Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

1985 • 702 citations

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

1994 • 485 citations

Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis.

1998 • 468 citations

Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases.

1992 • 429 citations

Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

1990 • 428 citations

The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity.

1994 • 342 citations

Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells.

1998 • 268 citations

The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

1992 • 268 citations

Matrix metalloproteinase inhibitor BB-94 (batimastat)inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.

1994 • 254 citations

Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector

1992 • 222 citations

Adenovirus-Mediated Gene Transfer of the Human TIMP-1 Gene Inhibits Smooth Muscle Cell Migration and Neointimal Formation in Human Saphenous Vein

1998 • 196 citations

Murine tissue inhibitor of metalloproteinases—4 (Timp—4): cDNA isolation and expression in adult mouse tissues¹

1997 • 192 citations

Overexpression of Tissue Inhibitor of Matrix Metalloproteinase-1 Inhibits Vascular Smooth Muscle Cell Functions In Vitro and In Vivo

1996 • 191 citations

Effect of Matrix Metalloproteinase Inhibitor Batimastat on Breast Cancer Regrowth and Metastasis in Athymic Mice

1995 • 190 citations

TIMP-3 INDUCES CELL DEATH BY STABILIZING TNF-α RECEPTORS ON THE SURFACE OF HUMAN COLON CARCINOMA CELLS

1997 • 190 citations

Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4

1997 • 169 citations

Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line.

1994 • 168 citations

Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.

1994 • 162 citations

Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth.

1994 • 160 citations

Role of the 21-kDa protein TIMP-3 in oncogenic transformation of cultured chicken embryo fibroblasts.

1992 • 137 citations

A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence.

1994 • 135 citations

Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP‐3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10

1994 • 135 citations

Overexpression of tissue inhibitor of metalloproteinases-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion.

1996 • 134 citations

The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites formation in nude mice.

1996 • 88 citations

Invasion of reconstituted basement membrane matrix is not correlated to the malignant metastatic cell phenotype.

1991 • 87 citations

Inhibition of metastasis in human gastric cancer cells transfected with tissue inhibitor of metalloproteinase 1 gene in nude mice

1996 • 74 citations

Therapeutic effect of the matrix metalloproteinase inhibitor, batimastat, in a human colorectal cancer ascites model

1996 • 60 citations

Development of recombinant adenoviruses that drive high level expression of the human metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 and -2 genes: Characterization of their infection into rabbit smooth muscle cells and human MCF-7 adenocarcinoma cells

1996 • 52 citations

Tissue inhibitor of metalloproteinase-3 expression is upregulated during human cytotrophoblast invasion in vitro

1997 • 46 citations

In situ detection of PCR-amplified metalloproteinase cDNAS, their inhibitors and human papillomavirus transcripts in cervical carcinoma cell lines

1997 • 40 citations

The Tissue Inhibitor of Metalloproteinases-3 Gene in Breast Carcinoma: Identification of Multiple Polyadenylation Sites and a Stromal Pattern of Expression

1995 • 39 citations

Lack of suppression of tumor cell phenotype by overexpression of TIMP-3 in mouse JB6 tumor cells identification of a transfectant with increased tumorigenicity and invasiveness.

1996 • 36 citations