Amazing chloride channels: an overview

X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity

2002 • 1,571 citations

Molecular Structure and Physiological Function of Chloride Channels

2002 • 1,234 citations

Structure and Function of the CFTR Chloride Channel

1999 • 977 citations

Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man

2001 • 968 citations

Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III

1997 • 847 citations

Neuronal KCNQ potassium channels:physislogy and role in disease

2000 • 809 citations

Volume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor

1997 • 652 citations

CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP

1995 • 647 citations

Cellular and molecular physiology of volume-sensitive anion channels

1996 • 620 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Barttin is a Cl- channel β-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion

2001 • 545 citations

Claudins create charge-selective channels in the paracellular pathway between epithelial cells

2002 • 530 citations

ClC-5 Cl--channel disruption impairs endocytosis in a mouse model for Dent's disease

2000 • 524 citations

Receptor‐mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD)

2001 • 523 citations

Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure

2001 • 506 citations

Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes

1990 • 505 citations

Disruption of ClC-3, a Chloride Channel Expressed on Synaptic Vesicles, Leads to a Loss of the Hippocampus

2001 • 501 citations

A constitutively open potassium channel formed by KCNQ1 and KCNE3

2000 • 481 citations

The vitelliform macular dystrophy protein defines a new family of chloride channels

2002 • 463 citations

Regulation of Cell Volume in Health and Disease

1995 • 450 citations

Molecular identification of a volume-regulated chloride channel

1997 • 443 citations

Control of CFTR Channel Gating by Phosphorylation and Nucleotide Hydrolysis

1999 • 437 citations

CFTR Is a Conductance Regulator as well as a Chloride Channel

1999 • 436 citations

Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion

1995 • 360 citations

Properties of volume-regulated anion channels in mammalian cells

1997 • 357 citations

New mammalian chloride channel identified by expression cloning

1992 • 323 citations

The CLC chloride channel family

1999 • 321 citations

Male germ cells and photoreceptors, both dependent on close cell–cell interactions, degenerate upon ClC-2 Cl− channel disruption

2001 • 315 citations

Accessory Protein Facilitated CFTR-CFTR Interaction, a Molecular Mechanism to Potentiate the Chloride Channel Activity

2000 • 306 citations

Pharmacology of CFTR Chloride Channel Activity

1999 • 285 citations

Two physically distinct pores in the dimeric CIC-0 chloride channel

1996 • 281 citations

Cloning and Functional Expression of Rat CLC-5, a Chloride Channel Related to Kidney Disease

1995 • 279 citations

Muscle chloride channels.

1987 • 257 citations

Molecular dissection of gating in the ClC-2 chloride channel

1997 • 256 citations

Homodimeric architecture of a CIC-type chloride ion channel

1996 • 255 citations

Membrane changes in cells from myotonia patients.

1985 • 247 citations

Genomic Cloning, Molecular Characterization, and Functional Analysis of Human CLCA1, the First Human Member of the Family of Ca2+-Activated Cl−Channel Proteins

1998 • 245 citations

Mutational Analysis Demonstrates That ClC-4 and ClC-5 Directly Mediate Plasma Membrane Currents

1999 • 242 citations

Neuronal Ca2+-activated Cl− channels — homing in on an elusive channel species

2000 • 229 citations

Properties of voltage‐gated chloride channels of the ClC gene family.

1995 • 219 citations

Anion Transport in Heart

2000 • 215 citations

Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction

2001 • 212 citations

Volume-Dependent Atp-Conductive Large-Conductance Anion Channel as a Pathway for Swelling-Induced Atp Release

2001 • 212 citations

Cloning of an Epithelial Chloride Channel from Bovine Trachea

1995 • 209 citations

Chloride channels: An emerging molecular picture

1997 • 192 citations

Apoptosis, cell volume regulation and volume-regulatory chloride channels

2001 • 189 citations

Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

1995 • 188 citations

A Decade of CLC Chloride Channels: Structure, Mechanism, and Many Unsettled Questions

2000 • 179 citations

DCPIB is a novel selective blocker of I_Cl,swell and prevents swelling‐induced shortening of guinea‐pig atrial action potential duration

2001 • 176 citations

Bimodal Control of a Ca2+-Activated Cl− Channel by Different Ca2+ Signals

1999 • 174 citations

Barttin increases surface expression and changes current properties of ClC-K channels

2002 • 166 citations

Anion Permeation in Ca2+-Activated Cl− Channels

2000 • 163 citations

Volume-activated Cl− channels

1996 • 163 citations

The Tyrosine Kinase p56lck Mediates Activation of Swelling-induced Chloride Channels in Lymphocytes

1998 • 161 citations

Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland

1999 • 159 citations

Swelling-activated Organic Osmolyte Channels

1997 • 155 citations

Activation of calcium-dependent chloride channels in rat parotid acinar cells.

1996 • 154 citations

Swelling-activated organic osmolyte efflux: A new role for anion channels

1995 • 153 citations

Volume-regulated Anion Channels Serve as an Auto/Paracrine Nucleotide Release Pathway in Aortic Endothelial Cells

2002 • 152 citations

Regulation of Human CLC-3 Channels by Multifunctional Ca2+/Calmodulin-dependent Protein Kinase

2001 • 151 citations

Calcium‐activated chloride channels in bovine pulmonary artery endothelial cells.

1997 • 146 citations

Pores Formed by Single Subunits in Mixed Dimers of Different CLC Chloride Channels

2001 • 144 citations

Inhibition of epithelial Na⁺currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator

1997 • 142 citations

Molecular and Functional Characterization of a Calcium-sensitive Chloride Channel from Mouse Lung

1998 • 142 citations

Reduced intracellular ionic strength as the initial trigger for activation of endothelial volume-regulated anion channels

1999 • 140 citations

Role of Rho and Rho kinase in the activation of volume‐regulated anion channels in bovine endothelial cells

1999 • 140 citations

Chloride channels: a molecular perspective

1996 • 137 citations

CFTR: Mechanism of Anion Conduction

1999 • 136 citations

An Internalization Signal in ClC-5, an Endosomal Cl−Channel Mutated in Dent's Disease

2001 • 135 citations

Biophysical Properties of ClC-3 Differentiate It from Swelling-activated Chloride Channels in Chinese Hamster Ovary-K1 Cells

2000 • 134 citations

Ion channels in secretory granules of the pancreas and their role in exocytosis and release of secretory proteins

2002 • 133 citations

The Breast Cancer β4 Integrin and Endothelial Human CLCA2 Mediate Lung Metastasis

2001 • 132 citations

Temperature Dependence of Fast and Slow Gating Relaxations of ClC-0 Chloride Channels

1997 • 132 citations

Blocking swelling‐activated chloride current inhibits mouse liver cell proliferation

2001 • 129 citations

Projection structure of a ClC-type chloride channel at 6.5 Å resolution

2001 • 123 citations

CFTR: Interacting With Everything?

2001 • 122 citations

Inositol 3,4,5,6-Tetrakisphosphate Inhibits the Calmodulin-dependent Protein Kinase II-activated Chloride Conductance in T84 Colonic Epithelial Cells

1996 • 120 citations

Activation of volume‐regulated chloride currents by reduction of intracellular ionic strength in bovine endothelial cells

1998 • 119 citations

The Cystic Fibrosis Transmembrane Conductance Regulator Activates Aquaporin 3 in Airway Epithelial Cells

1999 • 119 citations

Molecular and functional aspects of anionic channels activated during regulatory volume decrease in mammalian cells*

2002 • 114 citations

CFTR, A Regulator of Channels

1999 • 111 citations

Divalent cation transport by the distal nephron: insights from Bartter's and Gitelman's syndromes

2000 • 110 citations

Permeation Through the Cftr Chloride Channel

2000 • 108 citations

Fast and Slow Gating Relaxations in the Muscle Chloride Channel Clc-1

2000 • 106 citations

Molecular Characteristics And Functional Diversity Of Clca Family Members

2000 • 104 citations

Ion permeation and selectivity in ClC-type chloride channels

2001 • 103 citations

Human ClC-3 Is Not the Swelling-activated Chloride Channel Involved in Cell Volume Regulation

2001 • 101 citations

A biologic function for an "orphan" messenger: D-myo-inositol 3,4,5,6-tetrakisphosphate selectively blocks epithelial calcium-activated chloride channels.

1996 • 99 citations

Ca 2+ -activated Cl - channels: a newly emerging anion transport family

2001 • 99 citations

Cloning and Characterization of Lung-Endothelial Cell Adhesion Molecule-1 Suggest It Is an Endothelial Chloride Channel

1997 • 99 citations

Reconstitution of Functional Voltage-gated Chloride Channels from Complementary Fragments of CLC-1

1997 • 98 citations

Molecular Determinants of Anion Selectivity in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore

2000 • 96 citations

Intracellular Ca²⁺ and Cl^– Channel Activation in Secretory Cells

2000 • 96 citations

Tumorigenicity of human breast cancer is associated with loss of the Ca2+-activated chloride channel CLCA2.

1999 • 96 citations

pICln Inhibits snRNP Biogenesis by Binding Core Spliceosomal Proteins

1999 • 95 citations

TiPS Receptor Nomenclature Supplement 1993

1993 • 94 citations

Tumor Suppression by a Proapoptotic Calcium-activated Chloride Channel in Mammary Epithelium

2001 • 94 citations

The cystic fibrosis transmembrane conductance regulator and its function in epithelial transport

1999 • 94 citations

ClC‐3B, a novel ClC‐3 splicing variant that interacts with EBP50 and facilitates expression of CFTR‐regulated ORCC

2002 • 93 citations

Elimination of the Slow Gating of Clc-0 Chloride Channel by a Point Mutation

1999 • 92 citations

Perspective: Molecular Identity of the Outwardly Rectifying, Swelling-activated Anion Channel: Time to Reevaluate pICln

1998 • 90 citations

Caveolin‐1 modulates the activity of the volume‐regulated chloride channel

1999 • 89 citations

Mechanosensitive Ca2+ transients in endothelial cells from human umbilical vein.

1994 • 89 citations

The multidrug resistance P-glycoprotein modulates cell regulatory volume decrease.

1996 • 89 citations

CFTR is required for cAMP inhibition of intestinal Na+ absorption in a cystic fibrosis mouse model

1996 • 87 citations

Regulation of the CFTR channel by phosphorylation

2001 • 81 citations

Evidence That Outwardly Rectifying Cl ⁻ Channels Underlie Volume-Regulated Cl ⁻ Currents in Heart

1997 • 77 citations

Association of ClC-3 Channel with Cl − Transport by Human Nonpigmented Ciliary Epithelial Cells

1996 • 77 citations

Mechanical stress-induced Ca²⁺entry and Cl⁻current in cultured human aortic endothelial cells

1999 • 76 citations

Annexin II Modulates Volume-activated Chloride Currents in Vascular Endothelial Cells

1996 • 76 citations

Bestrophin Interacts Physically and Functionally with Protein Phosphatase 2A

2002 • 73 citations

The cystic fibrosis transmembrane conductance regulator attenuates the endogenous Ca 2+ activated Cl - conductance of Xenopus oocytes

1997 • 73 citations

Non‐pore lining amino acid side chains influence anion selectivity of the human CFTR Cl⁻ channel expressed in mammalian cell lines

1998 • 73 citations

Dynamics of calcium regulation of chloride currents inXenopusoocytes

1999 • 72 citations

RhoA exerts a permissive effect on volume-regulated anion channels in vascular endothelial cells

2002 • 70 citations

Regulation of a Human Chloride Channel

2001 • 69 citations

Kinetic and pharmacological properties of the calciumm-activated chloride-current in macrovascular endothelial cells

1997 • 69 citations

Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl− channels

1999 • 67 citations

Molecular and Functional Characterization of a Murine Calcium-activated Chloride Channel Expressed in Smooth Muscle

2002 • 66 citations

Mechanical Forces and the Endothelium

1999 • 66 citations

Extracellular Zinc Ion Inhibits ClC-0 Chloride Channels by Facilitating Slow Gating

1998 • 66 citations

Novel Anion Dependence of Induced Cation Transport in Malaria-infected Erythrocytes

1995 • 65 citations

Pore stoichiometry of a voltage-gated chloride channel

1998 • 64 citations

Functional Geometry of the Permeation Pathway of Ca2+-activated Cl− Channels Inferred from Analysis of Voltage-dependent Block

2001 • 64 citations

Block by fluoxetine of volume‐regulated anion channels

1999 • 63 citations

Perspective: The List of Potential Volume-sensitive Chloride Currents Continues to Swell (and Shrink)

1998 • 62 citations

Identification of an acid-activated Cl⁻channel from human skeletal muscles

1999 • 62 citations

Inhibition of Volume-Regulated Anion Channels by Dominant-Negative Caveolin-1

2001 • 61 citations

Pharmacological Characterization of Chloride Channels Belonging to the ClC Family by the Use of Chiral Clofibric Acid Derivatives

2000 • 61 citations

Mechanisms of CFTR regulation by syntaxin 1A and PKA

2002 • 60 citations

Independent gating of single pores in CLC-0 chloride channels

1997 • 60 citations

Functional characterization of recombinant human ClC‐4 chloride channels in cultured mammalian cells

2002 • 60 citations

Functional Expression of p64, an Intracellular Chloride Channel Protein

1998 • 60 citations

Sulphonic acid derivatives as probes of pore properties of volume‐regulated anion channels in endothelial cells

1999 • 59 citations

Aquaporin 3 cloned from Xenopus laevis is regulated by the cystic fibrosis transmembrane conductance regulator

2000 • 58 citations

pICln Binds to a Mammalian Homolog of a Yeast Protein Involved in Regulation of Cell Morphology

1998 • 58 citations

Inhibition of volume‐regulated anion channels by expression of the cystic fibrosis transmembrane conductance regulator

1999 • 57 citations

Comparison of the properties of CLCA1 generated currents and I_Cl(Ca) in murine portal vein smooth muscle cells

2002 • 55 citations

The Chloride Channel ClC-4 Co-localizes with Cystic Fibrosis Transmembrane Conductance Regulator and May Mediate Chloride Flux across the Apical Membrane of Intestinal Epithelia

2002 • 55 citations

ClC chloride channels.

2001 • 55 citations

Chloride channels go cell cycling

2001 • 54 citations

Chapter 1 Voltage-Dependent Chloride Channels in Plant Cells: Identification, Characterization, and Regulation of a Guard Cell Anion Channel

1994 • 53 citations

Identification of a Novel Chloride Channel Expressed in the Endoplasmic Reticulum, Golgi Apparatus, and Nucleus

2001 • 53 citations

Cystic fibrosis transmembrane conductance regulator activates water conductance in Xenopus oocytes

1997 • 53 citations

Volume regulation in the bovine lens and cataract. The involvement of chloride channels.

1996 • 52 citations

Cardiac chloride channels

1993 • 51 citations

Chloride Channels and Hepatocellular Function: Prospects for Molecular Identification

2002 • 50 citations

Inhibition of angiogenesis by blockers of volume-regulated anion channels

2000 • 50 citations

NCC27, a homolog of intracellular Cl⁻channel p64, is expressed in brush border of renal proximal tubule

1998 • 49 citations

Modulation of volume-regulated anion channels by extra- and intracellular pH

1998 • 48 citations

ClC-2 Cl⁻ channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole

2001 • 48 citations

A cluster of negative charges at the amino terminal tail of CFTR regulates ATP‐dependent channel gating

2001 • 48 citations

Voltage-dependent block of endothelial volume-regulated anion channels by calix[4]arenes

1998 • 46 citations

Reduction of ionic strength activates single volume-regulated anion channels (VRAC) in endothelial cells

1999 • 46 citations

Drastic reduction of the slow gate of human muscle chloride channel (ClC‐1) by mutation C277S

2001 • 46 citations

Inhibition of volume-regulated and calcium-activated chloride channels by the antimalarial mefloquine.

2000 • 45 citations

The Large Conductance Potassium Channel β-Subunit Can Interact with and Modulate the Functional Properties of a Calcium-activated Chloride Channel, CLCA1

2002 • 44 citations

Ins(3,4,5,6)P4 specifically inhibits a receptor-mediated Ca2+-dependent Cl- current in CFPAC-1 cells

1997 • 43 citations

Dual effect of fluid shear stress on volume-regulated anion current in bovine aortic endothelial cells

2002 • 43 citations

Okadaic acid‐sensitive activation of Maxi Cl⁻ channels by triphenylethylene antioestrogens in C1300 mouse neuroblastoma cells

2001 • 43 citations

Modulation of the gating of ClC‐1 by S‐(–) 2‐(4‐chlorophenoxy) propionic acid

1999 • 41 citations

Myosin light chain phosphorylation‐dependent modulation of volume‐regulated anion channels in macrovascular endothelium

2000 • 41 citations

Pathophysiology of KCNQ Channels: Neonatal Epilepsy and Progressive Deafness

2000 • 41 citations

ATP Dependence of the ICl, swell Channel Varies with Rate of Cell Swelling

1999 • 40 citations

GOLAC: An Endogenous Anion Channel of the Golgi Complex

2000 • 39 citations

A Large-Conductance Chloride Channel in Pigmented Ciliary Epithelial Cells Activated by GTPγS

1997 • 39 citations

Chlorotoxin does not inhibit volume‐regulated, calcium‐activated and cyclic AMP‐activated chloride channels

2000 • 39 citations

The C-terminal part of the R-domain, but not the PDZ binding motif, of CFTR is involved in interaction with Ca 2+ -activated Cl - channels

2001 • 38 citations

ICln Is Essential for Cellular and Early Embryonic Viability

2000 • 38 citations

Asymmetric Structure of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore Suggested by Mutagenesis of the Twelfth Transmembrane Region

2001 • 37 citations

Inhibition of volume‐regulated anion channels in cultured endothelial cells by the anti‐oestrogens clomiphene and nafoxidine

2001 • 37 citations

Down-regulation of volume-sensitive Cl - channels by CFTR is mediated by the second nucleotide-binding domain

2002 • 36 citations

Modulation of the decay of Ca²⁺‐activated Cl⁻ currents in rabbit portal vein smooth muscle cells by external anions

1999 • 35 citations

Residues Lining the Inner Pore Vestibule of Human Muscle Chloride Channels

2001 • 34 citations

Extra- and Intracellular Proton-Binding Sites of Volume-Regulated Anion Channels

2000 • 34 citations

Volume-activated chloride currents are not correlated with P-glycoprotein expression

1995 • 32 citations

Potent block of volume‐activated chloride currents in endothelial cells by the uncharged form of quinine and quinidine

1996 • 31 citations

Inhibition of VRAC by c-Src tyrosine kinase targeted to caveolae is mediated by the Src homology domains

2001 • 30 citations

Inhibition by inositoltetrakisphosphates of calcium- and volume-activated Cl - currents in macrovascular endothelial cells

1998 • 30 citations

From stones to bones: The biology of ClC chloride channels

2001 • 29 citations

Volume-regulatory Amino Acid Release from the Protozoan Parasite Crithidia luciliae

1996 • 26 citations

Of Mice and Worms: Novel Insights Into ClC-2 Anion Channel Physiology

2002 • 26 citations

Role of CFTR’s PDZ1-binding domain, NBF1 and Cl− conductance in inhibition of epithelial Na+ channels in Xenopus oocytes

2001 • 22 citations

Lack of correlation between mdr-1 expression and volume-activation of cloride-currents in rat colon cancer cells

1995 • 22 citations

Activation of cAMP‐dependent Cl⁻ currents in guinea‐pig Paneth cells without relevant evidence for CFTR expression

1998 • 22 citations

Modulation of I Cl(Ca) in vascular smooth muscle cells by oxidizing and cysteine-reactive reagents

2002 • 19 citations

Myotonias due to CLC-1 chloride channel mutations.

1995 • 15 citations

Stimulatory and Inhibitory Functions of the R Domain on CFTR Chloride Channel

2000 • 12 citations

Calcium-activated chloride channels in vascular endothelial cells

2002 • 7 citations

Gene Expression Profiles of CLC Chloride Channels in Animal Models with Different Cardiovascular Diseases

2001 • 6 citations

Modulation of intracellular free Ca2+ concentration by mechanostrcss in human aortic endothelial cells

1997 • 1 citations