Restriction enzyme analysis of mitochondrial DNA in aging human cells

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain

1977 • 1,743 citations

Sequence and gene organization of mouse mitochondrial DNA

1981 • 1,712 citations

DNA Methylation Decreases in Aging But Not in Immortal Cells

1983 • 635 citations

The Number of Mitochondrial Deoxyribonucleic Acid Genomes in Mouse L and Human HeLa Cells

1974 • 520 citations

The Absence of a Pyrimidine Dimer Repair Mechanism in Mammalian Mitochondria

1974 • 517 citations

Characterization of a New Human Diploid Cell Strain, IMR-90

1977 • 371 citations

Is Cell Aging Caused by Respiration-Dependent Injury to the Mitochondrial Genome?

1982 • 242 citations

Mitochondrial DNA in mortal and immortal human cells. Genome number, integrity, and methylation.

1983 • 197 citations

Ultrastructural changes accompanying the aging of human diploid cells in culture

1972 • 178 citations

Repair of pyrimidine dimers in nuclear and mitochondrial DNA of yeast irradiated with low doses of ultraviolet light

1975 • 155 citations

Limited lifespan in somatic cell hybrids and cybrids

1980 • 128 citations

Status of mitochondria in living human fibroblasts during growth and senescence in vitro: use of the laser dye rhodamine 123.

1981 • 117 citations

Integration of mitochondrial gene sequences within the nuclear genome during senescence in a fungus

1983 • 107 citations

Recent advances in the cell biology of aging

1980 • 106 citations

Are mitochondrial structural genes selectively amplified during senescence in podospora anserina?

1982 • 104 citations

Maternal inheritance of mitochondrial DNA polymorphisms in cultured human fibroblasts

1981 • 95 citations

Senescence in podospora anserina: Amplification of a mitochondrial DNA sequence

1980 • 93 citations

The fate of ultraviolet-induced pyrimidine dimers in the mitochondrial DNA of Saccharomyces cerevisiae following various post-irradiation cell treatments

1974 • 77 citations

Energy metabolism in cultured human fibroblasts during aging in vitro

1982 • 68 citations

The initiation of transcription of sv40 DNA at late time after infection

1979 • 52 citations

Fine structure of IMR-90 cells in culture as examined by scanning and transmission electron microscopy

1979 • 48 citations

Quantitation of Mitochondrial Dna and Protein in the Liver of Fischer 344 Rats During Aging

1978 • 47 citations

Selective nicking of mammalian mitochondrial DNA in vivo: Photosensitization by incorporation of 5-bromodeoxyuridine

1975 • 45 citations

Lowered rates of protein synthesis by mitochondria isolated from organisms of increasing age

1984 • 41 citations

High-voltage electron microscopy of human diploid fibroblasts during ageing in vitro *1Morphometric analysis of mitochondria

1984 • 39 citations

Mitochondrial protein synthesis in mouse L-cells: Effect of selective nicking of mitochondrial DNA

1975 • 37 citations

Complex forms and replicative intermediates of mitochondrial DNA in tissues from adult and senescent mice

1977 • 33 citations

Quantification of mitochondria during the cell cycle of Chinese hamster cells

1976 • 31 citations

DNA sequence of the excision sites of a mitochondrial plasmid from senescentPodospora anserina

1983 • 26 citations

Cloning of mouse mitochondrial DNA in E. coli affects bacterial viability

1980 • 24 citations

Loss of mitochondrial DNA with aging in the Swedish C strain of Drosophila melanogaster

1981 • 22 citations

The molecular biology of the mitochondrion

1982 • 20 citations

Does mitochondrial ATP synthesis decline as a function of change in the membrane environment with ageing

1983 • 17 citations

Structural and replicative forms of mitochondrial DNA from human leukocytes in relation to age

1978 • 15 citations

Changes in mitochondrial DNA during aging

1982 • 11 citations

Effect of mitochondrial DNA composition on the cellular properties of interspecific hybrid cells

1983 • 9 citations

Identification of a mitochondrial endonuclease involved in mt-DNA repair of Saccharomyces cerevisiae

1984 • 4 citations

Clofibrate effects: Mitochondria vs exercise tolerance in aging hamsters

1977 • 1 citations