Limited lifespan in somatic cell hybrids and cybrids

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants

1964 • 2,108 citations

In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain

1977 • 1,743 citations

Agar suspension culture for the selective assay of cells transformed by polyoma virus

1964 • 1,265 citations

The Interactions of Lectins with Animal Cell Surfaces

1974 • 996 citations

Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium

1974 • 814 citations

Topoinhibition and Serum Requirement of Transformed and Untransformed Cells

1970 • 444 citations

Density Dependent Inhibition of Cell Growth in Culture

1967 • 440 citations

Suppression of malignancy in human cells

1976 • 313 citations

Polyethylene glycol-induced mammalian cell hybridization: Effect of polyethylene glycol molecular weight and concentration

1976 • 300 citations

VARIATION IN THE LIFE-SPAN OF CLONES DERIVED FROM HUMAN DIPLOID CELL STRAINS

1974 • 272 citations

The Cell Biology of Human Aging

1976 • 235 citations

The analysis of malignancy by cell fusion. VII. cytogenetic analysis of hybrids between malignant and diploid cells and of tumours derived from them

1977 • 201 citations

Cytoplasmic transfer of chloramphenicol resistance in human tissue culture cells.

1975 • 165 citations

A preparative method for obtaining enucleated mammalian cells

1975 • 160 citations

Cellular aging--clonal senescence. A review (Part I).

1977 • 105 citations

Nuclear control of cellular aging demonstrated by hybridization of anucleate and whole cultured normal human fibroblasts

1975 • 98 citations

Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential.

1975 • 96 citations

Entry into S phase is inhibited in two immortal cell lines fused to senescent human diploid cells

1979 • 91 citations

Chromosome loss is responsible for segregation at theHPRT locus in Chinese hamster cell hybrids

1977 • 78 citations

Cellular aging studied by the reconstruction of replicating cells from nuclei and cytoplasms isolated from normal human diploid cells

1976 • 75 citations

Staining by Neutral Red and Trypan Blue in Sequence for Assaying Vital and Nonvital Cultured Cells

1973 • 64 citations

Malignancy and Transformation: Expression in Somatic Cell Hybrids and Variants

1977 • 59 citations

Non-linkage of Induced Mutations in Chinese Hamster Cells

1972 • 49 citations

Mutagenesis at the ouabain-resistance locus in human diploid fibroblasts

1977 • 47 citations

Suppression of the transformed phenotype in somatic cell hybrids

1978 • 41 citations

Effect of temperature on the longevity of human fibroblasts in culture

1973 • 40 citations

Evidence for clonal attenuation of growth potential in hela cells

1978 • 40 citations

Tumorigenicity of cells transformed by simian virus 40 and of hybrids between such cells and normal diploid cells

1979 • 40 citations

Noncoordinate expression of SV40-induced transformation and tumorigenicity in mouse cell hybrids

1979 • 38 citations

Attempted hybridizations with senescent human fibroblasts

1973 • 38 citations

Human intraspecific somatic cell hybrids: A genetic and karyotypic analysis of crosses between lymphocytes and D98/AH-2

1975 • 36 citations

The replicative life spans of euploid hybrids derived from short-lived and long-lived human skin fibroblast cultures

1978 • 35 citations

Variation, Senescence, and Neoplasia in Cultured Somatic Cells

1975 • 34 citations

Phenotypic expression of malignancy in hybrid and cybrid mouse cells

1978 • 29 citations

The relationship between transformation and somatic mutation in human and Chinese hamster cells

1978 • 29 citations

The longevity of diploid and polyploid human fibroblasts

1978 • 26 citations

Nucleocytoplasmic interactions in experimental binucleates formed from normal and transformed components

1979 • 24 citations

X-ray dose response for mutation to fructose utilisation in cultured diploid human fibroblasts

1974 • 18 citations

Cybrid formation in mouse L cells: The influence of cytoplast-to-cell ratio

1977 • 17 citations

Regulation of growth and gene activity in euploid hybrids between human neonatal fibroblasts and epithelioid amniotic fluid cells.

1978 • 15 citations

Segregation studies in CHO hybrid cells: I. Spontaneous and mutagen-induced segregation events of two recessive drug-resistant loci

1977 • 15 citations

Growth characteristics in vitro of hybrids between normal and transformed cell lines

1978 • 6 citations

Senescence:Dominant or Recessive in Somatic Cell Crosses

2012 • 5 citations