Disruption of ionic and cell volume homeostasis in cerebral ischemia: The perfect storm

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Pathobiology of ischaemic stroke: an integrated view

1999 • 3,776 citations

Ischemic Cell Death in Brain Neurons

1999 • 2,974 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Excitotoxic cell death

1992 • 2,307 citations

Functional Significance of Cell Volume Regulatory Mechanisms

1998 • 1,871 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Sodium/Calcium Exchange: Its Physiological Implications

1999 • 1,690 citations

Mechanisms, challenges and opportunities in stroke

2003 • 1,688 citations

Viability thresholds and the penumbra of focal ischemia

1994 • 1,358 citations

Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor

2000 • 1,348 citations

Molecular Structure and Physiological Function of Chloride Channels

2002 • 1,234 citations

Sodium-Potassium-Chloride Cotransport

2000 • 901 citations

Calcium in Ischemic Cell Death

1998 • 818 citations

Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake

1990 • 728 citations

NMDA receptors are expressed in oligodendrocytes and activated in ischaemia

2005 • 716 citations

Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures

1990 • 689 citations

Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger

1992 • 656 citations

Volume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor

1997 • 652 citations

Diversity of the mammalian sodium/proton exchanger SLC9 gene family

2004 • 637 citations

The neurotoxicity of excitatory amino acids is produced by passive chloride influx

1985 • 634 citations

Cellular and molecular physiology of volume-sensitive anion channels

1996 • 620 citations

NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury

2005 • 530 citations

Receptor‐mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD)

2001 • 523 citations

Ischemic lesion volumes in acute stroke by diffusion‐weighted magnetic resonance imaging correlate with clinical outcome

1997 • 471 citations

TRPV4 calcium entry channel: a paradigm for gating diversity

2004 • 469 citations

An overview of inhibitors of Na+/H+ exchanger

2003 • 423 citations

Myocardial Protection at a Crossroads

2004 • 419 citations

Current concepts of brain edema

1995 • 412 citations

The Myocardial Na ⁺ -H ⁺ Exchange

1999 • 403 citations

Amazing chloride channels: an overview

2003 • 401 citations

Treatment of Acute Ischemic Stroke

2000 • 391 citations

Neuroprotection for ischemic stroke: Two decades of success and failure

2004 • 376 citations

Calcium signaling in cell volume regulation

1992 • 349 citations

SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.

2001 • 337 citations

Rapid Ischemic Cell Death in Immature Oligodendrocytes: A Fatal Glutamate Release Feedback Loop

2000 • 320 citations

General mechanisms of axonal damage and its prevention

2005 • 300 citations

The role of specific ions in glutamate neurotoxicity

1986 • 298 citations

Pharmacology of Brain Na⁺/Ca²⁺Exchanger: From Molecular Biology to Therapeutic Perspectives

2004 • 297 citations

Bumetanide Inhibition of the Blood-Brain Barrier Na-K-Cl Cotransporter Reduces Edema Formation in the Rat Middle Cerebral Artery Occlusion Model of Stroke

2004 • 239 citations

Identification of Major Ischemic Change

1999 • 233 citations

Cation-Chloride Cotransporters in Neuronal Communication

2000 • 232 citations

Mechanosensitivity of NMDA receptors in cultured mouse central neurons

1994 • 227 citations

Inhibition of Ischemia-Induced Glutamate Release in Rat Striatum by Dihydrokinate and an Anion Channel Blocker

1999 • 202 citations

DCPIB is a novel selective blocker of I_Cl,swell and prevents swelling‐induced shortening of guinea‐pig atrial action potential duration

2001 • 176 citations

Astrocytes from Na⁺-K⁺-Cl⁻cotransporter-null mice exhibit absence of swelling and decrease in EAA release

2002 • 174 citations

Anion channels for amino acids in MDCK cells

1992 • 172 citations

Two Sodium/Calcium Exchanger Gene Products, NCX1 and NCX3, Play a Major Role in the Development of Permanent Focal Cerebral Ischemia

2004 • 166 citations

The volume-sensitive organic osmolyte-anion channel VSOAC is regulated by nonhydrolytic ATP binding

1994 • 156 citations

Cell Swelling and a Nonselective Cation Channel Regulated by Internal Ca²⁺and ATP in Native Reactive Astrocytes from Adult Rat Brain

2001 • 152 citations

Contribution of Na⁺-K⁺-Cl⁻cotransporter to high-[K⁺]_o- induced swelling and EAA release in astrocytes

2002 • 141 citations

Na⁺-Dependent Chloride Transporter (NKCC1)-Null Mice Exhibit Less Gray and White Matter Damage after Focal Cerebral Ischemia

2005 • 138 citations

Na-K-Cl Cotransporter Contributes to Glutamate-Mediated Excitotoxicity

2003 • 135 citations

Neuroimaging, the ischaemic penumbra, and selection of patients for acute stroke therapy

2002 • 132 citations

The Chloride Transporter Na⁺-K⁺-Cl⁻Cotransporter Isoform-1 Contributes to Intracellular Chloride Increases afterIn VitroIschemia

2006 • 125 citations

Increased tolerance to oxygen and glucose deprivation in astrocytes from Na⁺/H⁺ exchanger isoform 1 null mice

2004 • 125 citations

Pharmacological comparison of swelling‐activated excitatory amino acid release and Cl⁻ currents in cultured rat astrocytes

2006 • 123 citations

Inhibition of Na+/Ca2+ exchange enhances delayed neuronal death elicited by glutamate in cerebellar granule cell cultures

1991 • 122 citations

Membrane Reserves and Hypotonic Cell Swelling

2006 • 121 citations

Important Role of Reverse Na⁺-Ca²⁺Exchange in Spinal Cord White Matter Injury at Physiological Temperature

2000 • 121 citations

Mechanisms of cell volume regulation and possible nature of the cell volume sensor

2001 • 116 citations

ATP potently modulates anion channel-mediated excitatory amino acid release from cultured astrocytes

2002 • 116 citations

Volume-Regulated Anion Channels Are the Predominant Contributors to Release of Excitatory Amino Acids in the Ischemic Cortical Penumbra

2004 • 115 citations

Emerging roles of alkali cation/proton exchangers in organellar homeostasis

2007 • 113 citations

Decreased Neuronal Death in Na⁺/H⁺Exchanger Isoform 1-Null Mice afterIn VitroandIn VivoIschemia

2005 • 113 citations

New Light on White Matter

2003 • 113 citations

Release of [³H]-d-Aspartate from Primary Astrocyte Cultures in Response to Raised External Potassium

1996 • 112 citations

Correlation of Apparent Diffusion Coefficient and Computed Tomography Density in Acute Ischemic Stroke

2002 • 112 citations

Acute treatment with tamoxifen reduces ischemic damage following middle cerebral artery occlusion

2000 • 109 citations

Evidence for a protective role played by the Na+/Ca2+ exchanger in cerebral ischemia induced by middle cerebral artery occlusion in male rats

2003 • 106 citations

Inhibition by anion channel blockers of ischemia-evoked release of excitotoxic and other amino acids from rat cerebral cortex

1997 • 105 citations

Na⁺-K⁺-Cl⁻ Cotransporter in Rat Focal Cerebral Ischemia

2001 • 105 citations

Expression of Na+-K+-Cl− cotransporter in rat brain during development and its localization in mature astrocytes

2001 • 102 citations

Inhibition of volume regulation and efflux of osmoregulatory amino acids by blockers of Cl− transport in cultured astrocytes

1993 • 101 citations

Regional Variations in the Apparent Diffusion Coefficient and the Intracellular Distribution of Water in Rat Brain During Acute Focal Ischemia

2001 • 101 citations

Volume-activated Cl− currents in different mammalian non-excitable cell types

1994 • 100 citations

Regulatory volume decrease in cultured astrocytes. II. Permeability pathway to amino acids and polyols

1994 • 97 citations

Blockade of NMDA channels in acutely isolated rat hippocampal neurons by the Na+/Ca2+ exchange inhibitor KB-R7943

1999 • 88 citations

Roles of Volume-Sensitive Chloride Channel in Excitotoxic Neuronal Injury

2007 • 86 citations

The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury

1999 • 84 citations

Neuroprotective activity of tamoxifen in permanent focal ischemia

2003 • 82 citations

Involvement of Na⁺–Ca²⁺ Exchanger in Reperfusion‐induced Delayed Cell Death of Cultured Rat Astrocytes

1996 • 81 citations

Apoptosis: Future Targets for Neuroprotective Strategies

2006 • 79 citations

Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity

2007 • 78 citations

Amino acid current through anion channels in cultured human glial cells

1995 • 78 citations

Excitotoxic death induced by released glutamate in depolarized primary cultures of mouse cerebellar granule cells is dependent on GABA_A receptors and niflumic acid‐sensitive chloride channels

2005 • 78 citations

Tamoxifen, a chloride channel blocker, reduces glutamate and aspartate release from the ischemic cerebral cortex

1998 • 77 citations

Real-time measurement of free Ca2+ changes in CNS myelin by two-photon microscopy

2007 • 72 citations

Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat

2001 • 70 citations

Swelling-Activated Release of Excitatory Amino Acids in the Brain: Relevance for Pathophysiology

1998 • 69 citations

NMDA Receptor Activation Inhibits Neuronal Volume Regulation after Swelling Induced by Veratridine-Stimulated Na⁺Influx in Rat Cortical Cultures

1996 • 68 citations

Volume‐sensitive chloride channels in mouse cortical neurons: characterization and role in volume regulation

2005 • 68 citations

Astrocyte swelling leads to membrane unfolding, not membrane insertion

2006 • 67 citations

Anoxie Injury in the Rat Spinal Cord: Pharmacological Evidence for Multiple Steps in Ca²⁺-Dependent Injury of the Dorsal Columns

1997 • 66 citations

Excitotoxic Cell Death Dependent on Inhibitory Receptor Activation

1999 • 65 citations

Protection of ischemic rat spinal cord white matter: Dual action of KB-R7943 on Na+/Ca2+ exchange and L-type Ca2+ channels

2005 • 64 citations

Characterization of transient focal ischemia-induced increases in extracellular glutamate and aspartate in spontaneously hypertensive rats

2000 • 62 citations

Behavioral and histological neuroprotection by tamoxifen after reversible focal cerebral ischemia

2005 • 60 citations

Cell Volume-Sensitive Chloride Channels: Phenotypic Properties and Molecular Identity

2006 • 59 citations

Life After Cerovive

2007 • 55 citations

In depolarized and glucose‐deprived neurons, Na⁺ influx reverses plasmalemmal K⁺‐dependent and K⁺‐independent Na⁺/Ca²⁺ exchangers and contributes to NMDA excitotoxicity

2002 • 54 citations

5-(N-Ethyl-N-isopropyl)-amiloride, an Na+–H+ exchange inhibitor, protects gerbil hippocampal neurons from ischemic injury

1999 • 51 citations

Thrombin potently enhances swelling‐sensitive glutamate efflux from cultured astrocytes

2007 • 50 citations

Glutamate-induced neuronal death in cerebellar culture is mediated by two distinct components: a sodium-chloride component and a calcium component

1994 • 49 citations

Pharmacological evidence that the activation of the Na⁺‐Ca²⁺ exchanger protects C6 glioma cells during chemical hypoxia

1997 • 49 citations

Cerebroprotective properties of SM-20220, a potent Na+/H+ exchange inhibitor, in transient cerebral ischemia in rats

1999 • 49 citations

Acute Ischemic Injury of Astrocytes Is Mediated by Na-K-Cl Cotransport and not Ca²⁺Influx at a Key Point in White Matter Development

2004 • 49 citations

Mechanism of Acute Ischemic Injury of Oligodendroglia in Early Myelinating White Matter: The Importance of Astrocyte Injury and Glutamate Release

2004 • 48 citations

Chloride Influx Aggravates Ca²⁺-Dependent AMPA Receptor-Mediated Motoneuron Death

2003 • 47 citations

Hydrogen Peroxide Potentiates Volume-sensitive Excitatory Amino Acid Release via a Mechanism Involving Ca2+/Calmodulin-dependent Protein Kinase II

2004 • 45 citations

Inhibition of ligand-gated cation-selective channels by tamoxifen

1998 • 41 citations

Peroxynitrite enhances astrocytic volume‐sensitive excitatory amino acid release via a src tyrosine kinase‐dependent mechanism

2002 • 39 citations

Swelling-induced K+ influx in cultured primary astrocytes

1994 • 37 citations

Astrocytic Swelling in Neuropathology

2004 • 34 citations

Reduction in ischemic brain injury in rabbits by the anion transport inhibitor L-644,711.

1992 • 29 citations

The role of membrane ion transport proteins in cerebral ischemic damage

2006 • 29 citations

Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia

2005 • 26 citations

ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload

2006 • 25 citations

Swelling-induced activation of Na+,K+,2Cl− cotransport in C6 glioma cells: kinetic properties and intracellular signalling mechanisms

1996 • 24 citations

Na+/H+ Exchange Inhibitor SM-20220 Improves Endothelial Dysfunction Induced by Ischemia-Reperfusion

2001 • 21 citations

5-(N-Ethyl-N-isopropyl)-amiloride inhibits amino acid release from the ischemic rat cerebral cortex: role of Na+–H+ exchange

1998 • 16 citations

Na ⁺ /Ca ²⁺ Exchanger Maintains Ionic Homeostasis in the Peri-Infarct Area

2007 • 12 citations

Bepridil-induced Blockade of NMDA Channels in Rat Hippocampal Neurones

1997 • 12 citations

Osmotic regulation of sodium pump in rat brain synaptosomes: the role of cytoplasmic sodium

1994 • 11 citations

Inhibitory effect of SM-20550, an Na + /H + exchange inhibitor, on accumulation of leukocytes in ischemia and reperfusion

2001 • 8 citations

[Osmotic regulation of the sodium pump in rat brain synaptosomes].

1992 • 7 citations