Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Cytokine signal transduction

1994 • 1,358 citations

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

1994 • 1,081 citations

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

1994 • 987 citations

The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF Receptor

1992 • 897 citations

Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule

1991 • 879 citations

Growth of factor-dependent hemopoietic precursor cell lines.

1980 • 793 citations

IL3-dependent mouse clones that express B-220 surface antigen, contain ig genes in germ-line configuration, and generate B lymphocytes in vivo

1985 • 718 citations

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.

1989 • 711 citations

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

1992 • 693 citations

c-Mpl ligand is a humoral regulator of megakaryocytopoiesis

1994 • 689 citations

Thrombocytopenia in c-mpl-deficient mice

1994 • 680 citations

Rational Design of Potent Antagonists to the Human Growth Hormone Receptor

1992 • 633 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.

1992 • 525 citations

A new cytokine receptor superfamily

1990 • 506 citations

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1989 • 432 citations

Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro

1995 • 416 citations

Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5

1993 • 404 citations

A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors

1990 • 404 citations

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis

1993 • 359 citations

Functional domains of the granulocyte colony-stimulating factor receptor.

1991 • 342 citations

Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.

1995 • 333 citations

Homodimerization and constitutive activation of the erythropoietin receptor.

1992 • 326 citations

Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity

1990 • 325 citations

The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets

1995 • 286 citations

Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.

1994 • 275 citations

Subunit promiscuity among hemopoietic growth factor receptors

1991 • 273 citations

Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.

1993 • 206 citations

Activation and inhibition of erythropoietin receptor function: role of receptor dimerization.

1994 • 201 citations

Purification and characterization of the receptor for murine granulocyte colony-stimulating factor.

1990 • 180 citations

Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.

1993 • 174 citations

A single amino acid substitution in the exoplasmic domain of the human growth hormone (GH) receptor confers familial GH resistance (Laron syndrome) with positive GH-binding activity by abolishing receptor homodimerization.

1994 • 155 citations

MPLV: A retrovirus complex inducing an acute myeloproliferative leukemic disorder in adult mice

1986 • 140 citations

Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth.

1993 • 134 citations

Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond

1994 • 102 citations

Expression of the c-mpl proto-oncogene in human hematologic malignancies

1993 • 100 citations

Mitogenic and binding properties of monoclonal antibodies to the prolactin receptor in Nb2 rat lymphoma cells. Selective enhancement by anti-mouse IgG.

1990 • 74 citations

Activation and Inhibition of Erythropoietin Receptor Function: Role of Receptor Dimerization

1994 • 53 citations

Expression of the extracellular domain of the rat liver prolactin receptor and its interaction with ovine prolactin.

1993 • 39 citations

Structure and transcription of the genomic locus encoding murine c-Mpl, a receptor for thrombopoietin.

1995 • 39 citations

Signaling by the cytoplasmic domain of hematopoietin receptors involves two distinguishable mechanisms in hepatic cells.

1994 • 39 citations

Myeloid progenitor cells transformed by the myeloproliferative leukemia virus proliferate and differentiate in vitro without the addition of growth factors.

1989 • 39 citations

Constitutive activation of a variant of the env-mpl oncogene product by disulfide-linked homodimerization

1995 • 18 citations