Current concepts of brain edema

Excitotoxic cell death

1992 • 2,307 citations

Astrocytes induce blood–brain barrier properties in endothelial cells

1987 • 1,593 citations

The influence of potassium and chloride ions on the membrane potential of single muscle fibres

1959 • 1,458 citations

Effect of anoxia on ion distribution in the brain

1985 • 1,341 citations

Pathophysiology and treatment of focal cerebral ischemia

1992 • 1,287 citations

Presidential Address^*

1967 • 1,183 citations

Nonvesicular release of neurotransmitter

1993 • 837 citations

Oxygen radicals and the nervous system

1985 • 822 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures

1990 • 689 citations

Rodent models of cerebral ischemia.

1989 • 663 citations

Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms

1994 • 630 citations

Functional interactions between neurons and astrocytes I. Turnover and metabolism of putative amino acid transmitters

1979 • 622 citations

Regulation of cellular volume.

1977 • 607 citations

Responses of lymphocytes to anisotonic media: volume-regulating behavior

1984 • 427 citations

Ion Channels In Vertebrate Glia

1990 • 373 citations

Early Microvascular and Neuronal Consequences of Traumatic Brain Injury: A Light and Electron Microscopic Study in Rats

1994 • 357 citations

Calcium signaling in cell volume regulation

1992 • 349 citations

The Blood-Brain Barrier

1986 • 337 citations

Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat

1994 • 304 citations

Control of Brain Volume During Hyperosmolar and Hypoosmolar Conditions

1993 • 295 citations

Extracellular K+ accumulation in the central nervous system

1983 • 282 citations

Volume regulation in astrocytes: A role for taurine as an osmoeffector

1988 • 260 citations

Handbook of Neurochemistry

1983 • 249 citations

Molecular Anatomy of the Blood-Brain Barrier as Defined by Immunocytochemistry

1991 • 240 citations

Ca2+-dependent and Ca2+- independent glutamate release, energy status and cytosolic free Ca2+ concentration in isolated nerve terminals following metabolic inhibition: Possible relevance to hyoglycaemia and anoxia

1988 • 228 citations

Brain Hydroxyl Radical Generation in Acute Experimental Head Injury

1993 • 226 citations

Cell volume in the regulation of hepatic function: a mechanism for metabolic control

1991 • 225 citations

Head injury: Basic and clinical aspects

1983 • 216 citations

Experimental ischemic stroke: a review.

1984 • 213 citations

The experimental production of œdema in the central nervous system of the rat by triethyltin compounds

1957 • 202 citations

Direct Measurement of Hydroxyl Radicals, Lipid Peroxidation, and Blood–Brain Barrier Disruption Following Unilateral Cortical Impact Head Injury in the Rat

1994 • 195 citations

PHYSIOLOGICAL AND PATHOLOGICAL ASPECTS OF ASTROCYTIC SWELLING

1986 • 193 citations

Glutamate opens Na⁺/K⁺ channels in cultured astrocytes

1988 • 190 citations

Role of calcium in astrocyte volume regulation and in the release of ions and amino acids

1993 • 185 citations

Glial swelling following human cerebral contusion: an ultrastructural study.

1991 • 185 citations

Furosemide- and bumetanide-sensitive ion transport and volume control in primary astrocyte cultures from rat brain

1985 • 184 citations

The Neurobiology of central nervous system trauma

1994 • 173 citations

Astrocytic Swelling Due to Hypotonic or High K⁺Medium Causes Inhibition of Glutamate and Aspartate Uptake and Increases Their Release

1995 • 161 citations

Discrimination between different types of white matter edema with diffusion‐weighted MR imaging

1993 • 150 citations

Extracellular Glutamate During Focal Cerebral Ischaemia in Rats: Time Course and Calcium Dependency

1994 • 145 citations

SITS-inhibitable Cl- transport and Na+-dependent H+ production in primary astroglial cultures.

1979 • 145 citations

Cell swelling activates K+ and Cl? channels as well as nonselective, stretch-activated cation channels in ehrlich ascites tumor cells

1992 • 145 citations

Ca2+-Activated Cell Volume Recovery Mechanisms

1990 • 134 citations

Excitatory amino acid-stimulated uptake of 22Na+ in primary astrocyte cultures

1989 • 134 citations

Potassium and Taurine Release Are Highly Correlated with Regulatory Volume Decrease in Neonatal Primary Rat Astrocyte Cultures

1994 • 126 citations

Glutamate transporters from brain

1993 • 125 citations

Light- and electron-microscopic changes in central nervous tissue after electrophoretic injection of glutamate

1971 • 112 citations

Degeneration of astrocytes in feline retinopathy of prematurity causes failure of the blood-retinal barrier.

1992 • 109 citations

Induction of Blood‐Brain Barrier Characteristics in Bovine Brain Endothelial Cells by Rat Astroglial Cells in Transfilter Coculture^a

1991 • 102 citations

Characterization of Experimental Ischemic Brain Edema Utilizing Proton Nuclear Magnetic Resonance Imaging

1986 • 102 citations

Ultrastructural analysis of kainic acid lesion to cerebellar cortex

1980 • 101 citations

Complete cerebral ischemia

1979 • 97 citations

Regulation of taurine transport in Ehrlich ascites tumor cells

1993 • 94 citations

Cellular and subcellular redistribution of glutamate-, glutamine- and taurine-like immunoreactivities during forebrain ischemia: A semiquantitative electron microscopic study in rat hippocampus

1991 • 86 citations

Single‐channel characteristics of the large‐conductance anion channel in rat cortical astrocytes in primary culture

1993 • 85 citations

Ultrastructural features of a brain injury model in cat

1988 • 78 citations

Electrical impedance tomography (EIT) of brain function

1992 • 71 citations

Origin of Ischemia‐Induced Glutamate Efflux in the CA1 Field of the Gerbil Hippocampus: An In Vivo Brain Microdialysis Study

1994 • 71 citations

The Physiology of the Blood-Brain Barrier

1990 • 66 citations

Cerebral Edema in Water Intoxication

1968 • 64 citations

Molecular mechanisms of glial swelling in vitro

1988 • 62 citations

Volume regulation during recovery from chronic hypertonicity in brain glial cells

1992 • 62 citations

Agents for the treatment of brain edema. 2. [(2,3,9,9a-Tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]alkanoic acids and some of their analogs

1986 • 61 citations

Early Evolution and Recovery from Excitotoxic Injury in the Neonatal Rat Brain: A Study Combining Magnetic Resonance Imaging, Electrical Impedance, and Histology

1994 • 52 citations

Mechanism of rapid K+-induced swelling of mouse astrocytes

1992 • 51 citations

Swelling and ion uptake in cat cerebrocortical slices:

1983 • 49 citations

Morphological and chemical studies in cerebral edema: Triethyl tin-induced edema

1965 • 45 citations

Effect of an extract of Ginkgo biloba on triethyltin-induced cerebral edema

1986 • 45 citations

Counter‐transport of potassium by the glutamate uptake carrier in glial cells isolated from the tiger salamander retina.

1994 • 44 citations

Regulation of Brain Volume Under Isosmotic and Anisosmotic Conditions

1991 • 43 citations

Role of eicosanoids, inositol phosphates and extracellular Ca²⁺ in cell‐volume regulation of rat liver

1991 • 41 citations

Behavioral Endpoint Measures for Preclinical Trials Using Experimental Models of Spinal Cord Injury

1992 • 40 citations

Ethacrynic Acid and Related Diuretics: Relationship of Structure to Beneficial and Detrimental Actions

1981 • 37 citations

Brain water content, brain blood volume, blood chemistry, and pathology in a model of cerebral edema

1990 • 34 citations

Improved Recovery from a Traumatic-Hypoxic Brain Injury in Cats by Intracisternal Injection of an Anion Transport Inhibitor

1987 • 33 citations

Morphologic evidence of a primary response of glia to kainic acid administration into the rat neostriatum; Studied in vivo and in vitro

1986 • 33 citations

Swelling of the Müller fibers in the chicken retina

1982 • 32 citations

Reduction in ischemic brain injury in rabbits by the anion transport inhibitor L-644,711.

1992 • 29 citations

The potassium-dependence of excitatory amino acid transport: resolution of a paradox

1991 • 29 citations

Drugs for the treatment of traumatic brain injury

1987 • 28 citations

Brain Tissue Electrolytes.

1967 • 27 citations

Chloride Transport across Glial Membranes

1990 • 23 citations