Potential role of MCP-1 in endothelial cell tight junction `opening': signaling via Rho and Rho kinase

Rho GTPases in cell biology

2002 • 4,662 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

1998 • 1,943 citations

Chemokines

1997 • 1,926 citations

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

1998 • 1,356 citations

The Molecular Biology of Leukocyte Chemoattractant Receptors

1994 • 1,224 citations

THE CELL BIOLOGY OF THE BLOOD-BRAIN BARRIER

1999 • 988 citations

Signalling to and from tight junctions

2003 • 863 citations

Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

1998 • 847 citations

Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression

2000 • 815 citations

Oxidant stress and endothelial cell dysfunction

2001 • 802 citations

Inflammatory mediators and modulation of blood-brain barrier permeability.

2000 • 769 citations

Rho family proteins: coordinating cell responses

2001 • 763 citations

Molecular physiology and pathophysiology of tight junctions in the blood–brain barrier

2001 • 742 citations

MOLECULAR ARCHITECTURE OF TIGHT JUNCTIONS

1998 • 718 citations

The chemokine system: redundancy for robust outputs

1999 • 716 citations

Chemokines as regulators of T cell differentiation

2001 • 710 citations

Possible Involvement of Phosphorylation of Occludin in Tight Junction Formation

1997 • 576 citations

Oxidative Stress-Induced Actin Reorganization Mediated by the p38 Mitogen-Activated Protein Kinase/Heat Shock Protein 27 Pathway in Vascular Endothelial Cells

1997 • 569 citations

Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo

1999 • 559 citations

Epithelial cytoskeletal framework and nuclear matrix-intermediate filament scaffold: three-dimensional organization and protein composition.

1984 • 545 citations

Astrocyte expression of mRNA encoding cytokines IP‐10 and JE/MCP‐1 in experimental autoimmune encephalomyelitis

1993 • 496 citations

Regulation of vascular endothelial barrier function

1994 • 481 citations

Proteolytic Cascade Enzymes Increase in Focal Cerebral Ischemia in Rat

1996 • 408 citations

Activation of RhoA by Thrombin in Endothelial Hyperpermeability

2000 • 402 citations

Molecular structure and assembly of the tight junction

1998 • 399 citations

Regulation of TNF-α-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells

1998 • 390 citations

Expression of chemokine receptors by subsets of neurons in the central nervous system.

1997 • 384 citations

Actions of the chemotactic cytokines MCP‐1, MCP‐2, MCP‐3, RANTES, MIP‐1α and MIP‐1β on human monocytes

1995 • 349 citations

Early appearance of activated matrix metalloproteinase-9 and blood–brain barrier disruption in mice after focal cerebral ischemia and reperfusion

1999 • 340 citations

Rho/Rho-kinase mediated signaling in physiology and pathophysiology

2002 • 338 citations

Monocyte Chemoattractant Protein-1

1999 • 328 citations

Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain.

1996 • 311 citations

Rho-Kinase–Mediated Contraction of Isolated Stress Fibers

2001 • 309 citations

Regulation of Tight Junction Permeability and Occludin Phosphorylation by RhoA-p160ROCK-dependent and -independent Mechanisms

2001 • 300 citations

Calcium Modulation of Adherens and Tight Junction Function

2002 • 290 citations

Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin, and promotes albumin diffusion across cultured endothelial monolayers.

1986 • 289 citations

Regulation of Airway Tight Junctions by Proinflammatory Cytokines

2002 • 282 citations

Interferon-γ decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin

1999 • 281 citations

Chemokines and chemokine receptors in the CNS: a possible role in neuroinflammation and patterning

1999 • 275 citations

VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly

2001 • 274 citations

Expression of CCR2 by Endothelial Cells

1999 • 272 citations

Increased endothelial albumin permeability mediated by protein kinase C activation.

1990 • 271 citations

Transient and Prolonged Increase in Endothelial Permeability Induced by Histamine and Thrombin

1998 • 266 citations

IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways

2001 • 263 citations

Regulated assembly of tight junctions by protein kinase C.

1995 • 262 citations

Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression

2001 • 259 citations

ICAM-1 Signaling Pathways Associated with Rho Activation in Microvascular Brain Endothelial Cells

1998 • 252 citations

Molecular and cellular permeability control at the blood–brain barrier

2001 • 242 citations

Regulation of the Actin Cytoskeleton by Thrombin in Human Endothelial Cells: Role of Rho Proteins in Endothelial Barrier Function

1998 • 238 citations

Expression of CSF-1, c-fms, and MCP-1 in the central nervous system of rats with experimental allergic encephalomyelitis.

1993 • 218 citations

H₂O₂-mediated permeability: role of MAPK and occludin

2000 • 213 citations

Interleukin-1beta -induced changes in blood-brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: a magnetic resonance study.

2000 • 212 citations

Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forces.

1996 • 206 citations

Identification of a tight junction–associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability

2003 • 202 citations

Novel lymphocyte-specific CC chemokines and their receptors

1997 • 199 citations

Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins

1999 • 196 citations

Interleukin-1β-Induced Changes in Blood–Brain Barrier Permeability, Apparent Diffusion Coefficient, and Cerebral Blood Volume in the Rat Brain: A Magnetic Resonance Study

2000 • 190 citations

Tight Junction Proteins Form Large Complexes and Associate with the Cytoskeleton in an ATP Depletion Model for Reversible Junction Assembly

1997 • 189 citations

Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-γ

2001 • 181 citations

OVERRIDING THE BRAIN'S INTRINSIC RESISTANCE TO LEUKOCYTE RECRUITMENT WITH INTRAPARENCHYMAL INJECTIONS OF RECOMBINANT CHEMOKINES

1996 • 181 citations

Distribution, cellular localization and functional role of CCR2 chemokine receptors in adult rat brain

2002 • 175 citations

Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade

1993 • 174 citations

Interferon-γ and Interleukin-10 Reciprocally Regulate Endothelial Junction Integrity and Barrier Function

2001 • 168 citations

Regulation of endothelial cell gap formation and paracellular permeability.

1995 • 165 citations

Redistribution and Phosphorylation of Occludin During Opening and Resealing of Tight Junctions in Cultured Epithelial Cells

1999 • 164 citations

Protein kinase C phosphorylates caldesmon₇₇ and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

1992 • 163 citations

Vascular endothelial adhesion molecules and tissue inflammation.

1996 • 155 citations

Prevention of cerebral edema and infarct in cerebral reperfusion injury by an antibody to interleukin-8.

1997 • 154 citations

Chemokines and chemotaxis of leukocytes in infectious meningitis

1998 • 153 citations

Endothelial Permeability for Macromolecules

1997 • 139 citations

AIDS and the brain: is there a chemokine connection?

1999 • 135 citations

Intracellular signalling involved in modulating human endothelial barrier function*

2002 • 133 citations

Molecular mechanisms that control endothelial cell contacts

2000 • 129 citations

Rho and rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice

2002 • 124 citations

Deciphering Vascular Endothelial Cell Growth Factor/Vascular Permeability Factor Signaling to Vascular Permeability

2002 • 123 citations

Roles of Extracellular Signal‐regulated Kinase 1/2 and p38 Mitogen‐activated Protein Kinase in the Signal Transduction of Basic Fibroblast Growth Factor in Endothelial Cells during Angiogenesis

1999 • 122 citations

RhoA inactivation enhances endothelial barrier function

1999 • 120 citations

Expression of ?-chemokines and chemokine receptors in human fetal astrocyte and microglial co-cultures: Potential role of chemokines in the developing CNS

2001 • 120 citations

Small GTP-Binding Protein Rac Is an Essential Mediator of Vascular Endothelial Growth Factor-Induced Endothelial Fenestrations and Vascular Permeability

2003 • 119 citations

Cultured rat microglia express functional β-chemokine receptors

1999 • 117 citations

Paracrine angiogenic loop between head-and-neck squamous-cell carcinomas and macrophages

2001 • 114 citations

Interaction of PKC and NOS in signal transduction of microvascular hyperpermeability

1997 • 112 citations

Dependence of Epithelial Intercellular Junction Biogenesis on Thapsigargin-sensitive Intracellular Calcium Stores

1996 • 111 citations

Tight junction proteins1This review is dedicated to the memory of Thomas Kreis.1

1998 • 94 citations

The Chemokine Receptor CCR2 Mediates the Binding and Internalization of Monocyte Chemoattractant Protein-1 along Brain Microvessels

2001 • 90 citations

Atypical Protein Kinases Cλ and -ζ Associate with the GTP-Binding Protein Cdc42 and Mediate Stress Fiber Loss

2000 • 85 citations

Visualization of Chemokine Binding Sites on Human Brain Microvessels

1999 • 84 citations

The Role of p38 MAP Kinase in Hydrogen Peroxide Mediated Endothelial Solute Permeability

2001 • 77 citations

Increased expression of bioactive chemokines in human cerebromicrovascular endothelial cells and astrocytes subjected to simulated ischemia in vitro

1999 • 77 citations

Role of Protein Kinase Cζ in Ras-mediated Transcriptional Activation of Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression

2001 • 76 citations

Interaction of Protein Kinase C Isozymes with Rho GTPases

2001 • 74 citations

Expression of binding sites for ? chemokines on human astrocytes

1999 • 73 citations

Macrophages Stimulated with IFN-γ Activate NF-κB and Induce MCP-1 Gene Expression in Primary Human Endothelial Cells

2000 • 72 citations

Characterization of Binding Sites for Chemokines MCP‐1 and MIP‐1α on Human Brain Microvessels

2000 • 71 citations

Regulation of endothelial cell barrier function by calcium/calmodulin-dependent protein kinase II

2001 • 70 citations

Functional expression of CCR2 by human fetal astrocytes

2002 • 69 citations

Chemokines and cardiovascular diseases

2000 • 67 citations

Association of IL-8 and MCP-1 with the development of reexpansion pulmonary edema in rabbits

2001 • 61 citations

Interleukin-8 Increases Endothelial Permeability Independent of Neutrophils

1995 • 61 citations

Interactions between HIV-infected monocyte-derived macrophages and human brain microvascular endothelial cells result in increased expression of CC chemokines

2000 • 51 citations

Anin vitro model for endothelial permeability: Assessment of monolayer integrity

1995 • 51 citations

Regulation of yeast protein kinase C activity by interaction with the small GTPase Rho1p through its amino-terminal HR1 domain

2002 • 50 citations

Chemokines. Introduction and overview.

1999 • 49 citations

Extracellular signal-regulated protein kinase activation during reoxygenation is required to restore ischaemia-induced endothelial barrier failure

2002 • 49 citations

Functional expression of chemokine receptor 2 by normal human eosinophils

2001 • 46 citations

p38 MAPK and Ca²⁺contribute to hydrogen peroxide-induced increase of permeability in vascular endothelial cells but ERK does not

2001 • 45 citations

Protein kinase C β modulates thrombin-induced Ca2+ signaling and endothelial permeability increase

1998 • 43 citations

Phorbol esters increase MLC phosphorylation and actin remodeling in bovine lung endothelium without increased contraction

2003 • 42 citations

Introduction and Overview

1999 • 39 citations

Resting Distribution and Stimulated Translocation of Protein Kinase C Isoforms Alpha, Epsilon and Zeta in Response to Bradykinin and TNF in Human Endothelial Cells

1997 • 37 citations

Molecular decipherment of Rho effector pathways regulating tight-junction permeability

2000 • 36 citations

Vascular endothelial growth factor, a multifunctional polypeptide.

1996 • 32 citations

Platelet-activating factor modulates microvascular transport by stimulation of protein kinase C

1994 • 31 citations

Blood-CSF barrier integrity in multiple sclerosis

1996 • 29 citations

Signalling by Rho family proteins

1997 • 19 citations

in Human Monocytes

1980 • 18 citations