Complex roles of tissue inhibitors of metalloproteinases in cancer

Matrix Metalloproteinases

1999 • 3,774 citations

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

1999 • 937 citations

The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis

1999 • 916 citations

Growth‐promoting activity of tissue inhibitor of metalloproteinases‐1 (TIMP‐1) for a wide range of cells A possible new growth factor in serum

1992 • 705 citations

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

1985 • 702 citations

The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A

1998 • 578 citations

Matrix metal loproteinases and the development of cancer

1996 • 569 citations

Molecular Cloning and Characterization of Human Tissue Inhibitor of Metalloproteinase 4

1996 • 547 citations

ECM signalling: orchestrating cell behaviour and misbehaviour

1998 • 537 citations

Macrophage-Derived Metalloelastase Is Responsible for the Generation of Angiostatin in Lewis Lung Carcinoma

1997 • 537 citations

Matrix metalloproteinase inhibitors

1997 • 509 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Cell growth-promoting activity of tissue inhibitor of metalloproteinases-2 (TIMP-2)

1994 • 456 citations

Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization

1998 • 446 citations

Angiostatin-converting Enzyme Activities of Human Matrilysin (MMP-7) and Gelatinase B/Type IV Collagenase (MMP-9)

1997 • 430 citations

Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

1990 • 428 citations

In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1.

1998 • 400 citations

Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.

1994 • 395 citations

Dormancy of Mammary Carcinoma After Mastectomy

1999 • 390 citations

Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model

2000 • 389 citations

Elevated matrix metalloprotease and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization

2000 • 388 citations

Tissue inhibitor of metalloproteinases‐2 inhibits bFGF‐induced human microvascular endothelial cell proliferation

1993 • 362 citations

Tumor Cell Invasion Inhibited by TIMP-2

1991 • 324 citations

Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.

1988 • 312 citations

Binding of Active (57 kDa) Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) to Tissue Inhibitor of Metalloproteinase (TIMP)-2 Regulates MT1-MMP Processing and Pro-MMP-2 Activation

2000 • 310 citations

The generation of endostatin is mediated by elastase.

1999 • 295 citations

In Vivo Evidence That the Stromelysin-3 Metalloproteinase Contributes in a Paracrine Manner to Epithelial Cell Malignancy

1998 • 290 citations

Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3

1999 • 285 citations

TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis

1998 • 274 citations

Regulation of Angiostatin Production by Matrix Metalloproteinase-2 in a Model of Concomitant Resistance

1999 • 274 citations

Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells.

1998 • 268 citations

Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells.

1999 • 256 citations

Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3.

1997 • 253 citations

Growth Stimulation of Human Keratinocytes by Tissue Inhibitor of Metalloproteinases

1991 • 241 citations

Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene.

1996 • 238 citations

Broad Antitumor and Antiangiogenic Activities of AG3340, a Potent and Selective MMP Inhibitor Undergoing Advanced Oncology Clinical Trials

1999 • 234 citations

Inhibition of Collagenolytic Activity and Metastasis of Tumor Cells by a Recombinant Human Tissue Inhibitor of Metalloproteinases

1990 • 233 citations

Suppression of the Tumorigenic and Metastatic Abilities of Murine B16-F10 Melanoma Cells In Vivo by the Overexpression of the Tissue Inhibitor of the Metalloproteinases-1

1994 • 221 citations

Tissue inhibitor of metalloproteinase‐2 (TIMP‐2) has erythroid‐potentiating activity

1992 • 200 citations

Cancer dormancy: Opportunities for new therapeutic approaches

1997 • 192 citations

Expression of MMP-2 and MMP-9, their inhibitors, and the activator MT1-MMP in primary breast carcinomas

1999 • 187 citations

High levels of messenger RNAs for tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in primary breast carcinomas are associated with development of distant metastases.

1997 • 186 citations

Enhanced expression of tissue inhibitor of metalloproteinase‐2 (TIMP‐2) in the stroma of breast carcinomas correlates with tumor recurrence

1994 • 173 citations

Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4

1997 • 169 citations

Serum matrix metalloproteinases -2, -9 and tissue inhibitors of metalloproteinases -1, -2 in lung cancer--TIMP-1 as a prognostic marker.

2000 • 168 citations

Specific, High Affinity Binding of Tissue Inhibitor of Metalloproteinases-4 (TIMP-4) to the COOH-terminal Hemopexin-like Domain of Human Gelatinase A

1997 • 160 citations

Involvement of matrix metalloproteinase-2 activity in invasion and metastasis of pancreatic carcinoma

1998 • 159 citations

Expression and Prognostic Significance of Metalloproteinases and Their Tissue Inhibitors in Patients With Small-Cell Lung Cancer

1999 • 158 citations

High levels of tissue inhibitor of metalloproteinase-1 predict poor outcome in patients with breast cancer

1999 • 150 citations

Elevated tissue inhibitor of metalloproteinase 1 RNA in colorectal cancer stroma correlates with lymph node and distant metastases.

1995 • 150 citations

Plasma Membrane-bound Tissue Inhibitor of Metalloproteinases (TIMP)-2 Specifically Inhibits Matrix Metalloproteinase 2 (Gelatinase A) Activated on the Cell Surface

1998 • 149 citations

Inactivating Mutation of the Mouse Tissue Inhibitor of Metalloproteinases-2(Timp-2) Gene Alters ProMMP-2 Activation

2000 • 147 citations

High preoperative plasma tissue inhibitor of metalloproteinase-1 levels are associated with short survival of patients with colorectal cancer.

2000 • 146 citations

Immunohistochemical localization of matrix metallloproteinase 2 and its specific inhibitor timp‐2 in neoplastic tissues with monclonal antibodies

1994 • 137 citations

Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis.

2001 • 131 citations

Localization of the Death Domain of Tissue Inhibitor of Metalloproteinase-3 to the N Terminus

2000 • 123 citations

Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) Suppresses TKR-Growth Factor Signaling Independent of Metalloproteinase Inhibition

2001 • 123 citations

Stimulation of mammary tumorigenesis by systemic tissue inhibitor of matrix metalloproteinase 4 gene delivery.

2001 • 120 citations

Mammary carcinoma cells over-expressing tissue inhibitor of metalloproteinases-1show vascular endothelial growth factor expression

1998 • 119 citations

Tissue Inhibitor of Metalloproteinase-1 Alters the Tumorigenicity of Burkitt’s Lymphoma via Divergent Effects on Tumor Growth and Angiogenesis

2001 • 118 citations

Human Tissue Inhibitor of Metalloproteinases 3 Interacts with Both the N- and C-terminal Domains of Gelatinases A and B

1999 • 116 citations

MMP-2 and TIMP-2 Expression Correlates with Poor Prognosis in Cervical Carcinoma—A Clinicopathologic Study Using Immunohistochemistry and mRNA in Situ Hybridization

1999 • 115 citations

Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis.

1995 • 114 citations

Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma

1999 • 112 citations

Tyrosine phosphorylation is crucial for growth signaling by tissue inhibitors of metalloproteinases (TIMP‐1 and TIMP‐2)

1996 • 108 citations

Treatment of colorectal liver metastases by adenoviral transfer of tissue inhibitor of metalloproteinases-2 into the liver tissue.

2000 • 108 citations

Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis

1998 • 98 citations

Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Binds to the Cell Surface and Translocates to the Nucleus of Human MCF-7 Breast Carcinoma Cells

1999 • 97 citations

The matrix metalloproteinase inhibitor batimastat inhibits angiogenesis in liver metastases of B16F1 melanoma cells.

1999 • 96 citations

Marimastat: the clinical development of a matrix metalloproteinase inhibitor

2000 • 96 citations

Tissue inhibitor of metalloprotease (TIMP)‐1 and proliferative behaviour of clonal breast cancer cells

1999 • 94 citations

Role of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) in Regulation of Pro-Gelatinase A Activation Catalyzed by Membrane-Type Matrix Metalloproteinase-1 (MT1-MMP) in Human Cancer Cells

1998 • 92 citations

The Propeptide Domain of Membrane Type 1 Matrix Metalloproteinase Is Required for Binding of Tissue Inhibitor of Metalloproteinases and for Activation of Pro-gelatinase A

1998 • 85 citations

Stromal Cell Expression of Components of Matrix-Degrading Protease Systems in Human Cancer

1996 • 81 citations

Inhibition of Endothelial Cell Migration by Gene Transfer of Tissue Inhibitor of Metalloproteinases-1

1999 • 77 citations

Localization and quantification of mRNA for matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in human benign and malignant prostatic tissue

2000 • 76 citations

Differential Roles of TIMP-4 and TIMP-2 in Pro-MMP-2 Activation by MT1-MMP

2001 • 76 citations

Inhibition of metastasis in human gastric cancer cells transfected with tissue inhibitor of metalloproteinase 1 gene in nude mice

1996 • 74 citations

Inhibition of Wilms' tumor growth by intramuscular administration of tissue inhibitor of metalloproteinases-4 plasmid DNA

2001 • 70 citations

Matrix metalloproteinases in remodeling of the normal and neoplastic mammary gland.

1998 • 67 citations

Enhanced RNA expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in human breast cancer

1996 • 63 citations

Evanescent light scattering: The validity of the dipole approximation

1998 • 59 citations

Sequential steps in hematogenous metastasis of cancer cells studied by in vivo videomicroscopy.

1997 • 52 citations

Transfection of an Invasive Human Astrocytoma Cell Line with a TIMP-1 cDNA

1996 • 50 citations

Increased expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) in a more tumourigenic colon cancer cell line

2000 • 49 citations

Expression of tissue inhibitors of metalloproteinases (TIMPs) in gastric cancer.

2000 • 48 citations

Tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 expression in human amnion mesenchymal and epithelial cells

1997 • 48 citations

TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma

1997 • 46 citations

Synthetic inhibitor of matrix metalloproteinases (batimastat) reduces prostate cancer growth in an orthotopic rat model

2000 • 29 citations

Prognostic value of tissue inhibitor of matrix metalloproteinase-1 in plasma of patients with gastric cancer

2000 • 28 citations

Suppression of metastasis by tissue inhibitor of metalloproteinase-1 in a newly established human oral squamous cell carcinoma cell line.

2000 • 20 citations

Metalloproteinases and Tissue Inhibitors of Matrix‐Metalloproteinases in Plasma of Patients with Prostate Cancer and in Prostate Cancer Tissue

1999 • 13 citations

MMPI demise spotlights target choice

2000 • 11 citations

Tissue inhibitor of metalloproteinases-1 (TIMP-1) RNA is expressed at elevated levels in malignant non-Hodgkin's lymphomas

1991 • 8 citations

Cloning and partial structure of the gene encoding human tissue inhibitor of metalloproteinases-3

1996 • 6 citations

Celestial Mechanics Minimum

1999 • 2 citations