General mechanisms of axonal damage and its prevention

The versatility and universality of calcium signalling

2000 • 5,407 citations

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Glutamate: A Neurotransmitter in Mammalian Brain

1984 • 1,981 citations

Multiple sclerosis

2002 • 1,678 citations

Molecular and cellular physiology of intracellular calcium stores

1994 • 1,132 citations

Ryanodine Receptor Calcium Release Channels

2002 • 1,060 citations

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

1994 • 988 citations

Involvement of dihydropyridine receptors in excitation–contraction coupling in skeletal muscle

1987 • 887 citations

Nonvesicular release of neurotransmitter

1993 • 837 citations

Flux coupling in a neuronal glutamate transporter

1996 • 835 citations

Glutamate excitotoxicity in a model of multiple sclerosis

2000 • 832 citations

Functional Hemichannels in Astrocytes: A Novel Mechanism of Glutamate Release

2003 • 697 citations

Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger

1992 • 656 citations

Pathophysiology of Cerebral Ischemia and Brain Trauma: Similarities and Differences

2004 • 621 citations

The local differentiation of myelinated axons at nodes of Ranvier

2003 • 597 citations

Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease

2003 • 569 citations

The role of nitric oxide in multiple sclerosis

2002 • 521 citations

Autoimmune encephalomyelitis ameliorated by AMPA antagonists

2000 • 467 citations

Intracellular calcium-binding proteins: more sites than insights

1991 • 458 citations

Stoichiometry of the Glial Glutamate Transporter GLT-1 Expressed Inducibly in a Chinese Hamster Ovary Cell Line Selected for Low Endogenous Na⁺-Dependent Glutamate Uptake

1998 • 454 citations

Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro.

1990 • 410 citations

NBQX Attenuates Excitotoxic Injury in Developing White Matter

2000 • 388 citations

Axon pathology in neurological disease: a neglected therapeutic target

2002 • 386 citations

'New' functions for 'old' proteins: The role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice

2002 • 383 citations

Ion Channels In Vertebrate Glia

1990 • 373 citations

Nitric oxide inhibition of mitochondrial respiration and its role in cell death

2002 • 372 citations

Astrocytic Glycogen Influences Axon Function and Survival during Glucose Deprivation in Central White Matter

2000 • 364 citations

Molecular dissection of the myelinated axon

1993 • 352 citations

News on glutamate receptors in glial cells

1996 • 337 citations

Rapid Ischemic Cell Death in Immature Oligodendrocytes: A Fatal Glutamate Release Feedback Loop

2000 • 320 citations

Myelin Biology and Disorders

2004 • 315 citations

Electrically active axons degenerate when exposed to nitric oxide

2001 • 308 citations

Oligodendrocytes and Ischemic Brain Injury

2003 • 307 citations

Mechanisms of Ionotropic Glutamate Receptor-Mediated Excitotoxicity in Isolated Spinal Cord White Matter

2000 • 292 citations

Anoxic and Ischemic Injury of Myelinated Axons in CNS White Matter: From Mechanistic Concepts to Therapeutics

1998 • 290 citations

AMPA/Kainate Receptor Activation Mediates Hypoxic Oligodendrocyte Death and Axonal Injury in Cerebral White Matter

2001 • 259 citations

Novel Injury Mechanism in Anoxia and Trauma of Spinal Cord White Matter: Glutamate Release via Reverse Na⁺-dependent Glutamate Transport

1999 • 250 citations

White Matter Injury Mechanisms

2004 • 246 citations

Glycogen Regulation and Functional Role in Mouse White Matter

2003 • 239 citations

Role of NMDA and Non-NMDA Ionotropic Glutamate Receptors in Traumatic Spinal Cord Axonal Injury

1997 • 227 citations

Hypoxia-like tissue injury as a component of multiple sclerosis lesions

2003 • 220 citations

Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo

1993 • 216 citations

Role of extracellular calcium in anoxic injury of mammalian central white matter.

1990 • 212 citations

Noninactivating, tetrodotoxin-sensitive Na+ conductance in rat optic nerve axons.

1993 • 210 citations

Calcium signaling of glial cells along mammalian axons

1993 • 204 citations

Depolarization-Induced Ca2+ Release in Ischemic Spinal Cord White Matter Involves L-type Ca2+ Channel Activation of Ryanodine Receptors

2003 • 193 citations

Axonal protection using flecainide in experimental autoimmune encephalomyelitis

2004 • 192 citations

Calcium stores in neurons and glia

1994 • 183 citations

Phenytoin Protects Spinal Cord Axons and Preserves Axonal Conduction and Neurological Function in a Model of Neuroinflammation In Vivo

2003 • 181 citations

Na+ currents that fail to inactivate

1993 • 160 citations

Excitotoxicity in glial cells

2002 • 132 citations

Important Role of Reverse Na⁺-Ca²⁺Exchange in Spinal Cord White Matter Injury at Physiological Temperature

2000 • 121 citations

Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability

1992 • 121 citations

Nitric oxide toxicity in CNS white matter: an in vitro study using rat optic nerve

2002 • 115 citations

New Light on White Matter

2003 • 113 citations

Interactions between mitochondrial bioenergetics and cytoplasmic calcium in cultured cerebellar granule cells

2003 • 109 citations

AMPA receptor activation is rapidly toxic to cortical astrocytes when desensitization is blocked

1996 • 108 citations

Glutamate receptor agonists stimulate diverse calcium responses in different types of cultured rat cortical glial cells

1994 • 99 citations

Multiple Sclerosis and Glutamate

2003 • 98 citations

Molecular mechanisms of axonal damage in inflammatory central nervous system diseases

2003 • 97 citations

Glutamate-, kainate- and NMDA-evoked membrane currents in identified glial cells in rat spinal cord slice.

1998 • 95 citations

Protection of the axonal cytoskeleton in anoxic optic nerve by decreased extracellular calcium

1993 • 88 citations

Oligodendroglial lineage cells express neuroligand receptors

1993 • 87 citations

L-TRANs-Pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1, 3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters

1994 • 85 citations

Transient presence and functional interaction of endogenous GABA and GABA _A receptors in developing rat optic nerve

1992 • 84 citations

Expression of Kainate‐selective Glutamate Receptor Subunits in Glial Cells of the Adult Bovine White Matter

1996 • 83 citations

Axon Conduction and Survival in CNS White Matter During Energy Deprivation: A Developmental Study

1998 • 82 citations

Current‐clamp analysis of a time‐dependent rectification in rat optic nerve.

1990 • 82 citations

Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis

2002 • 81 citations

Molecular mechanisms of axonal damage in inflammatory central nervous system diseases

2003 • 78 citations

Elemental composition and water content of rat optic nerve myelinated axons and glial cells: effects of in vitro anoxia and reoxygenation

1995 • 77 citations

Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation.

1987 • 75 citations

NMDA Receptor Blockade Fails to Alter Axonal Injury in Focal Cerebral Ischemia

2000 • 71 citations

Anoxia-Induced Changes in Extracellular K⁺and pH in Mammalian Central White Matter

1992 • 71 citations

Na channel activation gate modulates slow recovery from use-dependent block by local anesthetics in squid giant axons

1985 • 71 citations

Role of Group I Metabotropic Glutamate Receptors in Traumatic Spinal Cord White Matter Injury

1998 • 71 citations

Anoxie Injury in the Rat Spinal Cord: Pharmacological Evidence for Multiple Steps in Ca²⁺-Dependent Injury of the Dorsal Columns

1997 • 66 citations

Protection of ischemic rat spinal cord white matter: Dual action of KB-R7943 on Na+/Ca2+ exchange and L-type Ca2+ channels

2005 • 64 citations

Oligodendrocytes and Ischemic Brain Injury

2003 • 63 citations

N-Type Calcium Channels and Their Regulation by GABA_BReceptors in Axons of Neonatal Rat Optic Nerve

1999 • 62 citations

Modulation of anoxic injury in CNS white matter by adenosine and interaction between adenosine and GABA

1994 • 58 citations

Endogenous GABA attenuates CNS white matter dysfunction following anoxia

1995 • 54 citations

Intracellular Concentrations of Major Ions in Rat Myelinated Axons and Glia: Calculations Based on Electron Probe X‐Ray Microanalyses

1997 • 50 citations

Ion Transport and Membrane Potential in CNS Myelinated Axons II. Effects of Metabolic Inhibition

1997 • 49 citations

AMPA-selective glutamate receptor subunits in glial cells of the adult bovine white matter

1998 • 46 citations

Nitric oxide and the axonal death cascade

2003 • 42 citations

Ionic Mechanisms of Aglycemic Axon Injury in Mammalian Central White Matter

2001 • 40 citations

Non-synaptic modulation of dorsal column conduction by endogenous GABA in neonatal rat spinal cord

1993 • 38 citations

Calcium imaging in live rat optic nerve myelinated axons in vitro using confocal laser microscopy

2000 • 34 citations

Nicotinic Acetylcholine Receptors in Mouse and Rat Optic Nerves

2004 • 29 citations

(±)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid and kainate receptor subunit expression in mouse versus rat spinal cord white matter: similarities in astrocytes but differences in oligodendrocytes

2003 • 25 citations

Role of Inactivation in Local Anesthetic Action

1991 • 24 citations

Organization of the cortical endoplasmic reticulum in the squid giant axon.

1997 • 24 citations

Elemental composition and water content of rat optic nerve myelinated axons during in vitro post-anoxia reoxygenation

1996 • 22 citations

Calcium signalling: NAADP comes out of the shadows

2003 • 21 citations

Effects of K+ channel blockers on the anoxic response of CNS myelinated axons

1998 • 17 citations