A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis

NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cells

2002 • 1,392 citations

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

1994 • 1,081 citations

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

1994 • 987 citations

c-Mpl ligand is a humoral regulator of megakaryocytopoiesis

1994 • 689 citations

Thrombocytopenia caused by the development of antibodies to thrombopoietin

2001 • 670 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

Model for growth hormone receptor activation based on subunit rotation within a receptor dimer

2005 • 369 citations

Recombinant human thrombopoietin: basic biology and evaluation of clinical studies

2002 • 365 citations

Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin

2004 • 348 citations

Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival.

1991 • 309 citations

Cholinesterase as a Possible Marker for Early Cells of the Megakaryocytic Series

1973 • 297 citations

Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain

2001 • 266 citations

Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation: immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in in vivo cells from normal and leukemic patients

1982 • 209 citations

Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist

2005 • 201 citations

The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production

2002 • 183 citations

Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7

1993 • 175 citations

Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7

1993 • 155 citations

Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions

2004 • 134 citations

Hydrazinonaphthalene and Azonaphthalene Thrombopoietin Mimics Are Nonpeptidyl Promoters of Megakaryocytopoiesis

2001 • 117 citations

Establishment and characterization of the thrombopoietin-dependent megakaryocytic cell line, UT-7/TPO

1996 • 108 citations

Blood platelet activation evaluated by flow cytometry: optimised methods for clinical studies

2000 • 94 citations

Identification of an oncogenic form of the thrombopoietin receptor MPL using retrovirus-mediated gene transfer

1996 • 91 citations

Activating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signalling.

1995 • 84 citations

Differences in megakaryocyte expansion potential between CD34+ stem cells derived from cord blood, peripheral blood, and bone marrow from adults and children

2000 • 66 citations

Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 2. Rational Design of Naphtho[1,2-d]imidazole Thrombopoietin Mimics

2002 • 59 citations

Increased plasma levels of stromal-derived factor-1 (SDF-1/CXCL12) enhance human thrombopoiesis and mobilize human colony-forming cells (CFC) in NOD/SCID mice

2004 • 54 citations

A non‐peptide compound which can mimic the effect of thrombopoietin via c‐Mpl

1998 • 50 citations

Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities

2004 • 41 citations

Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production

2001 • 40 citations

Species Specificity and Receptor Domain Interaction of a Small Molecule TPO Receptor Agonist.

2004 • 34 citations

Xanthocillins as thrombopoietin mimetic small molecules

2005 • 32 citations

Identification of Functional Domains of the Human Thrombopoietin Receptor Required for Growth and Differentiation of Megakaryocytic Cells

1997 • 28 citations

An Oral, Non-Petide, Small Molecule Thrombopoietin Receptor Agonist Increases Platelet Counts in Healthy Subjects.

2004 • 24 citations

A preclinical xenotransplantation animal model to assess human hematopoietic stem cell engraftment

2004 • 15 citations

Immunocytochemical studies on co-localization of -granule membrane IIb 3 integrin and intragranular fibrinogen of human platelets and their cell-surface expression during the thrombin-induced release reaction

2003 • 4 citations

Deleted Work

1955 • 0 citations