Receptor‐mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD)

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Apoptosis by Death Factor

1997 • 5,038 citations

The Fas Death Factor

1995 • 4,070 citations

Ischemic Cell Death in Brain Neurons

1999 • 2,974 citations

Caspases: killer proteases

1997 • 2,440 citations

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Functional Significance of Cell Volume Regulatory Mechanisms

1998 • 1,871 citations

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

1999 • 1,309 citations

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

1993 • 1,259 citations

Glutamate release in severe brain ischaemia is mainly by reversed uptake

2000 • 1,105 citations

Membrane mechanisms in volume and pH regulation in vertebrate cells

1989 • 880 citations

Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis

2000 • 707 citations

Regulation of Cell Volume by Active Cation Transport in High and Low Potassium Sheep Red Cells

1960 • 671 citations

Volume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor

1997 • 652 citations

A mammalian two pore domain mechano-gated S-like K+ channel

1998 • 627 citations

Cellular and molecular physiology of volume-sensitive anion channels

1996 • 620 citations

Death and the cell

1986 • 616 citations

Regulation of cellular volume.

1977 • 607 citations

Mediation of Neuronal Apoptosis by Enhancement of Outward Potassium Current

1997 • 574 citations

The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

1996 • 564 citations

Properties of volume-regulated anion channels in mammalian cells

1997 • 357 citations

Calcium signaling in cell volume regulation

1992 • 349 citations

Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.

1996 • 328 citations

The apoptosis cascade -- morphological and immunohistochemical methods for its visualization

1999 • 316 citations

Mechanisms underlying hypoxia-induced neuronal apoptosis

2000 • 306 citations

Caspase Independent/Dependent Regulation of K+, Cell Shrinkage, and Mitochondrial Membrane Potential during Lymphocyte Apoptosis

1999 • 297 citations

Activation of Sphingosine Kinase by Tumor Necrosis Factor-α Inhibits Apoptosis in Human Endothelial Cells

1999 • 270 citations

Bioluminescence detection of ATP release mechanisms in epithelia

1998 • 242 citations

A release mechanism for stored ATP in ocular ciliary epithelial cells

1998 • 233 citations

Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes

1996 • 227 citations

Tyrosine Phosphorylation-dependent Suppression of a Voltage-gated K+ Channel in T Lymphocytes upon Fas Stimulation

1996 • 225 citations

Ca2+ sensitivity of volume‐regulatory K+ and Cl‐ channels in cultured human epithelial cells.

1988 • 223 citations

Localization of the extracellular Ca(2+)-sensing receptor and PTH/PTHrP receptor in rat kidney

1996 • 219 citations

The Extracellular Calcium-Sensing Receptor: Its Role in Health and Disease

1998 • 218 citations

hSK4/hIK1, a Calmodulin-binding KCa Channel in Human T Lymphocytes

1999 • 216 citations

Hypotonicity activates a native chloride current in Xenopus oocytes.

1994 • 216 citations

Calcium-Sensing Receptor in Mature Osteoclasts, Which Are Bone Resorbing Cells

1998 • 216 citations

Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances.

1993 • 211 citations

Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes

1998 • 200 citations

MAINTENANCE OF CONCENTRATION GRADIENTS AND REGULATION OF CELL VOLUME

1959 • 197 citations

Activation of a Cl- current by hypotonic volume increase in human endothelial cells.

1994 • 187 citations

Volume‐regulatory Cl‐ channel currents in cultured human epithelial cells.

1992 • 185 citations

Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis.

1994 • 184 citations

Swelling-induced chloride-sensitive current in canine atrial cells revealed by whole-cell patch-clamp method.

1992 • 184 citations

Activation of the osmo-sensitive chloride conductance involves P21rho and is accompanied by a transient reorganization of the F-actin cytoskeleton.

1996 • 171 citations

Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death

1996 • 169 citations

Mitogen-Activated Protein and Tyrosine Kinases in the Activation of Astrocyte Volume-Activated Chloride Current

1998 • 166 citations

Hepatocellular ATP-binding Cassette Protein Expression Enhances ATP Release and Autocrine Regulation of Cell Volume

1997 • 165 citations

Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins

1996 • 162 citations

The Tyrosine Kinase p56lck Mediates Activation of Swelling-induced Chloride Channels in Lymphocytes

1998 • 161 citations

Regulation of a swelling‐activated chloride current in bovine endothelium by protein tyrosine phosphorylation and G proteins

1998 • 160 citations

Differential expression of volume‐regulated anion channels during cell cycle progression of human cervical cancer cells

2000 • 160 citations

High Extracellular Calcium Inhibits Osteoclast-like Cell Formation by Directly Acting on the Calcium-Sensing Receptor Existing in Osteoclast Precursor Cells

1999 • 159 citations

Role of Potassium Channels in Amyloid‐Induced Cell Death

1998 • 154 citations

Human eosinophils in culture undergo a striking and rapid shrinkage during apoptosis. Role of K+ channels

1995 • 146 citations

Fas and Fas ligand in gut and liver

2000 • 143 citations

Volume‐sensitive chloride conductance in bovine chromaffin cell membrane.

1992 • 141 citations

Role of Rho and Rho kinase in the activation of volume‐regulated anion channels in bovine endothelial cells

1999 • 140 citations

The caspase-RB connection in cell death

1998 • 138 citations

Intercellular communication mediated by the extracellular calcium-sensing receptor

2000 • 136 citations

Swelling-Induced, Cftr-Independent Atp Release from a Human Epithelial Cell Line

1999 • 130 citations

Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux

1997 • 121 citations

Characterization of the voltage-dependent properties of a volume-sensitive anion conductance.

1995 • 118 citations

Role of prostaglandins and leukotrienes in volume regulation by Ehrlich ascites tumor cells

1987 • 118 citations

Characterization of cell volume loss in CEM-C7A cells during dexamethasone-induced apoptosis

1996 • 114 citations

Phosphatidylinositol 3-Kinase Contributes to Cell Volume Regulation through Effects on ATP Release

1998 • 114 citations

Activation of Potassium and Chloride Channels by Tumor Necrosis Factor α

2000 • 113 citations

Plasma membrane potential in thymocyte apoptosis.

1999 • 112 citations

Tyrosine protein kinase inhibitors prevent activation of cardiac swelling-induced chloride current

1995 • 105 citations

Endogenous ATP release regulates Cl⁻secretion in cultured human and rat biliary epithelial cells

1999 • 101 citations

Plasma Membrane Potential in Thymocyte Apoptosis

1999 • 97 citations

Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.

1990 • 96 citations

Cell Volume Regulation

1998 • 96 citations

An Ultraviolet-activated K+ Channel Mediates Apoptosis Of Myeloblastic Leukemia Cells

1999 • 96 citations

Antisense oligonucleotides suppress cell-volume-induced activation of chloride channels

1995 • 93 citations

Perspective: Molecular Identity of the Outwardly Rectifying, Swelling-activated Anion Channel: Time to Reevaluate pICln

1998 • 90 citations

Swelling‐activated, cystic fibrosis transmembrane conductance regulator‐augmented ATP release and Cl⁻ conductances in murine C127 cells

2000 • 88 citations

The Temporal Relationship between Protein Phosphatase, ICE/CED-3 Proteases, Intracellular Acidification, and DNA Fragmentation in Apoptosis

1997 • 82 citations

Cellular taurine release triggered by stimulation of the Fas(CD95) receptor in Jurkat lymphocytes

1998 • 80 citations

Evidence against Volume Regulation by Cortical Brain Cells during Acute Osmotic Stress

1997 • 77 citations

Forskolin Stimulates Swelling-Induced Chloride Current, Not Cardiac Cystic Fibrosis Transmembrane-Conductance Regulator Current, in Human Cardiac Myocytes

1995 • 74 citations

A Physical Interaction between the Cell Death Protein Fas and the Tyrosine Kinase p59

1996 • 73 citations

Permeation properties and modulation of volume‐activated Cl⁻‐currents in human endothelial cells

1994 • 68 citations

Cell volume regulation in cultured cerebellar granule neurons

1993 • 68 citations

NMDA Receptor Activation Inhibits Neuronal Volume Regulation after Swelling Induced by Veratridine-Stimulated Na⁺Influx in Rat Cortical Cultures

1996 • 68 citations

Tumor necrosis factor enhancement of transient outward potassium currents in cultured rat cortical neurons

1997 • 68 citations

Activation of a novel non‐selective cation channel by alloxan and H₂O₂ in the rat insulin‐secreting cell line CRI‐G1

1997 • 67 citations

Distinctive Functions of Syk and Lyn in Mediating Osmotic Stress- and Ultraviolet C Irradiation-induced Apoptosis in Chicken B Cells

1997 • 65 citations

Volume-sensitive chloride current in pigmented ciliary epithelial cells: role of phospholipases

1997 • 65 citations

Volume-regulated chloride conductance in the LNCaP human prostate cancer cell line

2000 • 64 citations

Receptor-Mediated Facilitation of Cell Volume Regulation by Swelling-Induced ATP Release in Human Epithelial Cells.

2000 • 64 citations

Apoptosis in Vascular Smooth Muscle Cells: Role of Cell Shrinkage

1996 • 63 citations

Volume changes induced by osmotic stress in freshly isolated rat hippocampal neurons

1998 • 62 citations

Nonselective cation channels as effectors of free radical–induced rat liver cell necrosis

2001 • 61 citations

Downregulation of volume-activated Cl- currents during muscle differentiation

1997 • 61 citations

Glucocorticoid-induced thymocyte apoptosis: protease-dependent activation of cell shrinkage and DNA degradation

1998 • 60 citations

Role for Lyn Tyrosine Kinase as a Regulator of Stress-Activated Protein Kinase Activity in Response to DNA Damage

2000 • 59 citations

Osmotic cell swelling-induced ATP release mediates the activationof extracellular signal-regulated protein kinase (Erk)-1/2 but not the activation of osmo-sensitive anion channels

1999 • 58 citations

Activation of Src-family tyrosine kinases during Fas-induced apoptosis

1996 • 57 citations

Swelling and Volume Control in Brain Astroglial Cells

1991 • 56 citations

Sensors and Signal Transduction in the Activation of Cell Volume Regulatory Ion Transport Systems

1998 • 55 citations

A swelling‐activated chloride current in rat sympathetic neurones

1997 • 54 citations

Sensitivity of volume-sensitive Cl- conductance in human epithelial cells to extracellular nucleotides

1996 • 54 citations

Biphasic rises in cytosolic free Ca2+ in association with activation of K+ and Cl? conductance during the regulatory volume decrease in cultured human epithelial cells

1990 • 53 citations

Role of caspases and possible involvement of retinoblastoma protein during TGFβ-mediated apoptosis of human B lymphocytes

1999 • 52 citations

Near‐visible ultraviolet light induces a novel ubiquitous calcium‐permeable cation current in mammalian cell lines

1998 • 51 citations

Studies on the Mechanisms and Kinetics of Apoptosis Induced by Microinjection of Cytochrome c in Rat Kidney Tubule Epithelial Cells (NRK-52E)

2000 • 51 citations

Oxidized glutathione mediates cation channel activation in calf vascular endothelial cells during oxidant stress.

1996 • 51 citations

Two-stage Cell Shrinkage and the OER for Radiation-induced Apoptosis of Rat Thymocytes

1993 • 51 citations

Involvement of Ca2+-induced Ca2+ release in the volume regulation of human epithelial cells exposed to a hypotonic medium

1990 • 51 citations

Characterization of volume-sensitive taurine- and Cl(-)-permeable channels

1997 • 50 citations

Chloride current activated by swelling in retinal pigment epithelium cells

1993 • 50 citations

Extracellular ATP stimulates volume decrease inNecturus red blood cells

1999 • 48 citations

Lack of internucleosomal DNA fragmentation is related to C1⁻efflux impairment in hematopoietic cell apoptosis

1999 • 46 citations

Cell physiology: Source book

1997 • 45 citations

Mg2+ and ATP-dependence of volume-sensitive Cl- channels in human epithelial cells.

1994 • 45 citations

Swelling‐ and cAMP‐Activated Cl⁻ Currents in Isolated Rat Carotid Body Type I Cells

1997 • 44 citations

Role of LTD 4 in the Regulatory Volume Decrease Response in Ehrlich Ascites Tumor Cells

1996 • 44 citations

cAMP- and swelling-activated chloride conductance in rat hepatocytes

1996 • 43 citations

Autocrine Regulation of Volume-sensitive Anion Channels in Airway Epithelial Cells by Adenosine

1999 • 42 citations

Induction of apoptosis using sphingolipids activates a chloride current inXenopus laevisoocytes

2000 • 40 citations

The role of transmembrane pH gradients in the lactic acid induced swelling of astrocytes

1990 • 40 citations

Intracellular cyclic AMP inhibits native and recombinant volume‐regulated chloride channels from mammalian heart

2000 • 40 citations

Inverse regulation of human ERBB2 and epidermal growth factor receptors by tumor necrosis factor alpha.

1993 • 39 citations

Volume-sensitive chloride channels in the primary culture cells of human cervical carcinoma

1996 • 39 citations

Predation risk and feeding in an intertidal predatory snail

1992 • 39 citations

Stretch-induced activation of Ca2+-permeable ion channels is involved in the volume regulation of hypotonically swollen epithelial cells

1990 • 39 citations

The role of swelling-induced anion channels during neuronal volume regulation

1996 • 39 citations

Osmosis and the Regulation of Cell Volume

1995 • 38 citations

Modulation of dog atrial swelling-induced chloride current by cAMP: protein kinase A-dependent and -independent pathways.

1997 • 36 citations

Osmotic stress induces both secretion and apoptosis in rat alveolar type II cells

1998 • 34 citations

Ca(2+)-mobilizing hormones potentiate hypotonicity-induced activation of ionic conductances in Intestine 407 cells

1994 • 33 citations

Synergetic activation of outwardly rectifying Cl⁻ currents by hypotonic stress and external Ca²⁺ in murine osteoclasts

1999 • 33 citations

IGF-1 Regulates Apoptosis of Cardiac Myocyte Induced by Osmotic-Stress

2000 • 33 citations

Pro‐ and anti‐apoptotic effects of K⁺ in HeLa cells

1998 • 32 citations

Ca²⁺‐sensing receptor‐mediated regulation of volume‐sensitive Cl⁻ channels in human epithelial cells

2000 • 29 citations

Protein phosphotyrosine phosphatase inhibitors suppress regulatory volume decrease and the volume-sensitive Cl - conductance in mouse fibroblasts

1999 • 29 citations

Leukotriene-D4 induced cell shrinkage in Ehrlich ascites tumor cells

1989 • 29 citations

Cl⁻and K⁺conductances activated by cell swelling in primary cultures of rabbit distal bright convoluted tubules

1997 • 28 citations

Separate K+ and Cl- transport pathways are activated for regulatory volume decrease in jejunal villus cells

1991 • 28 citations

Regulatory volume increase after hypertonicity- or vasoactive-intestinal-peptide-induced cell-volume decrease in small-intestinal crypts is dependent on Na+-K+-2Cl? cotransport

1993 • 26 citations

Leukotriene D4 activates a chloride conductance in hepatocytes from lipopolysaccharide-treated rats.

1997 • 25 citations

Pharmacology of volume regulation following hypotonicity-induced cell swelling in clonal N1E115 neuroblastoma cells

1995 • 24 citations

Inhibition of Na+, K+-ATPase activates swelling-induced taurine efflux in a human neuroblastoma cell line

1998 • 23 citations

Cell Volume-Sensitive Chloride Channels

1998 • 22 citations

Segmental differences along the crypt axis in the response of cell volume to secretagogues or hypotonic medium in the rat colon

1994 • 22 citations

Alanine uptake activates hepatocellular chloride channels

1997 • 21 citations

Regulation of a volume‐sensitive anion channel in rat pancreatic β‐cells by intracellular adenine nucleotides

1999 • 20 citations

Cardiac Swelling-Induced Chloride Current is Enhanced by Endothelin

2000 • 19 citations

Osmotic cell swelling-induced ATP release mediates the activationof extracellular signal-regulated protein kinase (Erk)-1/2 but not the activation of osmo-sensitive anion channels

1999 • 19 citations

Thrombin potentiates volume-activated chloride currents in pulmonary artery endothelial cells

1997 • 19 citations

Adaptation of cultured mammalian neurons to a hypotonic environment with age-related response

1989 • 17 citations

Differential Osmosensing Signalling Pathways and G-protein Involvement in Human Cervical Cells with Different Tumour Potential

1998 • 16 citations

Evidence for several mechanisms of volume regulation in neuroblastoma×glioma hybrid NG108-15 cells

1999 • 15 citations

Anoxia in vitro does not induce neuronal swelling or death

1996 • 14 citations

Hyposmotically activated chloride channels in cultured rabbit non‐pigmented ciliary epithelial cells

1999 • 13 citations

The Ionic Basis of the Hypo-Osmotic Depolarization in Neurons From the Opisthobranch Mollusc Elysia Chlorotica

1992 • 10 citations

The role of Ca²⁺ in volume regulation induced by Na⁺‐coupled alanine uptake in single proximal tubule cells isolated from frog kidney

1998 • 10 citations

Chloride channels in cultured human skeletal muscle are regulated by G proteins

1992 • 9 citations

Stimulation of Na⁺‐alanine cotransport activates a voltage‐dependent conductance in single proximal tubule cells isolated from frog kidney

1999 • 8 citations