibroblast growth factors

1990 • 111 citations

Heparan sulphate in the binding and activation of basic fibroblast growth factor

1992 • 107 citations

Altered Acidic and Basic Fibroblast Growth Factor Expression Following Spinal Cord Injury

1993 • 106 citations

Localization of bFGF and FGF‐receptor in the developing nervous system of the embryonic and newborn rat

1993 • 106 citations

Binding of heparin to basic fibroblast growth factor induces a conformational change

1992 • 103 citations

Multiple mRNAs code for proteins related to the BEK fibroblast growth factor receptor.

1991 • 101 citations

Fibroblast growth factor receptor‐bearing neurons in the CNS: Identification by receptor‐mediated retrograde transport

1991 • 100 citations

Basic fibroblast growth factor in the hypoglossal system: Specific retrograde transport, trophic, and lesion‐related responses

1992 • 97 citations

Fibroblast growth factor (FGF) levels in the developing rat brain

1990 • 91 citations

Temporal, differential and regional expression of mRNA for basic fibroblast growth factor in the developing and adult rat brain

1991 • 90 citations

A naturally occurring secreted form of fibroblast growth factor (FGF) receptor 1 binds basic FGF in preference over acidic FGF.

1992 • 88 citations

Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development

1991 • 86 citations

Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system.

1990 • 86 citations

Regulation of Astrocytic Tenascin by Basic Fibroblast Growth Factor

1993 • 81 citations

Developmental expression of the basic fibroblast growth factor gene in rat brain

1991 • 81 citations

Localization of acidic fibroblast growth factor in specific subcortical neuronal populations

1992 • 77 citations

Basic fibroblast growth factor stimulates survival of nonneuronal cells developing from trunk neural crest

1989 • 75 citations

Cytokine Regulation of Nerve Growth Factor‐Mediated Cholinergic Neurotrophic Activity Synthesized by Astrocytes and Fibroblasts

1992 • 68 citations

Stimulation of neuron survival by basic FGF and CNTF is a direct effect and not mediated by non-neuronal cells: evidence from single cell cultures

1992 • 66 citations

Mice expressing a bovine basic fibroblast growth factor transgene in the brain show increased resistance to hypoxemic-ischemic cerebral damage.

1993 • 66 citations

Acidic fibroblast growth factor prevents death of hippocampal CA1 pyramidal cells following ischemia

1992 • 55 citations

Flg-2, a new member of the family of fibroblast growth factor receptors.

1991 • 54 citations

Cloning of a major heparan sulfate proteoglycan from brain and identification as the rat form of glypican

1992 • 53 citations

Release of cell surface‐associated basic fibroblast growth factor by glycosylphosphatidylinositol‐specific phospholipase C

1992 • 50 citations

Heparan sulphate: Functional role as a modulator of fibroblast growth factor activity

1993 • 47 citations

Processing and Subcellular Distribution of the Schwann Cell Lipid-Anchored Heparan Sulfate Proteoglycan and Identification as Glypican

1993 • 45 citations

Distribution of fibroblast growth factor 5 mRNA in the rat brain: an in situ hybridization study

1993 • 42 citations

Differential Localization and Possible Functions of aFGF and bFGF in the Central and Peripheral Nervous Systems^a

1991 • 35 citations

Acidic Fibroblast Growth Factor Infusion Reduces Ischemic CA1 Hippocampal Damage in the Gerbil

1993 • 21 citations

Differential expression of acidic and basic FGF in the rat substantia nigra during development

1992 • 20 citations

Characterization of the FGFR‐3 Gene and Its Gene Product

1991 • 17 citations