Thrombin potently enhances swelling‐sensitive glutamate efflux from cultured astrocytes

Thrombin signalling and protease-activated receptors

2000 • 2,383 citations

Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury

2006 • 453 citations

Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway

1996 • 372 citations

The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective?

2002 • 350 citations

The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

2000 • 287 citations

Cellular and Molecular Pathways of Ischemic Neuronal Death

2002 • 263 citations

Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy

2005 • 257 citations

Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ

2002 • 237 citations

Potentiation of NMDA Receptor Function by the Serine Protease Thrombin

2000 • 225 citations

The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia

2003 • 200 citations

Four different types of protease‐activated receptors are widely expressed in the brain and are up‐regulated in hippocampus by severe ischemia

2001 • 196 citations

DCPIB is a novel selective blocker of I_Cl,swell and prevents swelling‐induced shortening of guinea‐pig atrial action potential duration

2001 • 176 citations

Four subtypes of protease‐activated receptors, co‐expressed in rat astrocytes, evoke different physiological signaling

2001 • 175 citations

Thrombin accumulation in brains of patients with Alzheimer's disease

1992 • 172 citations

Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes

2004 • 149 citations

Pharmacological comparison of swelling‐activated excitatory amino acid release and Cl⁻ currents in cultured rat astrocytes

2006 • 123 citations

Up-Regulation of Proteinase-Activated Receptor 1 Expression in Astrocytes During HIV Encephalitis

2003 • 120 citations

Volume-Regulated Anion Channels Are the Predominant Contributors to Release of Excitatory Amino Acids in the Ischemic Cortical Penumbra

2004 • 115 citations

ATP regulates anion channel-mediated organic osmolyte release from cultured rat astrocytes via multiple Ca²⁺-sensitive mechanisms

2004 • 111 citations

Influence of Calcium on Regulatory Volume Decrease: Role of Potassium Channels

2000 • 92 citations

Thrombin Attenuates Neuronal Cell Death and Modulates Astrocyte Reactivity Induced by β‐Amyloid In Vitro

1996 • 83 citations

Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo

2006 • 80 citations

Intracerebral Hirudin Injection Attenuates Ischemic Damage and Neurologic Deficits without Altering Local Cerebral Blood Flow

2004 • 67 citations

Effects of a thrombin inhibitor, argatroban, on ischemic brain damage in the rat distal middle cerebral artery occlusion model.

1996 • 40 citations

Thrombin in ischemic neuronal death

2006 • 40 citations

Activation of muscarinic cholinergic receptors enhances the volume‐sensitive efflux of myo‐inositol from SH‐SY5Y neuroblastoma cells

2003 • 37 citations

Potentiation of the osmosensitive taurine release and cell volume regulation by cytosolic Ca²⁺ rise in cultured cerebellar astrocytes

2003 • 36 citations

Subnanomolar Concentrations of Thrombin Enhance the Volume-Sensitive Efflux of Taurine from Human 1321N1 Astrocytoma Cells

2005 • 26 citations

Hypotonicity and Thrombin Activate Taurine Efflux in BC3H1 and C2C12Myoblasts That Is Down Regulated during Differentiation

1997 • 26 citations

Unraveling thrombin's true microglia‐activating potential: markedly disparate profiles of pharmaceutical‐grade and commercial‐grade thrombin preparations

2005 • 24 citations

Regulation of Volume-Sensitive Osmolyte Efflux from Human SH-SY5Y Neuroblastoma Cells following Activation of Lysophospholipid Receptors

2006 • 24 citations

Potentiation of the Osmosensitive Release of Taurine and d-Aspartate from SH-SY5Y Neuroblastoma Cells after Activation of M₃Muscarinic Cholinergic Receptors

2004 • 22 citations

Mechanisms of the ATP potentiation of hyposmotic taurine release in Swiss 3T3 fibroblasts

2004 • 17 citations

The Osmolality-Sensitive Taurine Channel in Flounder Erythrocytes is Strongly Stimulated by Noradrenaline Under Hypo-Osmotic Conditions

1995 • 11 citations