Cellular Senescence revisited: a review

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

1975 • 4,443 citations

QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

1963 • 2,742 citations

Calcium-Regulated Differentiation of Normal Human Epidermal Keratinocytes in Chemically Defined Clonal Culture and Serum-Free Serial Culture

1983 • 1,088 citations

Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes

1977 • 1,063 citations

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

1970 • 1,002 citations

Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium

1952 • 1,001 citations

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

1974 • 738 citations

Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase.

1985 • 640 citations

Characteristics of a Human Diploid Cell Designated MRC-5

1970 • 593 citations

The relationship between in vitro cellular aging and in vivo human age.

1976 • 559 citations

Cellular senescence and DNA synthesis

1973 • 537 citations

ON THE PERMANENT LIFE OF TISSUES OUTSIDE OF THE ORGANISM

1912 • 473 citations

KINKING OF THE INTERNAL CAROTID ARTERY

1961 • 431 citations

Integrated control of growth and differentiation of normal human prokeratinocytes cultured in serum‐free medium: Clonal analyses, growth kinetics, and cell cycle studies

1984 • 414 citations

Low oxygen concentration extends the lifespan of cultured human diploid cells

1977 • 387 citations

Characterization of a New Human Diploid Cell Strain, IMR-90

1977 • 371 citations

Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo

1981 • 348 citations

[6] The growth of cells in serum-free hormone-supplemented media

1979 • 330 citations

SV₄₀‐induced transformation of human diploid cells: Crisis and recovery

1965 • 317 citations

Clonal selection, attenuation and differentiation in an in vitro model of hyperplasia.

1974 • 304 citations

Role of fibronectin as a growth factor for fibroblasts.

1983 • 298 citations

Intraclonal Variation in Proliferative Potential of Human Diploid Fibroblasts: Stochastic Mechanism for Cellular Aging

1980 • 290 citations

Evidence for the Recessive Nature of Cellular Immortality

1983 • 286 citations

The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study.

1968 • 276 citations

Human Skin Fibroblasts Derived from Papillary and Reticular Dermis: Differences in Growth Potential in Vitro

1979 • 276 citations

Improved medium for clonal growth of human diploid fibroblasts at low concentrations of serum protein

1977 • 272 citations

VARIATION IN THE LIFE-SPAN OF CLONES DERIVED FROM HUMAN DIPLOID CELL STRAINS

1974 • 272 citations

The division cycle and RNA-synthesis in diploid human cells at different passage levels in vitro

1966 • 271 citations

Hormones and cell culture

1978 • 269 citations

The keratinocyte as differentiated cell type.

1980 • 260 citations

Evidence for a functional role of endogenously produced somatomedinlike peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells.

1985 • 257 citations

Is Cell Aging Caused by Respiration-Dependent Injury to the Mitochondrial Genome?

1982 • 242 citations

Limited and unlimited growth of sv40-transformed cells from human diploid mrc-5 fibroblasts

1983 • 241 citations

MORPHOLOGIC CHANGES ACCOMPANYING SENESCENCE OF CULTURED HUMAN DIPLOID CELLS

1970 • 239 citations

Transformation of Cultures of Human Tissue Infected with Simian Virus SV₄₀

1962 • 237 citations

The Cell Biology of Human Aging

1976 • 235 citations

Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress

1982 • 230 citations

Lung Maturation in the Fetal Rat: Acceleration by Injection of Fibroblast-Pneumonocyte Factor

1979 • 213 citations

Neoplastic transformation of human diploid fibroblast cells by chemical carcinogens

1978 • 204 citations

Biological activity of purified simian virus 40 T antigen proteins.

1978 • 197 citations

Existence of High Abundance Antiproliferative mRNA's in Senescent Human Diploid Fibroblasts

1986 • 194 citations

ANEUPLOIDY IN THE DEGENERATIVE PHASE OF SERIAL CULTIVATION OF HUMAN CELL STRAINS

1963 • 193 citations

Chronologic and Physiologic Age Affect Replicative Life-Span of Fibroblasts from Diabetic, Prediabetic, and Normal Donors

1978 • 188 citations

DIABETES MELLITUS AND AGING: DIMINISHED PLATING EFFICIENCY OF CULTURED HUMAN FIBROBLASTS

1969 • 186 citations

Ultrastructural changes accompanying the aging of human diploid cells in culture

1972 • 178 citations

Viability of human diploid cells as a function ofin vitro age

1969 • 175 citations

Colony size distributions as a measure of in vivo and in vitro aging.

1978 • 174 citations

Regulation of proliferation of fibroblasts of low and high population doubling levels grown in collagen lattices

1981 • 170 citations

Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos.

1976 • 166 citations

Genealogies of clones of diploid fibroblasts

1974 • 165 citations

Neoplastic transformation of human diploid cells in vitro after chemical carcinogen treatment

1978 • 164 citations

Doubling potential, calendar time, and donor age of human diploid cells in culture

1974 • 164 citations

UV-induced extracellular factor from human fibroblasts communicates the UV response to nonirradiated cells

1984 • 162 citations

Relationship between cell replication and volume in senescent human diploid fibroblasts

1976 • 159 citations

In Vitro Assessment of Keratinocyte Aging

1983 • 157 citations

Dominance of the Senescent Phenotype in Heterokaryons Between Replicative and Post-Replicative Human Fibroblast-Like Cells

1974 • 157 citations

Werner's syndrome

1973 • 154 citations

A new human diploid cell strain, TIG-1, for the research on cellular aging

1980 • 154 citations

Variegated translocation mosaicism in human skin fibroblast cultures

1975 • 153 citations

Senescent Human Diploid Cells in Culture: Survival, DNA Synthesis and Morphology

1979 • 152 citations

LIFESPAN OF CULTURED CELLS IN PROGERIA

1969 • 149 citations

The effect of donor age on the in vitro life span of cultured human arterial smooth-muscle cells

1978 • 147 citations

Aging in Cell and Tissue Culture

1970 • 146 citations

The Cell Cycle

1981 • 141 citations

Proliferative capacity and DNA content of aging human diploid cells in culture: A cytophotometric and autoradiographic analysis

1974 • 141 citations

Rapid clonal growth and serial passage of human diploid fibroblasts in a lipid-enriched synthetic medium supplemented with epidermal growth factor, insulin, and dexamethasone.

1981 • 139 citations

Mutation frequency in human lymphocytes increases with age

1984 • 138 citations

Doubling potential, calendar time, and senescence of human diploid cells in culture

1973 • 138 citations

Characterization of the cell cycle of cultured human diploid cells: Effects of aging and hydrocortisone

1977 • 137 citations

Action of cortisone on human fibroblasts in vitro

1966 • 135 citations

Human cell transformation by simian virus 40—A review

1981 • 135 citations

An Endocrine Approach to the Control of Epidermal Growth: Serum-Free Cultivation of Human Keratinocytes

1981 • 134 citations

Decreased fidelity of DNA polymerase activity isolated from aging human fibroblasts.

1976 • 132 citations

The Biology of Aging

1971 • 130 citations

Variables controlling somatomedin production by cultured human fibroblasts

1983 • 129 citations

Limited lifespan in somatic cell hybrids and cybrids

1980 • 128 citations

Neoplastic transformation of human diploid fibroblasts (KMST‐6) by treatment with ⁶⁰Co gamma rays

1985 • 127 citations

The effect of histamine on the growth of cultured fibroblasts isolated from normal and keloid tissue

1977 • 126 citations

Deficient DNA Repair in Human Progeroid Cells

1973 • 126 citations

A 57,000-mol-wt protein uniquely present in nonproliferating cells and senescent human fibroblasts.

1985 • 125 citations

CULTURE CHARACTERISTICS OF HUMAN FIBROBLASTS PROPAGATED SERIALLY

1957 • 125 citations

Expression of SV40 T antigen in finite life-span hybrids of normal and SV40-transformed fibroblasts

1981 • 123 citations

Recent developments in the age-related alteration of enzymes: A review

1977 • 120 citations

DNA repair in late-passage human cells

1976 • 117 citations

Status of mitochondria in living human fibroblasts during growth and senescence in vitro: use of the laser dye rhodamine 123.

1981 • 117 citations

The influence of host and tissue age on life span and growth rate of serially transplanted mouse mammary gland

1971 • 116 citations

Increased nuclear sizes in senescent human diploid fibroblast cultures

1976 • 114 citations

Adult, foetal and transformed fibroblasts display different migratory phenotypes on collagen gels: Evidence for an isoformic transition during foetal development

1985 • 114 citations

In vitro aging of human bone marrow derived stromal cells

1981 • 113 citations

Progressive Loss of the Proliferative Response of Senescing Wi-38 Cells to Platelet-derived Growth Factor, Epidermal Growth Factor, Insulin, Transferrin, and Dexamethasone

1984 • 113 citations

Rapid transformation of human fibroblasts with low growth potential into established cell lines by SV₄₀

1963 • 112 citations

Inhibition of the division cycle in confluent cultures of human fibroblasts in vitro

1966 • 112 citations

Long-Term Culture of Human Adult Liver Cells: Morphological Changes Related to <i>in vitro</i> Senescence and Effect of Donor’s Age on Growth Potential

1973 • 109 citations

Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts

1981 • 109 citations

Cellular Senescence in a Cloned Strain of Bovine Fetal Aortic Endothelial Cells

1980 • 106 citations

Evidence for Different Gestation-Dependent Effects of Cortisol on Cultured Fetal Lung Cells

1974 • 106 citations

The growth promoting effect of cortisol on human fetal lung cells

1973 • 106 citations

Cellular aging--clonal senescence. A review (Part I).

1977 • 105 citations

The use of frequency distributions of cell diameters to characterize cell populations in tissue culture

1967 • 103 citations

Diminished in vitro tyrosine kinase activity of the EGF receptor of senescent human fibroblasts

1983 • 102 citations

Replication Rate and Lifespan of Cultured Fibroblasts in Down's Syndrome

1972 • 101 citations

Progeria: a cell culture study on aging

1971 • 100 citations

Longevity, aging and comparative cellular and molecular biology of the house mouse, Mus musculus, and the white-footed mouse, Peromyscus leucopus.

1978 • 99 citations

The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum life span of mammals

1981 • 99 citations

Growth Factor Responsiveness of Cultured Human Fibroblasts Declines with Age

1983 • 99 citations

Nuclear control of cellular aging demonstrated by hybridization of anucleate and whole cultured normal human fibroblasts

1975 • 98 citations

Tissue-specific differences in cultured human diploid fibroblasts

1977 • 97 citations

Extension of the Lifespan of Cultured Normal Human Diploid Cells by Vitamin E

1974 • 96 citations

Loss of reiterated DNA sequences during serial passage of human diploid fibroblasts

1980 • 96 citations

Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential.

1975 • 96 citations

Absence of correlation between DNA repair in ultraviolet irradiated mammalian cells and life span of the donor species.

1980 • 95 citations

Cell Size and Nucleic Acid Content in the Diploid Human Cell Line WI-38 During Aging

1969 • 94 citations

Aging of human fibroblasts in vitro

1975 • 93 citations

The formation of altered enzymes in aging animals

1979 • 93 citations

Man, The Unknown

1935 • 93 citations

Parameters of aging in chicken embryo fibroblasts cultivated in vitro

1972 • 92 citations

Comparative heterokaryon study of cellular senescence and the serum-deprived state

1980 • 92 citations

Measurement of DNA content and cell volume in senescent human fibroblasts utilizing flow multiparameter single cell analysis

1976 • 92 citations

Lysosomal enzymes and aging in vitro: Subcellular enzyme distribution and effect of hydrocortisone on cell life-span☆

1975 • 92 citations

Growth factor responsiveness declines during adulthood for human skin-derived cells

1986 • 91 citations

Rate of DNA repair in progeric and normal human fibroblasts

1974 • 90 citations

Reinitiation of cellular DNA synthesis in BrdU‐selected nondividing senescent WI‐38 cells by simian virus 40 infection

1985 • 90 citations

Survival and Growth Requirements of Nontransformed Cells

1981 • 90 citations

Aging in vitro

1974 • 89 citations

Deficient repair of DNA lesions in Alzheimer's disease fibroblasts

1985 • 89 citations

Metabolic Aspects of Aging in Diploid Human Cells

1970 • 88 citations

Cultured human fibroblasts: Distribution of cell generations and a critical limit

1978 • 88 citations

Growth of cells in hormonally defined media

1983 • 88 citations

Replicative potentials of various fusion products between WI-38 and SV40 transformed WI-38 cells and their components

1980 • 87 citations

Increased organization of cytoskeleton accompanying the aging of human fibroblasts in vitro*1

1984 • 87 citations

Adult mouse dorsal root ganglia neurons in cell culture

1977 • 87 citations

The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro.

1977 • 86 citations

Cell size in aging monolayer cultures

1977 • 85 citations

DNA Repair in a Short-and a Long-lived Rodent Species

1979 • 84 citations

Extrachromosomal circular copies of an ‘inter-Alu’ unstable sequence in human DNA are amplified during in vitro and in vivo ageing

1983 • 84 citations

[125I]EGF binding ability is stable throughout the replicative life-span of WI-38 cells

1983 • 84 citations

Aging and the alteration of enzymes: A review

1975 • 83 citations

Comparative ultrastructure of chick fibroblasts in vitro at early and late stages during their growth span

1971 • 82 citations

Posttranslational Modifications of Enzymes

1978 • 82 citations

Relationship between Actinic Damage and Chronologic Aging in Keratinocyte Cultures of Human Skin

1979 • 82 citations

Correlation between ultraviolet-induced DNA repair in primate lymphocytes and fibroblasts and species maximum achievable life span

1984 • 81 citations

Heterogeneity of the kinetics of proliferation within human skin fibroblastic cell populations

1982 • 81 citations

In vitro proliferation and lifespan of bovine aorta endothelial cells: Effect of culture conditions and fibroblast growth factor

1980 • 80 citations

Rapid disappearance of statin, a nonproliferating and senescent cell-specific protein, upon reentering the process of cell cycling.

1985 • 79 citations

Alteration in cellular RNAs during the in Vitro lifespan of cultured human diploid fibroblasts

1975 • 78 citations

Analysis of Virus Replication in Ageing Human Fibroblast Cultures

1973 • 78 citations

ANALOGY IN GROWTH BETWEEN LATE PASSAGE HUMAN EMBRYONIC AND EARLY PASSAGE HUMAN ADULT FIBROBLASTS

1969 • 76 citations

Cell Impairment in Aging and Development

1975 • 76 citations

The influence of mammogenic hormones on serially transplanted mouse mammary gland

1971 • 75 citations

Ploidy of Human Embryonic Fibroblasts During in Vitro Aging

1982 • 75 citations

Respiration and glycolysis in the human diploid cell strain wi‐38

1966 • 75 citations

Skin fibroblasts obtained from cancer patients display foetal-like migratory behaviour on collagen gels

1985 • 75 citations

Cellular aging studied by the reconstruction of replicating cells from nuclei and cytoplasms isolated from normal human diploid cells

1976 • 75 citations

RAPID TRANSFORMATION OF HUMAN FIBROBLAST CULTURES BY SIMIAN VIRUS 40

1963 • 75 citations

Histone acetylation during aging of human cells in culture

1972 • 74 citations

Intracellular determinants of cell aging

1984 • 73 citations

Ongoing DNA synthesis continues in young human diploid cells (HDC) fused to senescent HDC, but entry into S phase is inhibited

1980 • 73 citations

In vitro proliferation and lifespan of human diploid fibroblasts in serum‐free BSA‐containing medium

1982 • 73 citations

Senescence of cultured human fibroblasts: Mitotic versus metabolic time

1974 • 73 citations

Oxygen-sensitive stages of the cell cycle of human diploid cells.

1978 • 72 citations

Cellular Aging in Werner's Syndrome: A Unique Phenotype?

1979 • 72 citations

Synthesis of extracellular matrix glycoproteins by cultured microvascular endothelial cells isolated from the dermis of neonatal and adult skin

1985 • 72 citations

Repair replication in cultured normal and transformed human fibroblasts

1976 • 71 citations

Functional Failures of Cultured Human Diploid Fibroblasts After Continued Population Doublings

1971 • 71 citations

Continued in vitro growth of fibroblast-like cells (RBCF-1) derived from the caudal fin of the fish, Carassius auratus

1980 • 71 citations

Establishment and characterization of chicken embryo fibroblast clone LSCC-H32

1982 • 70 citations

Insulin‐like growth factor I/somatomedin‐C (IGF‐I/SM‐C) and glucocorticoids synergistically regulate mitosis in competent human fibroblasts

1983 • 70 citations

The role of fibroblast growth factor and the extracellular matrix in the control of proliferation and differentiation of corneal endothelial cells

1981 • 70 citations

Growth regulation of WI38 cells in a serum-free medium

1981 • 69 citations

Carotenoids and retinol: their possible importance in determining longevity of primate species.

1984 • 68 citations

Autocrine and paracrine growth stimulation of cells derived from human skin

1983 • 68 citations

Application of a unique monoclonal antibody as a marker for nonproliferating subpopulations of cells of some tissue.

1985 • 68 citations

Long-term growth of chicken fibroblasts on a collagen substrate

1974 • 68 citations

Energy metabolism in cultured human fibroblasts during aging in vitro

1982 • 68 citations

Enzyme activity during the growth and aging of human cells in vitro

1967 • 68 citations

Appearance of extrachromosomal circular DNAs during in vivo and in vitro ageing of mammalian cells

1985 • 68 citations

Prior Chronic Sun Exposure Decreases the Lifespan of Human Skin Fibroblasts in Vitro

1980 • 68 citations

Chronologic and actinically induced aging in human facial skin.

1983 • 68 citations

The influence of culture medium volume on cell density and lifespan of human diploid fibroblasts

1975 • 67 citations

Phenotype of low proliferative potential is dominant in hybrids of normal human fibroblasts

1982 • 67 citations

Enzyme levels of normal human cells: Aging in culture

1975 • 67 citations

SV40‐transformed human fibroblasts: Evidence for cellular aging in precrisis cells

1985 • 66 citations

A quantitative analysis of the aging of human glial cells in culture

1983 • 66 citations

Aging of human fibroblasts is a succession of subtle changes in the cell cycle and has a final short stage with abrupt events

1982 • 65 citations

Observations on the senescence of cells derived from articular cartilage

1983 • 65 citations

THE PERMANENT LIFE OF CONNECTIVE TISSUE OUTSIDE OF THE ORGANISM

1913 • 65 citations

A correlation between aging and DNA repair in human epidermal cells

1984 • 64 citations

Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts

1982 • 64 citations

Increased error frequency of DNA polymerases from senescent human fibroblasts

1981 • 64 citations

Chromatin structure and function in proliferating cells

1976 • 63 citations

METABOLIC STUDIES IN TWO BOYS WITH CLASSICAL PROGERIA

1969 • 63 citations

Density‐dependent effects of oxygen on the growth of mammalian fibroblasts in culture

1978 • 63 citations

Establishment of mouse embryo cells in vitro

1977 • 62 citations

Human Genetic Disorders That Feature Premature Onset and Accelerated Progression of Biological Aging

1978 • 62 citations

Serum Albumin Supplemented Medium for Long Term Cultivation of Mammalian Fibroblast Strains.

1964 • 61 citations

Evidence contrary to the protein error hypothesis for in vitro senescence

1976 • 61 citations

Metabolic studies in two boys with classical progeria.

1969 • 61 citations

Chronologic and Actinically Induced Aging in Human Facial Skin

1983 • 60 citations

Observations on the morphological heterogeneity of WI‐38 cells

1977 • 59 citations

Progress of aging in human diploid cells transformed with a tsA mutant of simian virus 40

1984 • 59 citations

Are cross-bridging structures involved in the bundle formation of intermediate filaments and the decrease in locomotion that accompany cell aging?

1985 • 59 citations

Thymidine triphosphate synthesis in senescent WI38 cells

1983 • 58 citations

Reinitiation of host DNA synthesis in senescent human diploid cells by infection with simian virus 40

1983 • 58 citations

Collagen synthesized and modified by aging fibroblasts in culture

1975 • 58 citations

A re‐evaluation of the changes in proliferation in human fibroblasts during ageing in vitro

1982 • 58 citations

Similarity between in vitro and in vivo cellular aging

1983 • 58 citations

Evidence for endogenous polypeptide-mediated inhibition of cell-cycle transit in human diploid cells.

1982 • 57 citations

Carcinogen-transformed human cells are inhibited from entry into S phase by fusion to senescent cells but cells transformed by DNA tumor viruses overcome the inhibition.

1982 • 57 citations

Usage of vertebrate, invertebrate and plant cell, tissue and organ culture terminology

1984 • 57 citations

Primary culture of human diploid cells and its long-term transfer in a serum-free medium

1981 • 56 citations

Multiplication of human diploid fibroblasts in a synthetic medium supplemented with EGF, insulin, and dexamethasone

1981 • 56 citations

The source of cellular lipid in the human diploid cell strain WI-38

1969 • 55 citations

Hydrocortisone effects on cell proliferation: Specificity of response among various cell types

1977 • 55 citations

Characterization of fractionated human diploid fibroblast cell populations

1976 • 54 citations

Interaction of fibronectin with collagen: age-specific defect in the biological activity of human fibroblast fibronectin.

1983 • 54 citations

Chromatin template activity during aging in WI38 cells

1975 • 53 citations

Evidence for in vitro senescence of T-lymphocytes cultured from normal human peripheral blood

1981 • 53 citations

Isolation of autofluorescent ‘aged’ human fibroblasts by flow sorting

1982 • 52 citations

Studies on Age-related Diseases in Cultured Skin Fibroblasts

1979 • 52 citations

Fidelity of protein synthesis does not decline during aging of cultured human fibroblasts

1980 • 52 citations

Strict relationship between dialyzed serum concentration and cellular life span in vitro

1979 • 52 citations

Increased adhesiveness of Down syndrome fetal fibroblasts in vitro.

1984 • 51 citations

Age dependent production of a competence factor by human fibroblasts

1983 • 51 citations

Intramitotic variation in proliferative potential: Stochastic events in cellular aging

1985 • 51 citations

Extension of the lifespan of cultured normal human diploid cells by vitamin E: a reevaluation.

1977 • 51 citations

Inhibition of DNA synthesis in senescent-proliferating human cybrids is mediated by endogenous proteins

1984 • 50 citations

Fibronectin from aged fibroblasts is defective in promoting cellular adhesion

1980 • 50 citations

Effects of donor's age on growth kinetics of rabbit articular chondrocytes in culture

1983 • 50 citations

Decreased proteolysis and increased amino acid efflux in aging human fibroblasts

1976 • 50 citations

Normal DNA strand rejoining and absence of DNA crosslinking in progeroid and aging human cells

1976 • 49 citations

The lipids of normal diploid (WI‐38) and sv40‐transformed human cells

1969 • 49 citations

Changes in Specific Dexamethasone Binding during Aging in WI-38 Cells*

1981 • 49 citations

Inhibition of DNA synthesis in proliferating human diploid fibroblasts by fusion with senescent cytoplasts*1

1983 • 49 citations

DNA Repair Response in Human Epidermal Keratinocytes from Donors of Different Age

1982 • 48 citations

Rescue of senescent human fibroblasts by hybridization with hamster cells in vitro

1972 • 48 citations

Aging and Cultured Human Skin in Fibroblasts

1979 • 48 citations

Decreased sensitivity of old and progeric human fibroblasts to a preparation of factors with insulinlike activity.

1981 • 48 citations

Cellular Senescence in Vitro

1982 • 48 citations

Spontaneous transformation of human skin fibroblasts derived from neoplastic patients

1976 • 47 citations

Collagen synthesis in human fibroblasts: Effects of ascorbic acid and regulation by hydrocortisone

1981 • 47 citations

Clonal growth of primary human cell cultures

1964 • 46 citations

Aging of Cells in Culture

1984 • 46 citations

Age-related alterations in cultured human fibroblast membrane structure and function

1984 • 46 citations

Changes in cell-surface glycosaminoglycans in human diploid fibroblasts during in vitro aging

1981 • 45 citations

Hydrocortisone: A specific modulator of in vitro cell proliferation and aging

1979 • 45 citations

Growth and Glycolysis in the Human Diploid Cell Strain WI-38.

1965 • 45 citations

Clone size variation in the human diploid cell strain, wi‐38

1973 • 45 citations

INDUCTION OF DNA SYNTHESIS IN CULTURED NEURONS BY ULTRAVIOLET LIGHT OR METHYL METHANE SULFONATE

1972 • 45 citations

Genetic Effects on the Longevity of Cultured Human Fibroblasts. II

1983 • 45 citations

Inhbition of DNA synthesis in young cycling human diploid fibroblast-like cells upon fusion to enucleate cytoplasts from senescent cells

1983 • 44 citations

In vitro characterization of response to stimulus (wounding) with regard to ageing in human skin fibroblasts

1982 • 44 citations

Loss of organized fibronectin matrix from the surface of aging diploid fibroblasts (IMR-90)

1981 • 44 citations

Ultrastructural and cytochemical changes in cultured human lung cells

1972 • 44 citations

Effect of low dose rate irradiation on the division potential of cells in vitro

1976 • 44 citations

Expression of the transformation-sensitive protein "cyclin" in normal human epidermal basal cells and simian virus 40-transformed keratinocytes.

1984 • 44 citations

Serial Propagation of 3 Strains of Rabbit Fibroblasts; Their Susceptibility to Infection with Vaccinia Virus.

1956 • 44 citations

Neuronal aging in cultures; An electron-microscopic study

1973 • 43 citations

EFFECTS OF X-IRRADIATED FEEDER LAYERS ON MITOTIC ACTIVITY AND DEVELOPMENT OF ANEUPLOIDY IN MOUSE-EMBRYO CELLS IN VITRO.

1963 • 43 citations

PRESENT CONDITION OF A STRAIN OF CONNECTIVE TISSUE TWENTY-EIGHT MONTHS OLD

1914 • 43 citations

Premature Senescence in Cultured Skin Fibroblasts from Subjects with Cystic Fibrosis

1979 • 43 citations

Pathological implications of cell aging in vitro

1975 • 43 citations

Identification of an SV40 DNA sequence related to the reactivation of silent rRNA genes in human > mouse hybrid cells

1981 • 42 citations

Changes in enzymic activity during cultivation of human cells in vitro

1973 • 42 citations

Differences in growth response to hydrocortisone and ascorbic acid by human diploid fibroblasts

1977 • 42 citations

Age-related changes in the distribution pattern of glycosaminoglycans synthesized by cultured human diploid fibroblasts (WI-38)

1981 • 42 citations

Partial characterization of a mitogenic factor with somatomedin-like activity produced by culture WI-38 human fibroblasts

1981 • 42 citations

Apparent heterogeneity in the response of quiescent swiss 3T3 cells to serum growth factors: Implications for the transition probability model and parallels with “cellular senescence” and “competence”

1984 • 42 citations

Human cells transformed by SV40 revisited: The epithelial cells

1982 • 42 citations

Werner's syndrome

1978 • 41 citations

4F2 monoclonal antibody recognizes a surface antigen on spread human fibroblasts of embryonic but not of adult origin.

1984 • 40 citations

Evidence for clonal attenuation of growth potential in hela cells

1978 • 40 citations

Glycosaminoglycan synthesis and composition in human fibroblasts during in vitro cellular aging (IMR‐90)

1981 • 40 citations

DNA Synthesis in the Human Diploid Cell Strain WI-38 During in Vitro Aging: An Autoradiography Study

1979 • 40 citations

Nucleolar changes in senescing WI-38 cells

1978 • 40 citations

Viral Probes of Aging in the Human Diploid Cell Strain WI-38

1974 • 39 citations

Autofluorescent structures in cultured WI-38 cells

1974 • 39 citations

High-voltage electron microscopy of human diploid fibroblasts during ageing in vitro *1Morphometric analysis of mitochondria

1984 • 39 citations

Induction of the nuclear protein cyclin in serum-stimulated quiescent 3T3 cells is independent of DNA synthesis

1985 • 39 citations

Correlation between DNA excision repair and mammalian lifespan in lens epithelial cells

1982 • 39 citations

In vitro studies of age-associated diseases.

1979 • 39 citations

Attempted hybridizations with senescent human fibroblasts

1973 • 38 citations

The relative amounts of the cytoplasmic RNA species in normal, transformed and senescent cultured cell lines

1977 • 38 citations

Senescence of aortic endothelial cells in vitro: Influence of culture conditions and preliminary characterization of the senescent phenotype

1982 • 38 citations

Correlation between species life span and capacity to activate 7,12-dimethylbenz(a)anthracene to a form mutagenic to a mammalian cell

1975 • 38 citations

Prematurely condensed chromosomes of dividing and non-dividing cells in aging human cell cultures

1975 • 38 citations

Limited culture lifespan of human diploid cells as a function of metabolic time instead of division potential

1971 • 37 citations

DNA-binding proteins in young and senescent normal human fibroblasts

1975 • 37 citations

Effects of various steroids on in vitro lifespan and cell growth of human fetal lung fibroblasts (WI-38)

1983 • 36 citations

Glucocorticoid hormone modulation of both cell surface and cytoskeleton related to growth control of rat glioma cells.

1983 • 36 citations

Growth and differentiation of fetal rat small intestinal epithelium in tissue culture

1984 • 36 citations

Growth of human foreskin fibroblasts in a serum-free, defined medium without platelet-derived growth factor

1982 • 35 citations

The replicative life spans of euploid hybrids derived from short-lived and long-lived human skin fibroblast cultures

1978 • 35 citations

Inverse correlation between species life span and capacity of cultured fibroblasts to bind 7,12-dimethylbenz(a)anthracene to DNA

1977 • 35 citations

Increased degradation rates of protein in aging human fibroblasts and in cells treated with an amino acid analog

1976 • 35 citations

Decreased synthesis of nucleolar RNA in aging human cells in vitro

1976 • 35 citations

Protein turnover in senescent cultured chick embryo fibroblasts

1978 • 34 citations

Aging of endothelium in culture: Decrease in angiotensin-converting enzyme activity

1982 • 34 citations

Error Accumulation and Aging in Human Diploid Cells

1974 • 34 citations

Failure of hydrocortisone or growth factors to influence the senescence of fibroblasts in a new culture system for assessing replicative lifespan

1981 • 34 citations

Hydrocortisone as a Modulator of Cell Division and Population Life Span

1975 • 34 citations

Age-dependent changes in myogenic precursor cell compartment sizes *1Evidence for the existence of a stem cell

1984 • 33 citations

Evidence that a critical threshold of DNA polymerase‐alpha activity may be required for the initiation of DNA synthesis in mammalian cell heterokaryons

1982 • 33 citations

Senescence and Vascular Disease

1975 • 33 citations

Repair of X-ray-induced DNA damage in aging human diploid cells

1980 • 32 citations

Aging of chick embryo fibroblasts in vitro

1979 • 32 citations

Plasma membrane associated metabolic parameters and the aging of human diploid fibroblasts

1978 • 32 citations

Growth of human embryonic fibroblasts at clonal density: Concordance with results from mass cultures

1979 • 31 citations

DNA repair in cultured human fibroblasts does not decline with donor age

1982 • 31 citations

On the activity and fidelity of chromatin‐associated hepatic DNA polymerase‐β in aging murine species of different life spans

1981 • 31 citations

Properties of DNA polymerases from young and ageing human fibroblasts

1981 • 31 citations

Relationship of finite proliferative lifespan, senescence, and quiescence in human cells

1985 • 31 citations

Development of the aging cell surface

1979 • 30 citations

Genetic and evolutionary aspects of aging.

1979 • 30 citations

Normal level of unscheduled DNA synthesis in Werner's syndrome fibroblasts in culture

1978 • 30 citations

Characteristics of WI-38 cells (WI-38 CT-1) transformed by treatment with Co-60 gamma rays.

1980 • 30 citations

Age-related changes in unscheduled DNA synthesis by rat hepatocytes

1984 • 29 citations

Intermittent exposure to fluorescent light extends lifespan of human diploid fibroblasts in culture

1977 • 29 citations

Induction of DNA polymerase α in senescent cultures of normal and Werner's syndrome cultured skin fibroblasts

1985 • 29 citations

Structural comparisons of fibronectins isolated from early and late passage cells

1984 • 29 citations

Finite growth span of mouse mammary gland serially propagated in vivo

1973 • 29 citations

Werner's syndrome: a model of premature aging?

1978 • 28 citations

Loss of responsiveness in senescent human TIG-1 cells to the DNA synthesis-inducing effect of various growth factors

1984 • 28 citations

Multinucleation and Polyploidization of Aging Human Cells in Culture

1980 • 28 citations

Spontaneous In Vitro Transformation of Human Fibroblasts<xref ref-type="fn" rid="FN2">2</xref>

1984 • 28 citations

Relationship of heat labile glucose‐6‐phosphate dehydrogenase and multiple molecular forms of the enzyme in senescent human fibroblasts

1977 • 28 citations

THE ‘TRANSITION PROBABILITY MODEL’ AND THE REGULATION OF PROLIFERATION OF HUMAN DIPLOID CELL CULTURES DURING AGING

1976 • 27 citations

Cellular Senescence: Factors Modulating Cell Proliferation In Vitro

1985 • 27 citations

The Effect of Hydrocortisone on DNA Synthesis and Cell Division during Aging in Vitro

1975 • 27 citations

Changes in protein synthesis and breakdown rates and responsiveness to growth factors with ageing in human lung fibroblasts

1985 • 27 citations

Effects of density and cellular aging on collagen synthesis and growth kinetics in keloid and normal skin fibroblasts

1982 • 26 citations

Accuracy of in vitro protein synthesis: Translation of polyuridylic acid by cell-free extracts of human fibroblasts

1980 • 26 citations

A long-lived human diploid fibroblast line for cellular aging studies: Applications in cell hybridization

1982 • 26 citations

Correlation between the presence of T-antigen and the reinitiation of host DNA synthesis in senescent human diploid fibroblasts after SV40 infection

1983 • 26 citations

The Decreased Growth Potential in Vitro of Human Fibroblasts of Adult Origin

1970 • 26 citations

Changes in the synthesis of minor cartilage collagens after growth of chick chondrocytes in 5-bromo-2′-deoxyuridine or to senescence

1984 • 26 citations

Surface Labelling of Senescent Chick Fibroblasts by Lactoperoxidase-Catalysed Iodination

1976 • 25 citations

Structural alterations of chromatin in phase III WI38 human diploid fibroblasts

1975 • 25 citations

Cytological changes in senescing WI-38 cells: A statistical analysis

1979 • 25 citations

Kinetics of In vitro ageing of mouse embryo fibroblasts

1984 • 25 citations

Evidence that transcription changes in ageing cultures are terminal events occuring after the expression of a reduced replicative potential

1978 • 25 citations

Ultraviolet hypersensitivity of Cockayne's syndrome fibroblasts

1982 • 25 citations

Fibronectin distribution on the surfaces of young and old human fibroblasts

1984 • 25 citations

Increased lability of triosephosphate isomerase in progeria and Werner's syndrome fibroblasts

1982 • 25 citations

Lipid metabolism in aging

1972 • 25 citations

Genome reorganization during cellular senescence

1984 • 25 citations

Changes in NAD levels in human lymphocytes and fibroblasts during aging and in premature aging syndromes

1983 • 25 citations

Free fatty acids in cultured cells

1970 • 25 citations

Ageing of hamster embryo fibroblasts as the result of both differentiation and stochastic mechanisms

1983 • 24 citations

Hydrocortisone stimulates fibronectin synthesis in cultured fibroblasts

1984 • 24 citations

Age-related differences in intercellular adhesion for chick fibroblasts cultured in vitro

1974 • 24 citations

Modulation of cell proliferation and senescence of WI-38 cells by hydrocortisone.

1979 • 24 citations

Nucleocytoplasmic interactions in experimental binucleates formed from normal and transformed components

1979 • 24 citations

Decrease in the average size of replicons in a Werner syndrome cell line by Simian Virus 40 infection

1983 • 24 citations

Exposure of nondividing populations of primary human fibroblasts to UV (254 nm) radiation induces a transient enhancement in capacity to repair potentially lethal cellular damage.

1984 • 24 citations

Evidence for an increased level of DNA damage in high doubling level human diploid cells in culture

1981 • 24 citations

Development of the aging cell surface: Variation in the distribution of intramembrane particles with progressive age of human diploid fibroblasts

1977 • 24 citations

Glucocorticoid receptors in WI-38 fibroblasts Characterization and changes with population doubling in culture

1979 • 24 citations

Time-Lapse Cinemicrophotographic Studies of Cell Division Patterns of Human Diploid Fibroblasts (WI-38) during their in Vitro Lifespan

1975 • 23 citations

Protein synthesis during aging of human cells in culture

1975 • 23 citations

Autofluorescence of Human Skin Fibroblasts during Growth Inhibition and in vitro Ageing

1985 • 23 citations

Newborn human skin fibroblasts senesce in vitro without acquiring adult growth factor requirements*1

1984 • 22 citations

The in vitro cell culture age and cell density of articular chondrocytes alter sulfated-proteoglycan biosynthesis

1984 • 22 citations

DNA repair synthesis in rat retinal ganglion cells treated with chemical carcinogens or ultraviolet light in vitro, with special reference to aging and repair level.

1978 • 22 citations

Evidence for differences in the mechanism of cell cycle arrest between senescent and serum‐deprived human fibroblasts: Heterokaryon and metabolic inhibitor studies

1984 • 22 citations

Protein degradation in cell cultures: general considerations on mechanisms and regulation.

1980 • 22 citations

Glycosaminoglycan distribution in substratum adhesion sites of aging human skin fibroblasts, including papillary and reticular subpopulations

1985 • 22 citations

Fibroblast culture in Werner's syndrome

1971 • 22 citations

Aging dependent nucleolar and chromatin changes in cultivated fibroblasts

1983 • 21 citations

The Two-dimensional polypeptide profile of terminally non-dividing human diploid cells*1

1984 • 21 citations

Viral probe into the events of cellular (in vitro) aging

1974 • 21 citations

60Coガンマ線照射で形質転換したWI‐38細胞(WI‐38CT‐1)の特徴

1980 • 21 citations

Ultraviolet light-induced DNA repair synthesis in hepatocytes from species of differing longevities

1985 • 21 citations

Unscheduled DNA synthesis in human diploid cells of different donor ages

1981 • 21 citations

Functional changes in cellular fibronectin from late passage fibroblasts

1983 • 21 citations

Altered protein metabolism in arrested populations of aging human diploid fibroblasts

1976 • 21 citations

Membrane glycoprotein changes during the senescence of normal human diploid fibroblasts in culture

1985 • 20 citations

Cell replication and aging: in vitro and in vivo studies.

1979 • 20 citations

Dominance of the senescent phenotype in heterokaryons between replicative and post-replicative human fibroblast-like cells

1974 • 20 citations

Altered rates of collagen synthesis in in vitro aged human lung fibroblasts

1983 • 20 citations

A growth history comparison of the human diploid cells WI-38 and IMR-90: Proliferative capacity and cell sizing analysis

1979 • 20 citations

The lack of altered enzyme molecules in “senescent” mouse embryo fibroblasts in culture

1975 • 20 citations

Restriction enzyme analysis of mitochondrial DNA in aging human cells

1985 • 19 citations

Contributions of cytoplasmic factors to in vitro cellular senescence

1975 • 19 citations

Unscheduled DNA synthesis in cells of different shape in fibroblast cultures from donors of various ages

1981 • 19 citations

Influence of Age on Chromatin Transcription in Murine Tissues using an Heterologous and an Homologous RNA Polymerase

1976 • 19 citations

Spontaneous transformation of human fibroblast cultures derived from bronchial carcinomata

1976 • 19 citations

Messenger RNA regulation in human diploid fibroblasts

1977 • 19 citations

Correlation of DNA repair synthesis with ageing in mice, evidenced by quantitative authoradiography

1984 • 19 citations

Cell-cell contact promotes DNA synthesis in retinal glia but not in fibroblasts

1983 • 19 citations

Comparison between proliferative changes and nuclear events during ageing of human fibrobalsts in vitro

1982 • 19 citations

Analysis of cell division by time‐lapse cinematographic studies of hydrocortisone‐treated embryonic lung fibroblasts

1984 • 19 citations

Synthesis of the nuclear protein cyclin does not correlate directly with transformation in quail embryo fibroblasts

1985 • 19 citations

The lipids of human diploid cell strain WI-38.

1966 • 19 citations

Increase in DNA synthesis in Werner's syndrome cells by hybridization with normal human diploid and HeLa cells

1979 • 19 citations

Decreased protein synthesis of transforming lymphocytes from aged humans: Relationship to impaired mitogenesis with age

1985 • 18 citations

RNA and protein synthesis in cultured human fibroblasts derived from donors of various ages

1980 • 18 citations

Doubling potential and calendar time of human diploid cells in vitro

1979 • 18 citations

Macromolecular synthesis in human diploid fibroblasts

1978 • 18 citations

Heterogeneity of Acid Phosphatase in the Human Diploid Cell Strain WI-38.

1967 • 18 citations

Complementation between senescent human diploid cells and a thymidine kinase-deficient murine cell line

1977 • 18 citations

Chromatin structure, DNA synthesis and transcription through the lifespan of human embryonic lung fibroblasts

1984 • 18 citations

A comparison of DNA repair synthesis in primary hepatocytes from young and old rats

1985 • 17 citations

Neuronal aging in tissue and cell cultures: A review

1983 • 17 citations

Long-term cultivation of amphibian melanophores

1983 • 17 citations

Studies on phosphoglucose isomerase from cultured human fibroblasts: Absence of detectable ageing effects on the enzyme

1978 • 17 citations

Enhancement of mitogen response and surface marker analysis of lymphocytes from yuong and old donors after preliminary incubation in vitro

1985 • 17 citations

The Regulation of Cellular Aging by Nuclear Events in Cultured Normal Human Fibroblasts (WI-38)

1975 • 17 citations

Sialyltransferase activities of aging diploid fibroblasts

1979 • 17 citations

Microtubules and microfilaments in ageing hamster embryo fibroblasts in vitro

1983 • 16 citations

Replicative potential of individual cell hybrids derived from young and old donor human skin fibroblasts

1982 • 16 citations

The reproductive potential of normal mouse embryo fibroblasts during culture in vitro

1984 • 16 citations

Decrease in the density of DNA topological turns during in vitro aging of Syrian hamster cells

1982 • 16 citations

Effect of donor age on long-term culture of bone marrow in vitro

1984 • 16 citations

Aging in vitro and D‐glucose uptake kinetics of diploid human fibroblasts

1981 • 16 citations

Nuclear area changes in senescing human diploid fibroblasts

1978 • 16 citations

Progressive Changes of the Growth Characteristics of the Human Diploid Cells in Serial Cultivation <i>in Vitro</i>

1969 • 16 citations

Introduction

1976 • 16 citations

Development of the aging cell surface: A freeze-fracture analysis of gap junctions between human embryo fibroblasts aging in culture. A brief note

1976 • 16 citations

Actin in young and senescent fibroblasts

1978 • 16 citations

Reactivation of DNA synthesis in aging diploid human skin fibroblasts by fusion with mouse L karyoplasts, cytoplasts and whole L cells

1982 • 16 citations

DNA repair deficiencies and cellular senescence are unrelated in xeroderma pigmentosum cell lines

1984 • 16 citations

Cumulative population doublings as the determinant of chick cell lifespan in vitro

1981 • 16 citations

Involvement of ribonucleotide reductase activity in the senescence of normal human diploid fibroblasts

1982 • 16 citations

Induction of host DNA synthesis in senescent human diploid fibroblasts by infection with human cytomegalovirus

1984 • 16 citations

Modifications of Phosphoproteins and Protein Kinases Occurring with in vitro Aging of Cultured Human Cells

1982 • 15 citations

Clonal selection in cultured human fibroblasts: role of protein synthetic errors.

1982 • 15 citations

Replicative activity of isolated chromatin from proliferating and quiescent early passage and aging cultured mouse cells

1979 • 15 citations

Protein Variations Associated with in Vitro Aging of Human Fibroblasts and Quantitative Limits on the Error Catastrophe Hypothesis

1983 • 15 citations

TRANSFORMATION OF HUMAN FIBROBLASTS WITH D.N.A. OF CULTURED HUMAN RHABDOMYOSARCOMA CELLS

1974 • 15 citations

Inverse Correlation Between Species Life Span and Specific Cytochrome P-448 Content of Cultured Fibroblasts

1982 • 15 citations

Aldolase Activity and Cross-Reacting Material in Lymphocytes of Aged Individuals

1979 • 14 citations

Enhanced proliferation of WI38 cells in the presence of glucocorticoid-conditioned medium

1985 • 14 citations

A lack of correlation between decline in growth capacity and nuclear RNA synthesising activity in ageing human embryo cells in culture

1976 • 14 citations

Reduction of DNA synthesis in aging but still proliferating cells

1985 • 14 citations

Effect of Donor Age on Clonal Differentiation of Human Skin Fibroblasts in vitro

1985 • 14 citations

Age-dependent metabolic changes in cultured human fibroblasts

1985 • 13 citations

Changes in albumin uptake during the lifespan of human fibroblasts in vitro

1977 • 13 citations

Glutathione content of cultured human fibroblasts during in vitro ageing

1984 • 13 citations

Cell and tissue culture in aging research.

1967 • 13 citations

Reevaluation of DNA chain elongation rate in human diploid fibroblasts

1982 • 13 citations

Amplification of inter-Alu extrachromosomal DNA during cellular ageing: retraction and explanation

1985 • 13 citations

A comparison of the proliferative and replicative life span kinetics of cell cultures derived from monozygotic twins

1981 • 13 citations

Growth rate of control and beta-interferon-treated human fibroblast populations over the course of their in vitro life span.

1984 • 13 citations

Degradation of peptides and proteins of different sizes by homogenates of human MRC5 lung fibroblasts

1985 • 12 citations

Effects of serum from rabbits of various ages on cell proliferation

1985 • 12 citations

X-Linked Processes in Serially Passaged "Aging" Human Diploid Cells

1981 • 12 citations

Chromatin modification of chick embryo cells during in vitro senescence

1974 • 12 citations

In vitro proliferation and lifespan of bovine aorta endothelial cells: Response to conditioned media

1982 • 12 citations

Glucocorticoid-Induced Modulation of Insulin-Stimulated DNA Synthesis: Differential Responsiveness in Cell Cultures Derived from Donors of Different Ages

1985 • 12 citations

Equivalent Proliferation Potential Different Size Classes of Human Diploid Fibroblasts

1981 • 12 citations

Age-associated changes in glutamine synthetase activity in WI-38 cells

1978 • 12 citations

Spontaneous mutations in ageing human cells: Studies using a herpesvirus probe

1977 • 12 citations

Does capacity of DNA replication change during in vitro ageing?

1985 • 12 citations

Prostaglandin production and cellular aging

1981 • 11 citations

Surface proteins of young and senescent cultured avian fibroblasts

1977 • 11 citations

Lysosomal and mitochondrial heat labile enzymes in Werner's syndrome fibroblasts

1980 • 11 citations

Responsiveness of human lung diploid fibroblast ageing in vitro to epidermal growth factor: Saturation density and lifespan

1983 • 11 citations

Reduction of filamin in late passage human diploid fibroblasts (IMR-90)

1985 • 11 citations

Induction of Sister Chromatid Exchanges by Mitomycin C in Lymphocytes of Young and Old Human Donors

1984 • 10 citations

Plating efficiency measurements and the experimental control of ageing of adult human skin fibroblasts in vitro

1978 • 10 citations

Alterations in Chromatin Functions during Aging in Vitro

1975 • 10 citations

Regulation of cholesterol synthesis in skin fibroblasts derived from old people

1979 • 10 citations

Nucleohistone content during aging in tissue culture

1971 • 10 citations

Establishment of two chick embryo fibroblastic cell lines.

1984 • 10 citations

In vitro life span and “unscheduled DNA synthesis” in subconfluent cultures and clones of trisomic and normal diploid fibroblasts

1982 • 10 citations

Studies of Aging in Cultured Nervous System Tissue

1979 • 10 citations

Sequence of cell life phases in a finitely proliferative population of cultured rat cells: A genealogical study

1984 • 9 citations

Hydrocortisone stimulation of DNA synthesis in bromodeoxyuridine-selected non-dividing WI-38 cells

1982 • 9 citations

S-phase transit times as a function of age in human diploid fibroblasts

1984 • 9 citations

The effects of histones in vitro age, and culture state on the digestion of DNA by micrococcal nuclease and deoxyribonuclease I

1983 • 9 citations

Rat lens epithelial cells in vitro

1980 • 9 citations

On the importance of deoxyribonucleotide pools in the senescence of cultured human diploid fibroblasts

1985 • 9 citations

Enzyme Activities of Some Cultured Human Cells.

1967 • 9 citations

Senescence in vitro and ionising radiations—the human diploid fibroblast model

1981 • 9 citations

Neutral amino acid transport and in vitro aging

1984 • 9 citations

The influence of insulin in the cell cycle of human aging cells

1983 • 8 citations

Proliferative Response in Solid Culture of T Cells from Healthy Aged Subjects

1985 • 8 citations

Development of the aging cell surface: Structural patterns of gap junction assembly between metabolic mutants and progressively subcultivated human diploid fibroblasts (IMR-90)

1980 • 8 citations

Further evidence against the accumulation of altered enzymes in late passage embryonic mouse fibroblasts in vitro

1977 • 8 citations

Cytoplasts can transfer factor(s) that stimulate quiescent fibroblasts to enter S phase

1982 • 8 citations

Filopodia number increases with age and quiescence in populations of normal WI-38 cells, and is correlated with drug-induced changes in proliferation in both normal and transformed populations

1986 • 8 citations

A Comparison of Surface Antigens of Senescent and Presenescent Human Fibroblasts

1981 • 7 citations

Effects of in vitro aging and cell growth on the viability and recovery of human diploid fibroblasts, TIG-1, after freezing and thawing

1981 • 7 citations

Seeding efficiency, plating efficiency, and population doublings of human skin fibroblastlike cells: Results of replicate testing

1983 • 7 citations

DNA chain growth as a function of age in intact and permeabilized WI-38 and MRC-5 cells

1983 • 7 citations

Modulation of purine synthesis and phosphoribosyl-pyrophosphate content in human fibroblasts at different population doublings

1982 • 7 citations

Effect of age on the in vitro glucocorticoid-binding activity of rat adipocytes

1981 • 7 citations

Fibrin clot retractile (FCR) activity of fibroblast-like cells from normal individuals and cancer patients

1982 • 7 citations

The effect of clinical and subclinical concentrations of lead on the in vitro aging of human fibroblasts

1983 • 7 citations

Lactate dehydrogenase isozyme patterns of normal human fibroblasts and their in vitro-transformed counterparts obtained by treatment with CO-60 gamma-rays, SV40 or 4-nitroquinoline 1-oxide.

1981 • 6 citations

<i>In vitro</i> ‘Ageing’ and Nuclear Template Function

1980 • 6 citations

Identification and characterization of non-dividing cell populations in phase II cultures of human glial cells

1984 • 6 citations

Analysis of ribosomal RNA in human fibroblasts continuously treated with hydrocortisone

1983 • 6 citations

Enhanced endocytosis by aging chondrocytes and fibroblasts

1984 • 6 citations

Human diploid fibroblasts with alterations in ribonucleotide reductase activity, deoxyribonucleotide pools and in vitro lifespan

1984 • 6 citations

Ageing and the fusion sensitivity potential of human cells in culture: Relation to tissue origin, donor age, and in vitro culture level and condition

1981 • 6 citations

Altered DNA Repair in Fibroblasts from Aged Rats

1981 • 6 citations

Influence of Growth State on Relationship between Nuclear Template Activity and in vitro ‘Ageing’

1980 • 6 citations

The re-entry of long term density growth inhibited cells into the cell cycle

1983 • 6 citations

Cholesterol and cholesteryl ester concentration in different size classes of cultured human fibroblasts: Effect of in vitro aging

1982 • 6 citations

Decreased longevity of human diploid cells after incorporation of latex spheres within their cytoplasm

1981 • 6 citations

EFFECT OF LOW DOSE RATE IRRADIATION ON THE DIVISION POTENTIAL OF CHICK EMBRYONIC FIBROBLASTS.

1972 • 6 citations

Replicative activity and actinomycin binding in mouse diploid fibroblasts (in vitro ageing)

1983 • 5 citations

Growth-Promoting Alpha-Globulin and Ageing

1975 • 5 citations

No male-female difference in In vitro lifespan of skin fibroblasts from humans and mice

1983 • 5 citations

Tissue culture in aging research: Present status and prospects

1981 • 5 citations

Chromosome replication in aging human diploid fibroblasts

1982 • 5 citations

Effect of lead on fibroblasts taken from an 84-year-old donor

1985 • 5 citations

The effects of division rate‐limiting amounts of fetal bovine serum on the proliferation and aging of cultured chick cells

1982 • 5 citations

Effects of the Incorporation of p-Fluorophenylalanine on the in Vitro Lifespan of Human Diploid Cells

1979 • 4 citations

Determination of the nuclear RNA content of cells from donors of three different ages during in vitro senescence

1981 • 4 citations

Aging and Hydrocortisone Effects on Transient Structures of Replicative DNA of Human Fibroblasts

1982 • 4 citations

Genomic plasticity in aging human cells.

1984 • 4 citations

Complementation in heterokaryons derived from a thymidine kinase deficient cell line and senescent human diploid cells.

1979 • 4 citations

Hydrocortisone effects on nucleic acid and nuclear protein content and protein metabolism in aging WI-38 cells

1981 • 3 citations

Nucleolar RNA synthesis in heterokaryons derived from senescent and pre-senescent human fibroblasts

1980 • 3 citations

The growth of human diploid fibroblasts in serum-free medium.

1983 • 3 citations

Differences in the response of non-dividing human diploid fibroblasts (HDF) to inducers of DNA synthesis generated by cycling HDF and HeLa cells

1985 • 3 citations

Growth promotion by preventing G0-arrest does not enhance the replicative life span of human diploid fibroblasts

1981 • 3 citations

The energy status of aging cells in culture: the adenine nucleotide pool [proceedings].

1978 • 3 citations

The effects of in vitro ageing on the exopeptidases of human diploid fibroblasts

1984 • 3 citations

Low-Density Lipoprotein Metabolism by Cultured Human Fibroblasts: Relationship with Aging and Atherosclerosis

1984 • 3 citations

Change in activity of fibroblast mitotic inhibitor from mouse embryo cells aging in vitro and undergoing spontaneous transformation

1980 • 2 citations

Histone acetylation and deacetylation in senescent human diploid fibroblasts

1984 • 2 citations

Newly synthesised DNA in ageing human cells in culture treated with 4-nitroquinoline-1-oxide

1982 • 2 citations

A comparison of protein synthesis between serum deprived and postmitotic human diploid fibroblasts

1982 • 2 citations

Biochemical Studies on Aging Diploid Cells1

2015 • 2 citations

Progressive changes of the growth characteristics of the human diploid cells in serial cultivation in vitro

1970 • 1 citations