Molecular mechanisms that control endothelial cell contacts

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

1963 • 3,559 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

Traffic Signals on Endothelium for Lymphocyte Recirculation and Leukocyte Emigration

1995 • 1,525 citations

Morphogenetic roles of classic cadherins

1995 • 1,468 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

1998 • 1,356 citations

Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

1999 • 1,291 citations

Structural basis of cell-cell adhesion by cadherins

1995 • 1,173 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

1999 • 1,100 citations

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

1993 • 997 citations

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

1994 • 949 citations

PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily

1990 • 948 citations

Mechanisms That Regulate the Function of the Selectins and Their Ligands

1999 • 931 citations

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

1998 • 923 citations

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

1994 • 920 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

Nuclear localization of β-catenin by interaction with transcription factor LEF-1

1996 • 864 citations

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.

1996 • 849 citations

Tight junctions and the molecular basis for regulation of paracellular permeability

1995 • 825 citations

Cadherin-catenin complex: Protein interactions and their implications for cadherin function

1996 • 806 citations

Endothelial Claudin

1999 • 802 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

1990 • 753 citations

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.

1995 • 739 citations

β3-integrin–deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival

1999 • 731 citations

Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.

1991 • 719 citations

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

1994 • 712 citations

Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells

1998 • 695 citations

Structural basis of calcium-induced E-cadherin rigidification and dimerization

1996 • 688 citations

The biology of PECAM-1.

1997 • 669 citations

Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments

1997 • 659 citations

The role of αv integrins during angiogenesis: insights into potential mechanisms of action and clinical development

1999 • 651 citations

Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

1998 • 649 citations

A novel endothelial-specific membrane protein is a marker of cell-cell contacts.

1992 • 637 citations

Occludin as a possible determinant of tight junction permeability in endothelial cells

1997 • 626 citations

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin

1998 • 592 citations

Occludin and claudins in tight-junction strands: leading or supporting players?

1999 • 575 citations

The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin).

1995 • 573 citations

Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization

1992 • 562 citations

Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways

1997 • 543 citations

Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions

1998 • 532 citations

A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier

1997 • 527 citations

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

1991 • 520 citations

Cingulin, a new peripheral component of tight junctions

1988 • 505 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane

1999 • 469 citations

Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo

1993 • 468 citations

Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein

1994 • 452 citations

Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions

1999 • 430 citations

Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells.

1985 • 429 citations

Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP

1998 • 415 citations

EndoCAM: a novel endothelial cell-cell adhesion molecule.

1990 • 409 citations

A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation

1999 • 401 citations

CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion.

1992 • 383 citations

Protocadherins: a large family of cadherin-related molecules in central nervous system.

1993 • 371 citations

A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions.

1989 • 365 citations

Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

1991 • 363 citations

Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function

1997 • 357 citations

Cadherins and catenins in development

1996 • 344 citations

Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells.

1993 • 340 citations

A Role for the Cadherin Family of Cell Adhesion Molecules in Hippocampal Long-Term Potentiation

1998 • 336 citations

Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions.

1996 • 334 citations

Molecular cloning and expression of murine vascular endothelial- cadherin in early stage development of cardiovascular system

1996 • 325 citations

Vascular Permeability Factor/Vascular Endothelial Cell Growth Factor-mediated Permeability Occurs through Disorganization of Endothelial Junctional Proteins

1998 • 320 citations

The Ras Target AF-6 Interacts with ZO-1 and Serves as a Peripheral Component of Tight Junctions in Epithelial Cells

1997 • 315 citations

VE-cadherin antibody accelerates neutrophil recruitment in vivo

1997 • 314 citations

N-Cadherin Redistribution during Synaptogenesis in Hippocampal Neurons

1998 • 311 citations

Role of vascular endothelial-cadherin in vascular morphogenesis

1999 • 311 citations

Thrombin-Induced Increase in Endothelial Permeability Is Associated With Changes in Cell-to-Cell Junction Organization

1996 • 309 citations

Characterization of ZO-2 as a MAGUK Family Member Associated with Tight as well as Adherens Junctions with a Binding Affinity to Occludin and α Catenin

1999 • 302 citations

COOH Terminus of Occludin Is Required for Tight Junction Barrier Function in Early Xenopus Embryos

1997 • 301 citations

Differential Localization of VE- and N-Cadherins in Human Endothelial Cells: VE-Cadherin Competes with N-Cadherin for Junctional Localization

1998 • 297 citations

Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes.

1995 • 290 citations

Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin, and promotes albumin diffusion across cultured endothelial monolayers.

1986 • 289 citations

Symplekin, a novel type of tight junction plaque protein.

1996 • 286 citations

Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells

1997 • 285 citations

Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells.

1999 • 280 citations

Desmosomes and Hemidesmosomes: Constitutive Molecular Components

1990 • 280 citations

Immunoreceptor tyrosine-based inhibition motifs

1997 • 279 citations

Mammalian occludin in epithelial cells: its expression and subcellular distribution.

1997 • 278 citations

Molecular Cloning and Functional Characterization of the Receptor for Clostridium perfringens Enterotoxin

1997 • 272 citations

Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2.

1993 • 266 citations

Characterization of the interactions of α-catenin with α-actinin and β-catenin/plakoglobin

1997 • 260 citations

Regulation of Cadherin Function by Rho and Rac: Modulation by Junction Maturation and Cellular Context

1999 • 257 citations

Switched at birth: a new family for PECAM-1

1999 • 257 citations

Cell signalling: MAGUK magic

1996 • 248 citations

Identification of a putative cell adhesion domain of uvomorulin.

1985 • 246 citations

Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1.

1995 • 240 citations

Cutting Edge: Combined Treatment of TNF-α and IFN-γ Causes Redistribution of Junctional Adhesion Molecule in Human Endothelial Cells

1999 • 230 citations

Endothelial Cell E- and P-Selectin and Vascular Cell Adhesion Molecule-1 Function as Signaling Receptors

1998 • 230 citations

Targeted null-mutation in the vascular endothelial–cadherin gene impairs the organization of vascular-like structures in embryoid bodies

1997 • 221 citations

Catenin-dependent and -independent Functions of Vascular Endothelial Cadherin

1995 • 220 citations

Classical cadherins

1992 • 217 citations

VE-Cadherin Mediates Endothelial Cell Capillary Tube Formation in Fibrin and Collagen Gels1

1998 • 216 citations

The Protein-tyrosine Phosphatase SHP-2 Binds Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Forms a Distinct Signaling Complex during Platelet Aggregation

1997 • 215 citations

Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin.

1997 • 209 citations

An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane.

1996 • 198 citations

The Junction-associated Protein AF-6 Interacts and Clusters with Specific Eph Receptor Tyrosine Kinases at Specialized Sites of Cell–Cell Contact in the Brain

1999 • 195 citations

The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily

1997 • 192 citations

THE SITE OF LEUCOCYTE EMIGRATION DURING INFLAMMATION

1961 • 190 citations

Desmosomes and cytoskeletal architecture in epithelial differentiation: cell type-specific plaque components and intermediate filament anchorage.

1994 • 185 citations

Soluble Domain 1 of Platelet–Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo

1997 • 184 citations

Endothelial-dependent Mechanisms Regulate Leukocyte Transmigration: A Process Involving the Proteasome and Disruption of the Vascular Endothelial–Cadherin Complex at Endothelial Cell-to-Cell Junctions

1997 • 182 citations

Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta 2 integrin activation.

1996 • 180 citations

The Membrane-proximal Region of the E-Cadherin Cytoplasmic Domain Prevents Dimerization and Negatively Regulates Adhesion Activity

1998 • 173 citations

Ligation of platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) on monocytes and neutrophils increases binding capacity of leukocyte CR3 (CD11b/CD18).

1995 • 169 citations

IFN-gamma and TNF-alpha induce redistribution of PECAM-1 (CD31) on human endothelial cells.

1995 • 167 citations

Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro

1983 • 164 citations

Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cells.

1997 • 155 citations

Electron microscopy of leukocytic margination and emigration in acute inflammation in dog pancreas.

1961 • 147 citations

Homophilic adhesion by cadherins

1999 • 143 citations

A dominant mutant of occludin disrupts tight junction structure and function

1999 • 142 citations

Murine platelet endothelial cell adhesion molecule (PECAM‐1)/CD31 modulates β₂ integrins on lymphokine‐activated killer cells

1993 • 131 citations

VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: A pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions

1998 • 129 citations

Integrins in vascular development

1999 • 129 citations

Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells

1995 • 128 citations

Complexus adhaerentes, a new group of desmoplakin-containing junctions in endothelial cells: the syndesmos connecting retothelial cells of lymph nodes.

1993 • 127 citations

Endothelial transport of macromolecules: transcytosis and endocytosis. A look from cell biology.

1991 • 122 citations

Platelet endothelial cell adhesion molecule, PECAM‐1, modulates cell migration

1992 • 120 citations

Isolation and Characterization of Transcripts Induced by Androgen Withdrawal and Apoptotic Cell Death in the Rat Ventral Prostate

1991 • 120 citations

Leucocyte migration from small blood vessels stimulated with ultraviolet light: An electron‐microscope study

1961 • 119 citations

The Vascular Endothelial-Cadherin Promoter Directs Endothelial-Specific Expression in Transgenic Mice

1999 • 118 citations

Recruitment and Activation of SHP-1 Protein-tyrosine Phosphatase by Human Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)

1998 • 116 citations

Endothelial Cell VE-cadherin Functions as a Receptor for the β15–42 Sequence of Fibrin

1998 • 116 citations

Inhibition of platelet endothelial cell adhesion molecule-1 synthesis and leukocyte transmigration in endothelial cells by the combined action of TNF-alpha and IFN-gamma.

1996 • 112 citations

Complexus adhaerentes, a new group of desmoplakin-containing junctions in endothelial cells: II. Different types of lymphatic vessels

1994 • 107 citations

The Protein-tyrosine Phosphatase SHP-2 Associates with Tyrosine-phosphorylated Adhesion Molecule PECAM-1 (CD31)

1997 • 106 citations

Differential association of cytoplasmic signalling molecules SHP‐1, SHP‐2, SHIP and phospholipase C‐γ1 with PECAM‐1/CD31

1999 • 103 citations

Identification, Characterization, and Precise Mapping of a Human Gene Encoding a Novel Membrane-Spanning Protein from the 22q11 Region Deleted in Velo–Cardio–Facial Syndrome

1997 • 103 citations

Inhibitory receptors abound?

1997 • 103 citations

In Vitro Degradation of Endothelial Catenins by a Neutrophil Protease

1998 • 102 citations

Regulation of Mouse PECAM-1 Tyrosine Phosphorylation by the Src and Csk Families of Protein-tyrosine Kinases

1998 • 101 citations

Stimulated neutrophils induce myosin light chain phosphorylation and isometric tension in endothelial cells

1997 • 99 citations

A novel immunoglobulin superfamily junctional molecule expressed by antigen presenting cells, endothelial cells and platelets

1998 • 98 citations

Platelet/Endothelial Cell Adhesion Molecule-1 Serves as a Costimulatory Agonist Receptor That Modulates Integrin-Dependent Adhesion and Aggregation of Human Platelets

1998 • 94 citations

Protocadherins and diversity of the cadherin superfamily

1996 • 90 citations

Cadherin-5 redistribution at sites of TNF-α and IFN-γ-induced permeability in mesenteric venules

1999 • 86 citations

Identification of a Novel Cadherin (Vascular Endothelial Cadherin-2) Located at Intercellular Junctions in Endothelial Cells

1998 • 69 citations

Ultrastructural analysis of interleukin-1 beta-induced leukocyte recruitment to the rat retina.

1997 • 68 citations

Aggregation of the High Affinity IgE Receptor Results in the Tyrosine Phosphorylation of the Surface Adhesion Protein PECAM-1 (CD31)

1997 • 58 citations

Genomic Structure and Chromosomal Mapping of the Mouse VE-Cadherin Gene (Cdh5)

1996 • 51 citations

ACUTE INFLAMMATION. THE EARLIEST FINE STRUCTURAL CHANGES AT THE BLOOD-TISSUE BARRIER.

1963 • 49 citations

The Endothelial Junction

1988 • 46 citations

ELECTRON MICROSCOPIC OBSERVATIONS ON THE EMIGRATION OF LEUCOCYTES

1961 • 44 citations

Role of cadherins 5 and 13 in the aortic endothelial barrier

1997 • 42 citations

Gap junctions: more roles and new structural data

1999 • 32 citations

The Ultrastructure of Endothelial Gap-Formation and Leukocyte Emigration

2015 • 28 citations