Aging dependent nucleolar and chromatin changes in cultivated fibroblasts

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1956 • 14,202 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

1970 • 1,002 citations

The relationship between in vitro cellular aging and in vivo human age.

1976 • 559 citations

MORPHOLOGICAL STUDIES OF TRANSCRIPTION

1972 • 378 citations

A retarded rate of DNA replication and normal level of DNA repair in Werner's syndrome fibroblasts in culture

1977 • 161 citations

LIFESPAN OF CULTURED CELLS IN PROGERIA

1969 • 149 citations

Premature ageing and occurrance of altered enzyme in Werner's syndrome fibroblasts

1974 • 100 citations

Comparative ultrastructure of chick fibroblasts in vitro at early and late stages during their growth span

1971 • 82 citations

Altered rate of DNA replication in ageing human fibroblast cultures

1974 • 80 citations

ANALOGY IN GROWTH BETWEEN LATE PASSAGE HUMAN EMBRYONIC AND EARLY PASSAGE HUMAN ADULT FIBROBLASTS

1969 • 76 citations

Alteration of fibroblast gene products in vitro from a subject with Werner's syndrome

1974 • 56 citations

New aspects of intranuclear structures following partial decondensation of chromatin: a cytochemical and high-resolution autoradiographical study

1980 • 47 citations

Visualization of two different types of nuclear transcriptional complexes in rat liver cells

1977 • 41 citations

Relationship between chromatin and perichromatin granules in cadmium-treated isolated hepatocytes

1981 • 40 citations

Deteriorating collagen synthesis and cell ultrastructure accompanying senescence of human normal and Werner's syndrome fibroblast cell strains

1979 • 36 citations

Effect of low dose rate irradiation on the division potential of cells in vitro. VI. Changes in DNA and in radiosensitivity during aging of human fibroblasts

1979 • 31 citations

Effect of low dose rate irradiation on the division potential of cells in vitro. IV. Embryonic and adult human lung fibroblast-like cells

1978 • 29 citations

Ultrastructural organization of nucleoproteins during aging of cultured human embryonic fibroblasts

1982 • 26 citations

Cell-surface changes accompanying aging in human diploid fibroblasts: Effects of tissue, donor age and genotype

1980 • 20 citations

Comparison between proliferative changes and nuclear events during ageing of human fibrobalsts in vitro

1982 • 19 citations

Comparison of Ageing <i>in vitro </i>and Ageing <i>in vivo </i>by Means of Cell Size Analysis Using a Coulter Counter

1970 • 17 citations

Transcription in early and late passage embryonic mouse fibroblasts in primary culture: A correlated biochemical, autoradiographical and ultrastructural study

1978 • 10 citations

Phénotypes des fibroblastes d'embryons de souris vieillissant in vitro (sem et tem)

1979 • 5 citations

Determination of the nuclear RNA content of cells from donors of three different ages during in vitro senescence

1981 • 4 citations

Nih gerontology research support: Policy evaluation of in vitro cell lineage studies☆

1975 • 2 citations