Cell Volume-Sensitive Chloride Channels: Phenotypic Properties and Molecular Identity

Functional Significance of Cell Volume Regulatory Mechanisms

1998 • 1,871 citations

Molecular Structure and Physiological Function of Chloride Channels

2002 • 1,234 citations

Membrane mechanisms in volume and pH regulation in vertebrate cells

1989 • 880 citations

Volume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor

1997 • 652 citations

Cellular and molecular physiology of volume-sensitive anion channels

1996 • 620 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Receptor‐mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD)

2001 • 523 citations

Disruption of ClC-3, a Chloride Channel Expressed on Synaptic Vesicles, Leads to a Loss of the Hippocampus

2001 • 501 citations

Molecular identification of a volume-regulated chloride channel

1997 • 443 citations

Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume

1992 • 424 citations

Cell volume regulation: osmolytes, osmolyte transport, and signal transduction

2003 • 362 citations

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1992 • 328 citations

New mammalian chloride channel identified by expression cloning

1992 • 323 citations

Macula densa cell signaling involves ATP release through a maxi anion channel

2003 • 274 citations

The sulfonylurea receptor

1992 • 257 citations

Volume-sensitive Chloride Channels Involved in Apoptotic Volume Decrease and Cell Death

2006 • 225 citations

A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl^-channel

2004 • 223 citations

Ca2+ sensitivity of volume‐regulatory K+ and Cl‐ channels in cultured human epithelial cells.

1988 • 223 citations

Cloning and expression of a protein kinase C-regulated chloride channel abundantly expressed in rat brain neuronal cells

1994 • 223 citations

Volume-Dependent Atp-Conductive Large-Conductance Anion Channel as a Pathway for Swelling-Induced Atp Release

2001 • 212 citations

Chloride channels activated by osmotic stress in T lymphocytes.

1993 • 204 citations

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.

1995 • 191 citations

Activation of a Cl- current by hypotonic volume increase in human endothelial cells.

1994 • 187 citations

Volume‐regulatory Cl‐ channel currents in cultured human epithelial cells.

1992 • 185 citations

Tamoxifen blocks chloride channels. A possible mechanism for cataract formation.

1994 • 165 citations

ATP release via anion channels

2005 • 165 citations

The Tyrosine Kinase p56lck Mediates Activation of Swelling-induced Chloride Channels in Lymphocytes

1998 • 161 citations

The volume-sensitive organic osmolyte-anion channel VSOAC is regulated by nonhydrolytic ATP binding

1994 • 156 citations

NAD(P)H Oxidase-derived H2O2 Signals Chloride Channel Activation in Cell Volume Regulation and Cell Proliferation

2004 • 145 citations

Volume‐sensitive chloride conductance in bovine chromaffin cell membrane.

1992 • 141 citations

Reduced intracellular ionic strength as the initial trigger for activation of endothelial volume-regulated anion channels

1999 • 140 citations

Blockers of volume-activated Cl? currents inhibit endothelial cell proliferation

1995 • 134 citations

Swelling-activated and isoprenaline-activated chloride currents in guinea pig cardiac myocytes have distinct electrophysiology and pharmacology.

1994 • 133 citations

Ion Channels and Transporters Involved in Cell Volume Regulation and Sensor Mechanisms

2004 • 131 citations

Role of ATP‐conductive anion channel in ATP release from neonatal rat cardiomyocytes in ischaemic or hypoxic conditions

2004 • 130 citations

Blocking swelling‐activated chloride current inhibits mouse liver cell proliferation

2001 • 129 citations

Volume-activated chloride channels in HeLa cells are blocked by verapamil and dideoxyforskolin

1993 • 126 citations

Activation of volume‐regulated chloride currents by reduction of intracellular ionic strength in bovine endothelial cells

1998 • 119 citations

Characterization of the voltage-dependent properties of a volume-sensitive anion conductance.

1995 • 118 citations

Dual roles of plasmalemmal chloride channels in induction of cell death

2004 • 115 citations

Stretch of β1 Integrin Activates an Outwardly Rectifying Chloride Current via FAK and Src in Rabbit Ventricular Myocytes

2003 • 113 citations

An ATP-Sensitive Cl− Channel Current That Is Activated by Cell Swelling, cAMP, and Glyburide in Insulin-Secreting Cells

1995 • 113 citations

Intracellular ionic strength regulates the volume sensitivity of a swelling-activated anion channel

1998 • 112 citations

Inhibitory Effects of Glibenclamide on Cystic Fibrosis Transmembrane Regulator, Swelling-Activated, and Ca ²⁺ -Activated Cl ⁻ Channels in Mammalian Cardiac Myocytes

1997 • 95 citations

Secretion and cell volume regulation by salivary acinar cells from mice lacking expression of the Clcn3 Cl⁻ channel gene

2002 • 94 citations

A volume-activated anion conductance in insulin-secreting cells

1996 • 94 citations

Antisense oligonucleotides suppress cell-volume-induced activation of chloride channels

1995 • 93 citations

Expression of Human pICln and ClC-6 in Xenopus Oocytes Induces an Identical Endogenous Chloride Conductance

1997 • 88 citations

Cell swelling activates ATP-dependent voltage-gated chloride channels in M-1 mouse cortical collecting duct cells.

1996 • 88 citations

P‐glycoprotein regulates a volume‐activated chloride current in bovine non‐pigmented ciliary epithelial cells.

1996 • 87 citations

Stable and functional expression of the CIC-3 chloride channel in somatic cell lines

1995 • 81 citations

Cl? channel inhibition by glibenclamide is not specific for the CFTR-type Cl? channel

1995 • 80 citations

Single-channel properties of a volume-sensitive anion conductance. Current activation occurs by abrupt switching of closed channels to an open state.

1995 • 78 citations

Functional and molecular characterization of a volume‐sensitive chloride current in rat brain endothelial cells

1999 • 78 citations

Chloride Channel Inhibition Prevents ROSdependentApoptosis Induced by Ischemia-Reperfusion in Mouse Cardiomyocytes

2005 • 76 citations

Contribution of a swelling-activated chloride current to changes in the cardiac action potential

1997 • 74 citations

Involvement of Stretch-Activated Cl⁻Channels in Ramification of Murine Microglia

1998 • 73 citations

Disruption of Mitochondrial Respiration Inhibits Volume-Regulated Anion Channels and Provokes Neuronal Cell Swelling

1998 • 72 citations

ClC-3-independent, PKC-dependent Activity of Volume-sensitive Cl<sup>-</sup> Channel in Mouse Ventricular Cardiomyocytes

2004 • 70 citations

Glibenclamide blocks volume-sensitive Cl⁻ channels by dual mechanisms

1998 • 69 citations

The chloride current induced by expression of the protein pICln in Xenopus oocytes differs from the endogenous volume‐sensitive chloride current.

1996 • 67 citations

Volume-sensitive chloride current in pigmented ciliary epithelial cells: role of phospholipases

1997 • 65 citations

Volume-sensitive chloride channels associated with human cervical carcinogenesis.

1995 • 65 citations

Characterization of ion channels seen in subconfluent human dermal fibroblasts.

1991 • 63 citations

Downregulation of volume-activated Cl- currents during muscle differentiation

1997 • 61 citations

Volume-activated chloride currents in pancreatic duct cells

1995 • 60 citations

Volume-Regulatory Ion Channels in Epithelial Cells

1989 • 59 citations

ATP-Conducting Maxi-Anion Channel: A New Player in Stress-Sensory Transduction

2004 • 59 citations

Hypotonically activated chloride current in HSG cells

1994 • 56 citations

Roles of Volume-sensitive Cl− Channel in Cisplatin-induced Apoptosis in Human Epidermoid Cancer Cells

2005 • 55 citations

Sensitivity of volume-sensitive Cl- conductance in human epithelial cells to extracellular nucleotides

1996 • 54 citations

Glucose and a-ketoisocaproate induce transient inward currents in rat pancreatic beta cells

1997 • 54 citations

Volume-sensitive Chloride Channel Activity Does Not Depend on Endogenous P-glycoprotein

1995 • 49 citations

The volume-activated chloride current in human endothelial cells depends on intracellular ATP

1994 • 48 citations

Mg2+ and ATP-dependence of volume-sensitive Cl- channels in human epithelial cells.

1994 • 45 citations

Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line.

2002 • 45 citations

Swelling‐ and cAMP‐Activated Cl⁻ Currents in Isolated Rat Carotid Body Type I Cells

1997 • 44 citations

Disopyramide blocks pancreatic ATP-sensitive K+ channels and enhances insulin release

1993 • 43 citations

Volume-sensitive chloride channels in the primary culture cells of human cervical carcinoma

1996 • 39 citations

Swelling‐induced Cl⁻ current in guinea‐pig atrial myocytes: inhibition by glibenclamide

1997 • 39 citations

Recombinant pICln Forms Highly Cation-selective Channels when Reconstituted into Artificial and Biological Membranes

1998 • 38 citations

Functional reconstitution of ICln in lipid bilayers

2000 • 36 citations

Protein kinase C-independent correlation between P-glycoprotein expression and volume sensitivity of Cl− channel

1997 • 36 citations

cAMP-activated Cl- channels in primary cultures of spiny dogfish (Squalus acanthias) rectal gland

1995 • 33 citations

Hypotonic activation of volume-sensitive outwardly rectifying chloride channels in cultured PASMCs is modulated by SGK

2004 • 33 citations

Ca²⁺‐sensing receptor‐mediated regulation of volume‐sensitive Cl⁻ channels in human epithelial cells

2000 • 29 citations

Single-Channel Properties of Volume-Sensitive Cl− Channel in ClC-3–Deficient Cardiomyocytes

2005 • 28 citations

Cl⁻and K⁺conductances activated by cell swelling in primary cultures of rabbit distal bright convoluted tubules

1997 • 28 citations

Recovery from lactacidosis‐induced glial cell swelling with the aid of exogenous anion channels

2003 • 27 citations

The Swelling-Activated Anion Conductance in the Mouse Renal Inner Medullary Collecting Duct Cell Line mIMCD-K2

2000 • 22 citations

Volume Expansion Sensitivity of Swelling-Activated Cl- Channel in Human Epithelial Cells.

2000 • 22 citations

Alanine uptake activates hepatocellular chloride channels

1997 • 21 citations

ICln channels reconstituted in heart-lipid bilayer are selective to chloride

2002 • 18 citations