Intracellular signalling involved in modulating human endothelial barrier function*

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness

2000 • 1,627 citations

Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

2000 • 1,219 citations

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

2001 • 1,035 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.

2000 • 900 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Microvascular Permeability

1999 • 769 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis

1999 • 752 citations

Vascular endothelial–cadherin is an important determinant of microvascular integrityinvivo

1999 • 659 citations

Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

1998 • 638 citations

Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo

1999 • 559 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation.

1995 • 451 citations

Activation of RhoA by Thrombin in Endothelial Hyperpermeability

2000 • 402 citations

Cofilin Phosphorylation and Actin Cytoskeletal Dynamics Regulated by Rho- and Cdc42-Activated Lim-Kinase 2

1999 • 384 citations

Thrombin Inactivates Myosin Light Chain Phosphatase via Rho and Its Target Rho Kinase in Human Endothelial Cells

1998 • 348 citations

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

1999 • 312 citations

Rho-Kinase–Mediated Contraction of Isolated Stress Fibers

2001 • 309 citations

Thrombin-Induced Increase in Endothelial Permeability Is Associated With Changes in Cell-to-Cell Junction Organization

1996 • 309 citations

Phosphorylation of Adducin by Rho-Kinase Plays a Crucial Role in Cell Motility

1999 • 300 citations

Regulation of Tight Junction Permeability and Occludin Phosphorylation by RhoA-p160ROCK-dependent and -independent Mechanisms

2001 • 300 citations

Increased endothelial albumin permeability mediated by protein kinase C activation.

1990 • 271 citations

Cofilin Phosphorylation by Protein Kinase Testicular Protein Kinase 1 and Its Role in Integrin-mediated Actin Reorganization and Focal Adhesion Formation

2001 • 267 citations

Transient and Prolonged Increase in Endothelial Permeability Induced by Histamine and Thrombin

1998 • 266 citations

Protein Kinase C-α Signals Rho-Guanine Nucleotide Dissociation Inhibitor Phosphorylation and Rho Activation and Regulates the Endothelial Cell Barrier Function

2001 • 253 citations

Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties

1989 • 251 citations

Regulation of microvascular permeability by vascular endothelial growth factors*

2002 • 250 citations

Rho as a Mediator of G Protein-Coupled Receptor Signaling

1999 • 244 citations

Simvastatin Inhibits Leukocyte–Endothelial Cell Interactions and Protects Against Inflammatory Processes in Normocholesterolemic Rats

1999 • 234 citations

Regulation of Cytosolic Guanylyl Cyclase by Nitric Oxide: The NO-Cyclic GMP Signal Transduction System

1994 • 232 citations

Histamine Induces Tyrosine Phosphorylation of Endothelial Cell-to-Cell Adherens Junctions

1999 • 229 citations

SHP2 Association with VE-Cadherin Complexes in Human Endothelial Cells Is Regulated by Thrombin

2000 • 212 citations

Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forces.

1996 • 206 citations

cGMP and Nitric Oxide Modulate Thrombin-Induced Endothelial Permeability

1995 • 201 citations

Simvastatin Exerts Both Anti-inflammatory and Cardioprotective Effects in Apolipoprotein E–Deficient Mice

2001 • 200 citations

Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK).

1998 • 199 citations

Role of phosphodiesterases in the regulation of endothelial permeability in vitro.

1993 • 189 citations

[13] Nitric oxide-cyclic GMP signal transduction system

1996 • 183 citations

Pathways of Macromolecular Extravasation Across Microvascular Endothelium in Response to VPF/VEGF and Other Vasoactive Mediators

1999 • 180 citations

Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade

1993 • 174 citations

Role of RhoA and Rho Kinase in Lysophosphatidic Acid–Induced Endothelial Barrier Dysfunction

2000 • 172 citations

Lysophosphatidic Acid Increases Tight Junction Permeability in Cultured Brain Endothelial Cells

1997 • 172 citations

Extracellular matrix, junctional integrity and matrix metalloproteinase interactions in endothelial permeability regulation*

2002 • 171 citations

Tumor necrosis factor mediates experimental pulmonary edema by ICAM-1 and CD18-dependent mechanisms.

1992 • 170 citations

Regulation of endothelial cell gap formation and paracellular permeability.

1995 • 165 citations

Protein kinase C phosphorylates caldesmon₇₇ and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

1992 • 163 citations

Induction of Endothelial Cell Chemotaxis by Sphingosine 1-Phosphate and Stabilization of Endothelial Monolayer Barrier Function by Lysophosphatidic Acid, Potential Mediators of Hematopoietic Angiogenesis

1999 • 159 citations

Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60^src

1999 • 157 citations

Cytoskeletal Effects of Rho-Like Small Guanine Nucleotide–Binding Proteins in the Vascular System

2001 • 155 citations

Vascular endothelial adhesion molecules and tissue inflammation.

1996 • 155 citations

Simvastatin Improves Disturbed Endothelial Barrier Function

2000 • 147 citations

Phosphorylation of Myosin Light Chain Kinase by p21-activated Kinase PAK2

2000 • 146 citations

Endothelial gaps: time course of formation and closure in inflamed venules of rats

1997 • 145 citations

Microvascular permeability and number of tight junctions are modulated by cAMP

1998 • 144 citations

Nitric oxide signaling: would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone?

1998 • 139 citations

Endothelial Permeability for Macromolecules

1997 • 139 citations

Modulation of venular microvessel permeability by calcium influx into endothelial cells

1992 • 138 citations

Plasmalemmal vesicles represent the large pore system of continuous microvascular endothelium

1993 • 137 citations

The role of cytokines and adhesion molecules in the development of inflammatory injury

1995 • 135 citations

Role of nitric oxide and phosphodiesterase isoenzyme II for reduction of endothelial hyperpermeability

1996 • 133 citations

Vascular Endothelial Growth Factor and Microvascular Permeability

1999 • 131 citations

ROCK mediates thrombin's endothelial barrier dysfunction

2000 • 127 citations

Norepinephrine and iloprost improve barrier function of human endothelial cell monolayers: role of cAMP

1991 • 127 citations

Pretreatment with inhaled nitric oxide inhibits neutrophil migration and oxidative activity resulting in attenuated sepsis-induced acute lung injury

1997 • 123 citations

The effect of histamine and cyclic adenosine monophosphate on myosin light chain phosphorylation in human umbilical vein endothelial cells.

1993 • 122 citations

Expression of cGMP-Dependent Protein Kinase I and Phosphorylation of Its Substrate, Vasodilator-Stimulated Phosphoprotein, in Human Endothelial Cells of Different Origin

1995 • 122 citations

RhoA inactivation enhances endothelial barrier function

1999 • 120 citations

Role of ICAM-1 in neutrophil-mediated lung vascular injury after occlusion and reperfusion

1991 • 106 citations

The beta 2-adrenergic receptor agonist formoterol reduces microvascular leakage by inhibiting endothelial gap formation

1994 • 105 citations

Cyclic-GMP-Mediated Decrease in Permeability of Human Umbilical and Pulmonary Artery Endothelial Cell Monolayers

1994 • 96 citations

Control of systemic capillary leak syndrome with aminophylline and terbutaline

1992 • 96 citations

Effects of inhaled nitric oxide or inhibition of endogenous nitric oxide formation on hyperoxic lung injury.

1997 • 93 citations

Capillary hydraulic conductivity is elevated by cGMP-dependent vasodilators.

1992 • 84 citations

Openings in frog microvascular endothelium induced by high intravascular pressures.

1996 • 80 citations

Openings Through Endothelial Cells Associated with Increased Microvascular Permeability

1999 • 79 citations

Nitric oxide attenuates lung endothelial injury caused by sublethal hyperoxia in rats

1997 • 76 citations

Effects of isoprenaline and cooling on histamine induced changes of capillary permeability in the rat hindquarter vascular bed

1978 • 75 citations

VEGF stimulates tyrosine phosphorylation of β-catenin and small-pore endothelial barrier dysfunction

1999 • 71 citations

Location of focal silver staining at endothelial gaps in inflamed venules examined by scanning electron microscopy

1995 • 69 citations

Differential actions of cAMP on endothelial [Ca2+]i and permeability in microvessels exposed to ATP

1993 • 69 citations

Roles of calcium, cyclic nucleotides, and protein kinase C in regulation of endothelial permeability.

1990 • 63 citations

Macromolecular transport across arterial and venous endothelium in rats. Studies with Evans blue-albumin and horseradish peroxidase.

1990 • 61 citations

High-dose atrial natriuretic factor enhances albumin escape from the systemic but not the pulmonary circulation.

1990 • 60 citations

Opposing roles of cyclic AMP in the vascular control of edema formation

1993 • 58 citations

Capillary leakage in inflammation. A study by vascular labeling.

1990 • 58 citations

Characterization of an In Vitro Model to Study the Permeability of Human Arterial Endothelial Cell Monolayers

1988 • 57 citations

Passage of low density lipoproteins through monolayers of human arterial endothelial cells. Effects of vasoactive substances in an in vitro model.

1989 • 56 citations

cAMP protects endothelial barrier function independent of inhibiting MLC₂₀-dependent tension development

1998 • 55 citations

Atriopeptin inhibition of thrombin-mediated changes in the morphology and permeability of endothelial monolayers.

1989 • 52 citations

Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration.

1986 • 51 citations

Atrial natriuretic peptide inhibits oxidant-induced increases in endothelial permeability

1991 • 49 citations

Thrombin-induced Lung Vascular Injury

1983 • 47 citations

Thrombin inhibits myosin light chain dephosphorylation in endothelial cells

1997 • 44 citations

Protein kinase C β modulates thrombin-induced Ca2+ signaling and endothelial permeability increase

1998 • 43 citations

Functional antagonism between cAMP and cGMP on permeability of coronary endothelial monolayers

1996 • 41 citations

Mechanisms of Thrombin-induced Lung Vascular Injury and Edema

1987 • 40 citations

Platelet lipid(s) bound to albumin increases endothelial electrical resistance: mimicked by LPA

2001 • 39 citations

Activation of Rho Is Involved in the Mechanism of Hydrogen-Peroxide-Induced Lung Edema in Isolated Perfused Rabbit Lung

2001 • 37 citations

Simvastatin, capillary permeability, and acetylcholine-mediated vasomotion in atherosclerotic, hypercholesterolemic men

2000 • 37 citations

Vascular Growth Factors and Angiogenesis

1999 • 35 citations

Histamine alters cadherin-mediated sites of endothelial adhesion

1999 • 32 citations

Dual role of cGMP in modulation of macromolecule permeability of aortic endothelial cells

1997 • 31 citations

Role of intercellular junctions in the passage of horseradish peroxidase across aortic endothelium.

1992 • 29 citations

Treatment of porcine sepsis with high-dose antithrombin III reduces tissue edema and effusion but does not increase risk for bleeding

2001 • 28 citations

Multiple downstream signalling pathways from ROCK, a target molecule of Rho small G protein, in reorganization of the actin cytoskeleton in Madin–Darby canine kidney cells

2000 • 28 citations

Systemic capillary leak syndrome. Preventive treatment with terbutaline.

1988 • 25 citations

Adenosine 3',5'-cyclic monophosphate attenuates neutrophil-mediated increase in endothelial permeability

1993 • 25 citations

Focal arteriolar insudation. A response of arterioles to chronic nonspecific irritation.

1987 • 23 citations

Lung morphological and permeability changes induced by intravascular coagulation in dogs

1987 • 13 citations

Enhancement of barrier function of human aortic endothelial cells by activators of protein kinase C

1996 • 4 citations