New Thrombopoietic Growth Factors

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

1994 • 987 citations

Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial

2008 • 837 citations

Eltrombopag for the Treatment of Chronic Idiopathic Thrombocytopenic Purpura

2007 • 757 citations

Thrombocytopenia caused by the development of antibodies to thrombopoietin

2001 • 670 citations

Thrombokinetics in man

1969 • 658 citations

Erythropoietin Receptor Activation by a Ligand-Induced Conformation Change

1999 • 624 citations

Crystallographic Evidence for Preformed Dimers of Erythropoietin Receptor Before Ligand Activation

1999 • 597 citations

Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP

2003 • 526 citations

AMG 531, a Thrombopoiesis-Stimulating Protein, for Chronic ITP

2006 • 515 citations

Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin.

1996 • 445 citations

Eltrombopag for Thrombocytopenia in Patients with Cirrhosis Associated with Hepatitis C

2007 • 445 citations

The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production.

1994 • 443 citations

Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP

2008 • 429 citations

Peptide Agonist of the Thrombopoietin Receptor as Potent as the Natural Cytokine

1997 • 400 citations

Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance.

1987 • 395 citations

Recombinant human thrombopoietin: basic biology and evaluation of clinical studies

2002 • 365 citations

Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets

1996 • 348 citations

c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

2001 • 342 citations

Thrombopoietin

1998 • 313 citations

Bone marrow fibrosis: pathophysiology and clinical significance of increased bone marrow stromal fibres

2007 • 298 citations

Effects of Polyethylene Glycol–Conjugated Recombinant Human Megakaryocyte Growth and Development Factor on Platelet Counts after Chemotherapy for Lung Cancer

1997 • 298 citations

Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand

2004 • 295 citations

New thrombopoietic growth factors

2007 • 294 citations

Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura

2003 • 292 citations

Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist

2007 • 285 citations

Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets

1996 • 269 citations

High Thrombopoietin Production by Hematopoietic Cells Induces a Fatal Myeloproliferative Syndrome in Mice

1997 • 259 citations

Purification and Characterization of Thrombopoietin1

1995 • 251 citations

Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor

2002 • 244 citations

Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer

1996 • 226 citations

Stimulation of Megakaryocyte and Platelet Production by a Single Dose of Recombinant Human Thrombopoietin in Patients with Cancer

1997 • 226 citations

A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation

1996 • 206 citations

Randomized, Blinded, Placebo-Controlled Phase I Trial of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor With Filgrastim After Dose-Intensive Chemotherapy in Patients With Advanced Cancer

1997 • 206 citations

Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist

2005 • 201 citations

AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl

2003 • 195 citations

Thrombopoietin induces rapid resolution of thrombocytopenia after orthotopic liver transplantation through increased platelet production

2000 • 188 citations

Demonstration and Some Properties of Human Thrombopoietin in Thrombocythaemic Sera

1958 • 187 citations

Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation.

1995 • 183 citations

Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice

1995 • 177 citations

Interaction of thrombopoietin with the platelet c‐mpl receptor in plasma: binding, internalization, stability and pharmacokinetics

1999 • 167 citations

Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver?

1997 • 165 citations

Recombinant Human Thrombopoietin Attenuates Carboplatin-Induced Severe Thrombocytopenia and the Need for Platelet Transfusions in Patients with Gynecologic Cancer

2000 • 164 citations

Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice

1995 • 162 citations

Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates

1996 • 159 citations

Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity.

1995 • 154 citations

Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates

1996 • 151 citations

Cytokine reference : a compendium of cytokines and other mediators of host defence

2001 • 148 citations

Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.

1994 • 147 citations

Human Platelets as a Model for the Binding and Degradation of Thrombopoietin

1997 • 142 citations

Human Platelets Display High-Affinity Receptors for Thrombopoietin

1997 • 137 citations

Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions

2004 • 134 citations

Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura

2002 • 134 citations

Hepatitis C virus‐related thrombocytopenia: clinical and laboratory characteristics compared with chronic immune thrombocytopenic purpura

2005 • 124 citations

A Randomized, Double-Blind, Placebo-Controlled Study With Pegylated Recombinant Human Megakaryocyte Growth and Development Factor (PEG-rHuMGDF) as an Adjunct to Chemotherapy for Adults With De Novo Acute Myeloid Leukemia

1999 • 120 citations

Primary Role of the Liver in Thrombopoietin Production Shown by Tissue-Specific Knockout

1998 • 117 citations

Hydrazinonaphthalene and Azonaphthalene Thrombopoietin Mimics Are Nonpeptidyl Promoters of Megakaryocytopoiesis

2001 • 117 citations

A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia

2000 • 117 citations

Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice

1996 • 112 citations

Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice

1995 • 99 citations

Prophylactic platelet transfusions from healthy apheresis platelet donors undergoing treatment with thrombopoietin

2001 • 92 citations

Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment

2004 • 91 citations

Thrombopoietin therapy increases platelet yields in healthy platelet donors

2001 • 91 citations

Adenovector-Mediated Expression of Human Thrombopoietin cDNA in Immune-Compromised Mice: Insights into the Pathophysiology of Osteomyelofibrosis

1998 • 89 citations

Recombinant Human Thrombopoietin in Combination With Granulocyte Colony-Stimulating Factor Enhances Mobilization of Peripheral Blood Progenitor Cells, Increases Peripheral Blood Platelet Concentration, and Accelerates Hematopoietic Recovery Following High-Dose Chemotherapy

1999 • 86 citations

A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis

2006 • 86 citations

Appearance of a megakaryocyte growth-promoting activity, megapoietin, during acute thrombocytopenia in the rabbit

1994 • 86 citations

Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 1. Discovery and Optimization of Salicylaldehyde Thiosemicarbazone Thrombopoietin Mimics

2002 • 85 citations

The role of transforming growth factor‐β in PEG‐rHuMGDF‐induced reversible myelofibrosis in rats

1997 • 83 citations

A phase I trial of recombinant human thrombopoietin in patients with delayed platelet recovery after hematopoietic stem cell transplantation

2000 • 82 citations

Deletion of the Extracellular Membrane-Distal Cytokine Receptor Homology Module of Mpl Results in Constitutive Cell Growth and Loss of Thrombopoietin Binding

1999 • 80 citations

The structure, biology and potential therapeutic applications of recombinant thrombopoietin

1994 • 77 citations

AKR‐501 (YM477) a novel orally‐active thrombopoietin receptor agonist

2008 • 71 citations

Safety and efficacy of transfusions of autologous cryopreserved platelets derived from recombinant human thrombopoietin to support chemotherapy-associated severe thrombocytopenia: a randomised cross-over study

2002 • 70 citations

Thrombopoietin Administered During Induction Chemotherapy to Patients With Acute Myeloid Leukemia Induces Transient Morphologic Changes That May Resemble Chronic Myeloproliferative Disorders

2002 • 70 citations

A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor

2004 • 68 citations

Thrombopoietin receptor expression in human cancer cell lines and primary tissues.

1995 • 67 citations

The role of metalloproteinases and adhesion molecules in interleukin-8-induced stem-cell mobilization

2000 • 67 citations

Importance of Predosing of Recombinant Human Thrombopoietin to Reduce Chemotherapy-Induced Early Thrombocytopenia

2003 • 63 citations

Enhancement of Platelet Recovery After Myelosuppressive Chemotherapy by Recombinant Human Megakaryocyte Growth and Development Factor in Patients With Advanced Cancer

2000 • 60 citations

AKR-501 (YM477) in combination with thrombopoietin enhances human megakaryocytopoiesis

2008 • 59 citations

Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 2. Rational Design of Naphtho[1,2-d]imidazole Thrombopoietin Mimics

2002 • 59 citations

Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy

2001 • 59 citations

Single and Multiple Oral Doses of AKR-501 (YM477) Increase the Platelet Count in Healthy Volunteers.

2006 • 53 citations

A rationally designed agonist antibody fragment that functionally mimics thrombopoietin

2006 • 53 citations

Phase 1 study of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in breast cancer patients after autologous peripheral blood progenitor cell (PBPC) transplantation

2000 • 51 citations

Immunogenicity of Thrombopoietin Mimetic Peptide GW395058 in BALB/c Mice and New Zealand White Rabbits: Evaluation of the Potential for Thrombopoietin Neutralizing Antibody Production in Man

1999 • 49 citations

Relative reactivity of platelets from thrombopoietin- and interleukin-6- treated dogs

1996 • 47 citations

Late breaking abstracts

2007 • 44 citations

Phase 1/2 Study of AMG 531 in Thrombocytopenic Patients (pts) with Low-Risk Myelodysplastic Syndrome (MDS): Update Including Extended Treatment.

2007 • 44 citations

The effect of massive liver resection on platelet kinetics in the rat.

1975 • 42 citations

Roe versus Reality — Abortion and Women's Health

2006 • 41 citations

The effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet recovery in breast cancer patients undergoing autologous bone marrow transplantation

2002 • 40 citations

New drugs for familiar therapeutic targets: thrombopoietin receptor agonists and immune thrombocytopenic purpura

2008 • 40 citations

Structure and transcription of the genomic locus encoding murine c-Mpl, a receptor for thrombopoietin.

1995 • 39 citations

New benzimidazoles as thrombopoietin receptor agonists

2006 • 39 citations

Oral Eltrombopag for the Long-Term Treatment of Patients with Chronic Idiopathic Thrombocytopenic Purpura: Results of a Phase III, Double- Blind, Placebo-Controlled Study (RAISE)

2008 • 36 citations

Biologic and structural differences of thrombopoietic growth factors

2000 • 36 citations

Species Specificity and Receptor Domain Interaction of a Small Molecule TPO Receptor Agonist.

2004 • 34 citations

Biological Activity and Selectivity for Tpo Receptor of the Orally Bioavailable, Small Molecule Tpo Receptor Agonist, SB-497115.

2004 • 34 citations

Discovery of SB-497115, a Small-Molecule Thrombopoietin (TPO) Receptor Agonist for the Treatment of Thrombocytopenia.

2004 • 31 citations

Long-Term Dosing of AMG 531 in Thrombocytopenic Patients with Immune Thrombocytopenic Purpura: 48-Week Update.

2006 • 31 citations

The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis

2008 • 29 citations

Analysis of Bleeding in Patients with Immune Thrombocytopenic Purpura (ITP): A Randomized, Double-Blind, Placebo-Controlled Trial of Eltrombopag, an Oral Platelet Growth Factor.

2006 • 27 citations

An Oral, Non-Petide, Small Molecule Thrombopoietin Receptor Agonist Increases Platelet Counts in Healthy Subjects.

2004 • 24 citations

Late breaking abstracts

2006 • 23 citations

Transcriptional regulation of bone marrow thrombopoietin by platelet proteins

2008 • 21 citations

The Efficacy of Recombinant Thrombopoietin in Murine and Nonhuman Primate Models for Radiation‐Induced Myelosuppression and Stem Cell Transplantation

1998 • 21 citations

Stimulation of Platelet Production in Healthy Volunteers by a Novel Pegylated Peptide-Based Thrombopoietin (TPO) Receptor Agonist.

2005 • 21 citations

Characterization of novel non-peptide thrombopoietin mimetics, their species specificity and the activation mechanism of the thrombopoietin receptor

2008 • 20 citations

Effect of Romiplostim in Patients (pts) with Low or Intermediate Risk Myelodysplastic Syndrome (MDS) Receiving Azacytidine

2008 • 20 citations

Safety and Efficacy of Long-Term Treatment with Oral Eltrombopag for Chronic Idiopathic Thrombocytopenic Purpura.

2008 • 19 citations

Long-Term Treatment with Romiplostim in Patients with Chronic Immune Thrombocytopenic Purpura (ITP): 3-Year Update from An Open-Label Extension Study

2008 • 16 citations

YM477, a Novel Orally-Active Thrombopoietin Receptor Agonist.

2005 • 16 citations

Single and Multiple Oral Doses of LGD-4665, a Small Molecule Thrombopoietin Receptor Agonist, Increase Platelet Counts in Healthy Male Subjects

2007 • 14 citations

The oncogene V-MPL, a putative truncated cytokine receptor which immortalizes hematopoietic progenitors.

1991 • 13 citations

Evaluating safety and efficacy of AMG 531 for the treatment of thrombocytopenic patients with myelodysplastic syndrome (MDS): Preliminary results of a phase 1/2 study

2007 • 12 citations

Effects of SB559457, a Novel Small Molecule Thrombopoietin Receptor (TpoR) Agonist, on Human Hematopoietic Cell Growth and Differentiation.

2004 • 11 citations

Platelets in thrombotic disorders: quantitative and qualitative platelet disorders predisposing to arterial thrombosis.

1998 • 11 citations

Domain Subclass Conversion Improved Activity of Anti-Mpl Agonist Antibodies in the Form of Whole IgG.

2006 • 11 citations

Discovery of novel non-peptide thrombopoietin mimetic compounds that induce megakaryocytopoiesis

2008 • 7 citations

Evaluation of Bone Marrow Reticulin Formation in Romiplostim-Treated Adult Patients with Chronic Immune Thrombocytopenic Purpura (ITP).

2008 • 5 citations

EVALUATING THE LONG-TERM EFFICACY OF ROMIPLOSTIM (AMG 531) IN PATIENTS WITH CHRONIC IMMUNE THROMBOCYTOPENIC PURPURA (ITP) DURING AN OPEN-LABEL EXTENSION STUDY

2008 • 4 citations

Long-Term Dosing of AMG 531 in Thrombocytopenic Patients with Immune Thrombocytopenic Purpura: 2-Year Update.

2007 • 3 citations

Municipal Hospital Patient Care

1970 • 2 citations