Tight junction proteins1This review is dedicated to the memory of Thomas Kreis.1

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

1963 • 3,559 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains

1997 • 1,371 citations

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

1998 • 1,356 citations

Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases

1995 • 994 citations

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

1994 • 949 citations

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

1998 • 923 citations

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.

1996 • 849 citations

Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments

1997 • 659 citations

Occludin is a functional component of the tight junction

1996 • 632 citations

A FINE STRUCTURAL ANALYSIS OF INTERCELLULAR JUNCTIONS IN THE MOUSE LIVER

1970 • 626 citations

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin

1998 • 592 citations

Possible Involvement of Phosphorylation of Occludin in Tight Junction Formation

1997 • 576 citations

The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy.

1993 • 567 citations

Structure, biochemistry, and assembly of epithelial tight junctions

1987 • 532 citations

Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions

1998 • 532 citations

A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier

1997 • 527 citations

Organization, Chemistry, and Assembly of the Cytoskeletal Apparatus of the Intestinal Brush Border

1985 • 525 citations

Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation

1997 • 524 citations

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

1991 • 520 citations

Cingulin, a new peripheral component of tight junctions

1988 • 505 citations

Afadin: A Novel Actin Filament–binding Protein with One PDZ Domain Localized at Cadherin-based Cell-to-Cell Adherens Junction

1997 • 473 citations

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

1993 • 467 citations

Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane.

1993 • 459 citations

Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivity.

1986 • 433 citations

Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.

1995 • 418 citations

Cell-to-cell adherens junction formation and actin filament organization: similarities and differences between non-polarized fibroblasts and polarized epithelial cells

1995 • 393 citations

Assembly of the tight junction: the role of diacylglycerol.

1993 • 381 citations

Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cells.

1988 • 366 citations

The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.

1996 • 353 citations

Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases

1998 • 349 citations

Intestinal absorptive cell tight junctions are linked to cytoskeleton

1987 • 343 citations

Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.

1995 • 337 citations

Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions.

1996 • 335 citations

Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues.

1996 • 329 citations

A membrane-cytoskeletal complex containing Na+,K+-ATPase, ankyrin, and fodrin in Madin-Darby canine kidney (MDCK) cells: implications for the biogenesis of epithelial cell polarity.

1989 • 319 citations

Evidence that tyrosine phosphorylation may increase tight junction permeability

1995 • 318 citations

The Ras Target AF-6 Interacts with ZO-1 and Serves as a Peripheral Component of Tight Junctions in Epithelial Cells

1997 • 315 citations

COOH Terminus of Occludin Is Required for Tight Junction Barrier Function in Early Xenopus Embryos

1997 • 301 citations

Protein–protein interactions: PDZ domain networks

1996 • 292 citations

Symplekin, a novel type of tight junction plaque protein.

1996 • 286 citations

Phosphorylation of occludin correlates with occludin localization and function at the tight junction

1997 • 286 citations

Assembly and sealing of tight junctions: Possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin

1991 • 280 citations

Mammalian occludin in epithelial cells: its expression and subcellular distribution.

1997 • 278 citations

Occludin confers adhesiveness when expressed in fibroblasts

1997 • 272 citations

Molecular Cloning and Functional Characterization of the Receptor for Clostridium perfringens Enterotoxin

1997 • 272 citations

Clostridium perfringens Enterotoxin Utilizes Two Structurally Related Membrane Proteins as Functional Receptors in Vivo

1997 • 270 citations

Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2.

1993 • 266 citations

Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation.

1993 • 260 citations

Twenty-first Bowditch lecture. The epithelial junction: bridge, gate, and fence.

1977 • 250 citations

Organization of the actin filament cytoskeleton in the intestinal brush border: a quantitative and qualitative immunoelectron microscope study.

1988 • 246 citations

Freeze-etch appearance of the tight junctions in the epithelium of small and large intestine of mice

1969 • 243 citations

A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites.

1991 • 234 citations

Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells

1994 • 232 citations

A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells

1994 • 228 citations

On tight-junction structure

1982 • 218 citations

Identification of AF-6 and Canoe as Putative Targets for Ras

1996 • 207 citations

The molecular organization of tight junctions.

1993 • 201 citations

Tight junctions

1998 • 197 citations

Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures

1996 • 193 citations

Biogenesis of tight junctions: The c-terminal domain of occludin mediates basolateral targeting

1998 • 193 citations

Tight Junction Proteins Form Large Complexes and Associate with the Cytoskeleton in an ATP Depletion Model for Reversible Junction Assembly

1997 • 189 citations

Two classes of tight junctions are revealed by ZO-1 isoforms

1993 • 189 citations

Tumor promoter-induced changes in the permeability of epithelial cell tight junctions

1981 • 185 citations

Expression and polarized targeting of a rab3 isoform in epithelial cells.

1994 • 179 citations

Occluding junctions in cultured epithelial monolayers

1981 • 173 citations

Detection of the tight junction-associated protein ZO-1 in astrocytes and other nonepithelial cell types

1992 • 162 citations

Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 α+ isoform

1997 • 160 citations

One hundred years of journal publication

1998 • 156 citations

Zonulae occludentes in junctional complex-enriched fractions from mouse liver: preliminary morphological and biochemical characterization.

1984 • 139 citations

Cingulin: Characterization and localization

1989 • 138 citations

Involvement of a Heterotrimeric G Protein α Subunit in Tight Junction Biogenesis

1996 • 136 citations

Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability

1996 • 134 citations

Phalloidin-induced cholestasis: a microfilament-mediated change in junctional complex permeability.

1980 • 131 citations

Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells

1995 • 128 citations

Identification of Isoforms of G Proteins and PKC that Colocalize with Tight Junctions

1996 • 127 citations

Isolation and Characterization of Transcripts Induced by Androgen Withdrawal and Apoptotic Cell Death in the Rat Ventral Prostate

1991 • 120 citations

Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance

1989 • 108 citations

The Movement of Solutes and Cells across Tight Junctionsa

1992 • 106 citations

Localization of 7H6 Tight Junction-Associated Antigen along the Cell Border of Vascular Endothelial Cells Correlates with Paracellular Barrier Function against Ions, Large Molecules, and Cancer Cells

1996 • 104 citations

Identification, Characterization, and Precise Mapping of a Human Gene Encoding a Novel Membrane-Spanning Protein from the 22q11 Region Deleted in Velo–Cardio–Facial Syndrome

1997 • 103 citations

Relationship of serine/threonine phosphorylation/dephosphorylation signaling to glucocorticoid regulation of tight junction permeability and ZO-1 distribution in nontransformed mammary epithelial cells.

1994 • 102 citations

The SH3 domain of the tight junction protein ZO‐1 binds to a serine protein kinase that phosphorylates a region C‐terminal to this domain

1996 • 102 citations

Participation of plasma membrane proteins in the formation of tight junction by cultured epithelial cells

1983 • 102 citations

The Tight Junction Protein ZO-2 Contains Three PDZ (PSD-95Discs-LargeZO-1) Domains and an Alternatively Spliced Region

1996 • 99 citations

The role of phosphorylation in development of tight junctions in cultured renal epithelial (MDCK) cells

1991 • 90 citations

Occludin dephosphorylation in early development of Xenopus laevis

1997 • 89 citations

Epithelial cell polarity in early Xenopus development

1995 • 81 citations

Cytoskeletal involvement in the modulation of cell-cell junctions by the protein kinase inhibitor H-7

1994 • 79 citations

Phosphorylation of the tight junction protein cingulin and the effects of protein kinase inhibitors and activators in MDCK epithelial cells

1995 • 68 citations

Localization of the 7H6 Antigen at Tight Junctions Correlates with the Paracellular Barrier Function of MDCK Cells

1994 • 56 citations

Formation of Functional Tight Junctions inXenopusEmbryos

1998 • 56 citations

Analysis of the distribution and phosphorylation state of ZO-1 in MDCK and nonepithelial cells

1994 • 53 citations

Effects of Tyrosine Phosphorylation on Tight Junctions in Temperature-Sensitive v-src-transfected MDCK Cells.

1995 • 53 citations

Cingulin, a specific protein component of tight junctions, is expressed in normal and neoplastic human epithelial tissues.

1991 • 52 citations

Different effects of protein kinase inhibitors on the localization of junctional proteins at cell-cell contact sites

1994 • 51 citations

Regulation of the MDCK Cell Tight Junction

1998 • 41 citations

Sequential Decrease in Tight Junctions as Revealed by 7H6 Tight Junction‐associated Protein during Rat Hepatocarcinogenesis

1994 • 34 citations

A protein associated with the mouse and rat hepatocyte junctional complex

1989 • 26 citations

Intercellular junctions in the Xenopus embryo prior to gastrulation

1976 • 26 citations

Brain capillary endothelial cells express MBEC1, a protein that is related to the Clostridium perfringens enterotoxin receptors.

1998 • 26 citations

Localization of a novel 210 kDa protein in Xenopus tight junctions

1997 • 21 citations