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2002 • 1,324 citations

Group Sequential Methods with Applications to Clinical Trials

1999 • 1,177 citations

AMG 531, a Thrombopoiesis-Stimulating Protein, for Chronic ITP

2006 • 515 citations

Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction

1996 • 455 citations

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1987 • 395 citations

Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro

2003 • 383 citations

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2002 • 365 citations

Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist

2007 • 285 citations

Circulating thrombopoietin level in chronic immune thrombocytopenic purpura

1996 • 215 citations

Mechanisms of Response to Treatment in Autoimmune Thrombocytopenic Purpura

1989 • 214 citations

Prospective screening of 205 patients with ITP, including diagnosis, serological markers, and the relationship between platelet counts, endogenous thrombopoietin, and circulating antithrombopoietin antibodies

2004 • 191 citations

An open‐label, unit dose‐finding study of AMG 531, a novel thrombopoiesis‐stimulating peptibody, in patients with immune thrombocytopenic purpura

2006 • 151 citations

Intracranial Hemorrhage in Immune Thrombocytopenic Purpura: A Retrospective Analysis

2003 • 147 citations

Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production

1996 • 111 citations

Thrombopoietin: a pan-hematopoietic cytokine

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The Effect of Antiplatelet Autoantibodies on Megakaryocytopoiesis

2005 • 70 citations

SB 497115-GR, a Low Molecular Weight TPOR Agonist, Does Not Induce Platelet Activation or Enhance Agonist-Induced Platelet Aggregation in Vitro.

2004 • 34 citations

Pharmacology and Safety of SB-497115-GR, an Orally Active Small Molecular Weight TPO Receptor Agonist, in Chimpanzees, Rats and Dogs.

2004 • 24 citations

The potential role of thrombopoietin in idiopathic thrombocytopenic purpura

2002 • 21 citations

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2004 • 11 citations

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1994 • 3 citations

In vitro and in vivo biology of a small molecular weight Tpo receptor agonist, SB-497115

2005 • 3 citations