Interaction of thrombopoietin with the platelet c‐mpl receptor in plasma: binding, internalization, stability and pharmacokinetics

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

1994 • 987 citations

Thrombocytopenia in c-mpl-deficient mice

1994 • 680 citations

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.

1992 • 525 citations

Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin.

1996 • 445 citations

The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production.

1994 • 443 citations

The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit

1995 • 399 citations

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis

1993 • 359 citations

The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets

1995 • 286 citations

Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets

1996 • 269 citations

High Thrombopoietin Production by Hematopoietic Cells Induces a Fatal Myeloproliferative Syndrome in Mice

1997 • 259 citations

The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl

1995 • 235 citations

Anagrelide, a therapy for thrombocythemic states: Experience in 577 patients

1992 • 229 citations

[11] Radioiodination of proteins by the use of the chloramine-T method

1980 • 225 citations

Randomized, Blinded, Placebo-Controlled Phase I Trial of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor With Filgrastim After Dose-Intensive Chemotherapy in Patients With Advanced Cancer

1997 • 206 citations

Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates

1995 • 204 citations

Respiratory Virus Infections After Marrow Transplant: The Fred Hutchinson Cancer Research Center Experience

1997 • 203 citations

Megakaryocyte growth and development factor. Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia.

1995 • 192 citations

Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.

1993 • 174 citations

Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates

1996 • 159 citations

Human Platelets as a Model for the Binding and Degradation of Thrombopoietin

1997 • 142 citations

Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin

1995 • 141 citations

Human Platelets Display High-Affinity Receptors for Thrombopoietin

1997 • 137 citations

Thrombopoietin: the Primary Regulator of Megakaryocyte and Platelet Production

1995 • 114 citations

Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production

1996 • 111 citations

Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: distinct interactions with the ligands for c-kit and FLT3

1996 • 109 citations

Thrombopoietin and Its Receptor, c-mpl, Are Constitutively Expressed by Mouse Liver Endothelial Cells: Evidence of Thrombopoietin as a Growth Factor for Liver Endothelial Cells

1998 • 99 citations

Interferon-tau and interferon-alpha interact with the same receptors in bovine endometrium. Use of a readily iodinatable form of recombinant interferon-tau for binding studies.

1994 • 94 citations

Association of thrombocytopenia with the use of intra-aortic balloon pumps

1998 • 93 citations

Appearance of a megakaryocyte growth-promoting activity, megapoietin, during acute thrombocytopenia in the rabbit

1994 • 86 citations

[13] Radioiodination by use of the Bolton-Hunter and related reagents

1980 • 69 citations

Regulation of the Serum Concentration of Thrombopoietin in Thrombocytopenic NF-E2 Knockout Mice

1997 • 68 citations

Thrombopoietin receptor expression in human cancer cell lines and primary tissues.

1995 • 67 citations

Multilineage Hematopoietic Recovery by a Single Injection of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor in Myelosuppressed Mice

1998 • 67 citations

Metabolism of Thrombopoietin (TPO) In Vivo: Determination of the Binding Dynamics for TPO in Mice

1997 • 48 citations

Evidence that Stimulation of Megakaryocytopoiesis by Low Dose Vincristine Results from an Effect on Platelets

1977 • 39 citations

Thrombopoietin, the c-mpl ligand, is a major regulator of platelet production

1995 • 38 citations

Thrombin cleaves recombinant human thrombopoietin: One of the proteolytic events that generates truncated forms of thrombopoietin

1997 • 37 citations

Thrombopoietin levels after chemotherapy and in naturally occurring human diseases

1998 • 36 citations

Thrombopoietin: Biology and Clinical Applications

1996 • 35 citations

Activity of the ligand for c‐mpl, thrombopoietin, in early haemopoiesis

1996 • 33 citations

Thrombopoiesis and Thrombopoietins

1997 • 30 citations

Thrombopoietin: More than a lineage‐specific megakaryocyte growth factor

1997 • 30 citations

Thrombopoietin: Biology, clinical applications, role in the donor setting

1996 • 26 citations

Regulation of platelet production.

1957 • 25 citations

GpIIb/IIIa+ subpopulation of rat megakaryocyte progenitor cells exhibits high responsiveness to human thrombopoietin.

1996 • 21 citations

The Regulation of Platelet Production In Vivo

1997 • 15 citations

Amount of mpl on bone marrow haemopoietic precursor cells from healthy volunteers and patients with refractory anaemia

1997 • 14 citations

Thrombopoietin and its receptor, the proto-oncogene c-mpl

1995 • 9 citations

Effect of thrombopoietin (c-Mpl ligand) alone and in combination with other hematopoietic growth factors on human megakaryocytopoiesis in serum-free cultures.

1997 • 6 citations