Self‐Ignorance in the Peripheral T‐Cell Pool

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells.

1982 • 807 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept

1983 • 524 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

1983 • 441 citations

Effect of neonatal thymectomy on the immunological responsiveness of the mouse

1962 • 375 citations

Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice

1983 • 367 citations

Antigen Presentation Pathways to Class I and Class II MHC‐Restricted T Lymphocytes

1987 • 322 citations

Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway.

1991 • 298 citations

The CD2-LFA-3 and LFA-1-ICAM pathways: relevance to T-cell recognition

1989 • 269 citations

Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

1988 • 266 citations

Genetic susceptibility to post-thymectomy autoimmune diseases in mice

1981 • 265 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

Peripheral tolerance to an islet cell‐specific hemagglutinin transgene affects both CD4⁺ and CD8⁺ T cells

1992 • 217 citations

The Origin and Mechanism of the Allograft Reaction

1977 • 217 citations

A fail-safe mechanism for maintaining self-tolerance.

1992 • 213 citations

Function and Specificity of T Cell Subsets in the Mouse

1987 • 208 citations

Subsets of CD4⁺ T Cells and their Roles in the Induction and Prevention of Autoimmunity

1991 • 174 citations

The induction of skin graft tolerance in major histocompatibility complex‐mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti‐CD4 and anti‐CD8 antibodies

1990 • 157 citations

Neonatal Thymectomy Results in a Repertoire Enriched in T Cells Deleted in Adult Thymus

1989 • 146 citations

Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

1988 • 146 citations

Properties of purified T cell subsets. I. In vitro responses to class I vs. class II H-2 alloantigens.

1985 • 137 citations

The dosage requirements for immunological paralysis by soluble proteins.

1968 • 137 citations

Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen

1992 • 128 citations

Tolerance induction by thymic medullary epithelium.

1992 • 121 citations

T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions. A hypothesis

1989 • 121 citations

Expression in transgenic mice of class I histocompatibility antigens controlled by the metallothionein promoter.

1989 • 104 citations

Failure of clonal deletion in neonatally thymectomized mice: tolerance is preserved through clonal anergy.

1990 • 102 citations

Autoimmune oophoritis in thymectomized mice: T cell requirement in adoptive cell transfer.

1980 • 95 citations

The role of interleukin 2 in autoimmunity

1989 • 89 citations

Interleukin 2 abrogates the nonresponsive state of T cells expressing a forbidden T cell receptor repertoire and induces autoimmune disease in neonatally thymectomized mice.

1991 • 81 citations

Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin‐2 in islet β cells

1992 • 71 citations

Monoclonal antibodies against an H-2Kb-specific cytotoxic T cell clone detect several clone-specific molecules.

1986 • 61 citations

A Transgenic Approach to the Study of Peripheral T‐Cell Tolerance

1991 • 54 citations

Extrathymic Acquisition of Tolerance by T Lymphocytes

1989 • 38 citations

A nondeletional mechanism of peripheral tolerance in T-cell receptor transgenic mice.

1991 • 34 citations

The Florey Lecture, 1986 - The regulatory biology of antibody formation

1986 • 16 citations