Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

1996 • 589 citations

Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin

1998 • 389 citations

Role of c-mpl in Early Hematopoiesis

1998 • 362 citations

Thrombopoietin

1998 • 313 citations

Effects of Polyethylene Glycol–Conjugated Recombinant Human Megakaryocyte Growth and Development Factor on Platelet Counts after Chemotherapy for Lung Cancer

1997 • 298 citations

Low levels of erythroid and myeloid progenitors in thrombopoietin-and c- mpl-deficient mice

1996 • 287 citations

Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer

1996 • 226 citations

Stimulation of Megakaryocyte and Platelet Production by a Single Dose of Recombinant Human Thrombopoietin in Patients with Cancer

1997 • 226 citations

Randomized, Blinded, Placebo-Controlled Phase I Trial of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor With Filgrastim After Dose-Intensive Chemotherapy in Patients With Advanced Cancer

1997 • 206 citations

Soluble stem cell factor in human serum

1993 • 151 citations

Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation

1996 • 142 citations

Immunogenicity of recombinant IL-2 modified by covalent attachment of polyethylene glycol.

1990 • 136 citations

Serum thrombopoietin levels in patients with aplastic anaemia

1996 • 116 citations

Induction of anti-recombinant human granulocyte-macrophage colony- stimulating factor (Escherichia coli-derived) antibodies and clinical effects in nonimmunocompromised patients

1994 • 102 citations

Multilineage mobilization of peripheral blood progenitor cells in humans following administration of PEG‐rHuMGDF

1997 • 68 citations

Enhanced Levels and Enhanced Clonogenic Capacity of Blood Progenitor Cells Following Administration of Stem Cell Factor Plus Granulocyte Colony-Stimulating Factor to Humans

1997 • 61 citations

Enhancement of Platelet Recovery After Myelosuppressive Chemotherapy by Recombinant Human Megakaryocyte Growth and Development Factor in Patients With Advanced Cancer

2000 • 60 citations

Naturally occurring and therapy-induced antibodies to human granulocyte colony-stimulating factor (G-CSF) in human serum

1997 • 44 citations

Mpl Ligand (MGDF) Alone and in Combination with Stem Cell Factor (SCF) Promotes Proliferation and Survival of Human Megakaryocyte, Erythroid and Granulocyte/Macrophage Progenitors

1997 • 43 citations

Chronic Thrombocytopenia Is Induced in Dogs by Development of Cross-Reacting Antibodies to the MpL Ligand

1997 • 26 citations

Pharmacokinetic Analysis of Pegylated Megakaryocyte Growth and Development Factor in Humans

2000 • 9 citations

Pilot study of escalating doses of carboplatin and cyclophosphamide in patients with advanced cancer

1992 • 2 citations

Dose Escalation Study of Carboplatin and Cyclophosphamide With Filgrastim Support

1998 • 2 citations

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