TRPV4 calcium entry channel: a paradigm for gating diversity

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1997 • 8,634 citations

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

1998 • 6,595 citations

Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor

2000 • 3,436 citations

The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli

1998 • 3,026 citations

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

1999 • 2,128 citations

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1996 • 2,079 citations

Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution

2001 • 2,033 citations

Vanilloid (Capsaicin) receptors and mechanisms.

1999 • 1,825 citations

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

1994 • 1,564 citations

A capsaicin-receptor homologue with a high threshold for noxious heat

1999 • 1,547 citations

Role of Endogenous Cannabinoids in Synaptic Signaling

2003 • 1,535 citations

Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor

2000 • 1,348 citations

P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function

2002 • 1,286 citations

Endocannabinoid Signaling in the Brain

2002 • 1,240 citations

The trp ion channel family

2001 • 1,108 citations

Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances

2000 • 1,048 citations

Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels

2003 • 983 citations

OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity

2000 • 982 citations

Heat-Evoked Activation of the Ion Channel, TRPV4

2002 • 966 citations

A Heat-Sensitive TRP Channel Expressed in Keratinocytes

2002 • 913 citations

Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers

2002 • 871 citations

TRPV3 is a calcium-permeable temperature-sensitive cation channel

2002 • 870 citations

The TRP Channels, a Remarkably Functional Family

2002 • 822 citations

Induction of vanilloid receptor channel activity by protein kinase C

2000 • 814 citations

TRPV3 is a temperature-sensitive vanilloid receptor-like protein

2002 • 811 citations

LTRPC2 Ca2+-Permeable Channel Activated by Changes in Redox Status Confers Susceptibility to Cell Death

2002 • 794 citations

The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)

2000 • 766 citations

Impaired Pressure Sensation in Mice Lacking TRPV4

2003 • 715 citations

Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action

1998 • 708 citations

Nitric oxide and neurally mediated regulation of skin blood flow during local heating

2001 • 676 citations

Heat-evoked Activation of TRPV4 Channels in a HEK293 Cell Expression System and in Native Mouse Aorta Endothelial Cells

2002 • 659 citations

A mammalian two pore domain mechano-gated S-like K+ channel

1998 • 627 citations

Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4

2003 • 626 citations

OSM-9, A Novel Protein with Structural Similarity to Channels, Is Required for Olfaction, Mechanosensation, and Olfactory Adaptation inCaenorhabditis elegans

1997 • 621 citations

Molecular Cloning and Characterization of a Channel-like Transporter Mediating Intestinal Calcium Absorption

1999 • 610 citations

Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors

1999 • 599 citations

Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives

2002 • 595 citations

Molecular Identification of the Apical Ca2+Channel in 1,25-Dihydroxyvitamin D3-responsive Epithelia

1999 • 587 citations

Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro.

1989 • 569 citations

Role of the Preoptic-Anterior Hypothalamus in Thermoregulation and Fever

2000 • 526 citations

A Modular PIP ₂ Binding Site as a Determinant of Capsaicin Receptor Sensitivity

2003 • 521 citations

Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide

2001 • 493 citations

The diversity in the vanilloid (TRPV) receptor family of ion channels

2002 • 485 citations

Ion Channels and Synaptic Organization

2000 • 475 citations

Combinatorial Expression of TRPV Channel Proteins Defines Their Sensory Functions and Subcellular Localization in C. elegans Neurons

2002 • 455 citations

Hypotonicity Induces TRPV4-Mediated Nociception in Rat

2003 • 428 citations

A TRPV family ion channel required for hearing in Drosophila

2003 • 419 citations

Endocannabinoids

1998 • 416 citations

Cytochrome P450 and Vascular Homeostasis

2001 • 379 citations

Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels

2001 • 375 citations

Impaired osmotic sensation in mice lacking TRPV4

2003 • 368 citations

Impairment of Store-Operated Ca ²⁺ Entry in TRPC4 ^−/− Mice Interferes With Increase in Lung Microvascular Permeability

2002 • 363 citations

Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6

2003 • 332 citations

Permeation and Gating Properties of the Novel Epithelial Ca2+ Channel

2000 • 318 citations

Molecular Determinants of Permeation through the Cation Channel TRPV4

2002 • 313 citations

Temperature-modulated Diversity of TRPV4 Channel Gating

2003 • 310 citations

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1

2000 • 305 citations

Trp12, a novel Trp related protein from kidney

2000 • 303 citations

Warm Temperatures Activate TRPV4 in Mouse 308 Keratinocytes

2003 • 293 citations

OSMORECEPTORS IN THE CENTRAL NERVOUS SYSTEM

1997 • 289 citations

Mesenteric Vasodilation Mediated by Endothelial Anandamide Receptors

1999 • 255 citations

Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2

2001 • 252 citations

CaT1 and the Calcium Release-activated Calcium Channel Manifest Distinct Pore Properties

2001 • 236 citations

Predicting adaptive evolution

2001 • 229 citations

Novel “Nonkinase” Phorbol Ester Receptors: The C1 Domain Connection

2002 • 224 citations

Ca2+-dependent Potentiation of the Nonselective Cation Channel TRPV4 Is Mediated by a C-terminal Calmodulin Binding Site

2003 • 223 citations

Human Calcium Transport Protein CaT1

2000 • 209 citations

Regulation of a Transient Receptor Potential (TRP) Channel by Tyrosine Phosphorylation

2003 • 197 citations

Anandamide Uptake by Human Endothelial Cells and Its Regulation by Nitric Oxide

2000 • 189 citations

Identification of an Aspartic Residue in the P-loop of the Vanilloid Receptor That Modulates Pore Properties

2000 • 180 citations

Transient Receptor Potential Channels in Endothelium: Solving the Calcium Entry Puzzle?

2003 • 179 citations

THE MOLECULES OF MECHANOSENSATION

1997 • 174 citations

The Single Pore Residue Asp542 Determines Ca2+ Permeation and Mg2+ Block of the Epithelial Ca2+ Channel

2001 • 172 citations

Competitive regulation of CaT-like-mediated Ca ²⁺ entry by protein kinase C and calmodulin

2001 • 165 citations

Agonist Recognition Sites in the Cytosolic Tails of Vanilloid Receptor 1

2002 • 164 citations

A Rat Kidney-specific Calcium Transporter in the Distal Nephron

2000 • 158 citations

Mg2+-dependent Gating and Strong Inward Rectification of the Cation Channel TRPV6

2003 • 155 citations

Vanilloid and TRP channels: a family of lipid-gated cation channels

2002 • 149 citations

Differential activation of the volume-sensitive cation channel TRP12 (OTRPC4) and volume-regulated anion currents in HEK-293 cells

2001 • 138 citations

Endocannabinoids: a new class of vasoactive substances

1998 • 128 citations

Modulation of TRPV4 gating by intra- and extracellular Ca2+

2003 • 124 citations

Protein Kinase Cα Is Required for Vanilloid Receptor 1 Activation

2002 • 116 citations

Cardiovascular actions of cannabinoids and their generation during shock

1998 • 112 citations

Vertebrate and invertebrate TRPV-like mechanoreceptors

2003 • 109 citations

Maxi K⁺ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line

2002 • 108 citations

Structural Conservation of the Genes Encoding CaT1, CaT2, and Related Cation Channels

2001 • 105 citations

Fast and Slow Inactivation Kinetics of the Ca2+Channels ECaC1 and ECaC2 (TRPV5 and TRPV6)

2002 • 100 citations

Cardiovascular Effects of 2-Arachidonoyl Glycerol in Anesthetized Mice

2000 • 96 citations

Anandamide induces cough in conscious guinea‐pigs through VR1 receptors

2002 • 80 citations

Pore properties and ionic block of the rabbit epithelial calcium channel expressed in HEK 293 cells

2001 • 79 citations

Swelling-Induced Arachidonic Acid Release via the 85-kDa cPLA₂in Human Neuroblastoma Cells

1998 • 79 citations

Endocannabinoid hydrolases

2002 • 77 citations

Characterization of vasorelaxant responses to anandamide in the rat mesenteric arterial bed

2002 • 70 citations

Anandamide – the other side of the coin

2000 • 68 citations

Hypotonic cell swelling induces translocation of the α isoform of cytosolic phospholipase A₂ but not the γ isoform in Ehrlich ascites tumor cells

2000 • 67 citations

Anandamide‐induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels

2001 • 66 citations

Resiniferatoxin‐type phorboid vanilloids display capsaicin‐like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1

1999 • 64 citations

Modulation of the epithelial Ca 2+ channel ECaC by extracellular pH

2001 • 60 citations

DFNA25, a Novel Locus for Dominant Nonsyndromic Hereditary Hearing Impairment, Maps to 12q21-24

2001 • 60 citations

The ligand that came from within

2001 • 56 citations

Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat

2003 • 53 citations

Anandamide and endothelium-derived hyperpolarizing factor act via a common vasorelaxant mechanism in rat mesentery

1998 • 51 citations

Warming-activated channels of warm-sensitive neurons in rat hypothalamic slices

1999 • 45 citations

A family of calcium-permeable channels in the kidney: distinct roles in renal calcium handling

2002 • 35 citations

In vitro thermosensitivity of the midline thalamus

1995 • 29 citations

Primary cold-sensitive neurons in acutely dissociated cells of rat hypothalamus

2003 • 13 citations