Survival and Growth Requirements of Nontransformed Cells

Trace Elements in Human and Animal Nutrition

1963 • 4,642 citations

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

1975 • 4,443 citations

Amino Acid Metabolism in Mammalian Cell Cultures

1959 • 4,025 citations

Epidermal Growth Factor

1979 • 2,964 citations

Calmodulin Plays a Pivotal Role in Cellular Regulation

1980 • 2,441 citations

Role of cell shape in growth control

1978 • 2,434 citations

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

1979 • 2,285 citations

A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro

1974 • 1,838 citations

Calcium regulation of growth and differentiation of mouse epidermal cells in culture

1980 • 1,810 citations

Nutrition Needs of Mammalian Cells in Tissue Culture

1955 • 1,562 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Fibronectins—adhesive glycoproteins of cell surface and blood

1978 • 1,418 citations

Polyamines in rapid growth and cancer

1978 • 1,354 citations

Agar suspension culture for the selective assay of cells transformed by polyoma virus

1964 • 1,265 citations

1,4-Diaminobutane (Putrescine), Spermidine, and Spermine

1976 • 1,203 citations

Control of proliferation in animal cells

1974 • 1,177 citations

CLONAL GROWTH OF MAMMALIAN CELLS IN VITRO

1956 • 1,130 citations

Nutrition of Animal Cells in Tissue Culture. I. Initial Studies on a Synthetic Medium.,

1950 • 1,066 citations

Methods for growth of cultured cells in serum-free medium

1980 • 1,013 citations

Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium

1952 • 1,001 citations

Trace Elements in Human and Animal Nutrition

1956 • 981 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

An improved nutrient solution for diploid Chinese hamster and human cell lines

1963 • 890 citations

Relationships between calcium and cyclic nucleotides in cell activation.

1977 • 849 citations

Production of Malignancy in Vitro. IV. The Mouse Fibroblast Cultures and Changes Seen in the Living Cells

1943 • 843 citations

Somatomedin: Proposed Designation for Sulphation Factor

1972 • 840 citations

CLONAL GROWTH OF MAMMALIAN CELLS IN A CHEMICALLY DEFINED, SYNTHETIC MEDIUM

1965 • 833 citations

Cellular Adhesiveness and Extracellular Substrata

1978 • 829 citations

Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium

1974 • 814 citations

Primary culture of parenchymal liver cells on collagen membranes

1975 • 808 citations

The initiation of cell division in a contact‐inhibited mammalian cell line

1965 • 807 citations

Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth

1974 • 786 citations

Isolation and structure of urogastrone and its relationship to epidermal growth factor

1975 • 751 citations

An endothelial cell growth factor from bovine hypothalamus: identification and partial characterization.

1979 • 727 citations

Induction of DNA synthesis in BALB/c 3T3 cells by serum components: Reevaluation of the commitment process

1977 • 695 citations

The platelet-derived growth factor

1978 • 649 citations

Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes

1977 • 641 citations

A RAPID METHOD FOR VIABLE CELL TITRATION AND CLONE PRODUCTION WITH HELA CELLS IN TISSUE CULTURE: THE USE OF X-IRRADIATED CELLS TO SUPPLY CONDITIONING FACTORS

1955 • 637 citations

Platelets as a source of fibroblast growth-promoting activity

1974 • 625 citations

The Growth in Vitro of Single Isolated Tissue Cells

1948 • 593 citations

Biochemical actions of hormones

1987 • 588 citations

Purification of human platelet-derived growth factor.

1979 • 586 citations

Control of growth of mammalian cells in cell culture

1975 • 547 citations

"Contact inhibition" of cell division in 3T3 cells.

1968 • 547 citations

Anchorage and growth regulation in normal and virus‐transformed cells

1968 • 547 citations

Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes.

1978 • 535 citations

Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors

1979 • 517 citations

Determination of cellular shape by the extracellular matrix and its correlation with the control of cellular growth.

1978 • 487 citations

Growth Factors in Mammalian Cell Culture

1976 • 483 citations

Cyclic AMP in relation to proliferation of the Epidermal cell: a new view

1978 • 478 citations

An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis

1978 • 472 citations

Growth, Nutrition, and Metabolism of Cells in Culture

1977 • 467 citations

Clonal growth of normal human epidermal keratinocytes in a defined medium

1982 • 442 citations

The influence of collagen on the development of muscle clones.

1966 • 436 citations

The Growth of Cells on a Transparent Gel of Reconstituted Rat-Tail Collagen<xref ref-type="fn" rid="fn1">2</xref>

1956 • 422 citations

THE GROWTH AND MAINTENANCE OF TISSUE–CELL CULTURES IN FREE GAS EXCHANGE WITH THE ATMOSPHERE1

1963 • 417 citations

Replacement of serum by hormones permits growth of cells in a defined medium

1976 • 412 citations

INTERACTIONS OF LIPOSOMES WITH MAMMALIAN CELLS

1978 • 408 citations

Human epidermal growth factor and the proliferation of human fibroblasts

1976 • 403 citations

Pituitary Extracts and Steroid Hormones in the Control of 3T3 Cell Growth

1973 • 387 citations

Toward Molecular Mechanisms of Developmental Processes

1973 • 384 citations

Cell suspensions from organ rudiments of chick embryos

1952 • 383 citations

Increased sodium ion influx is necessary to initiate rat hepatocyte proliferation

1979 • 376 citations

Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle

1979 • 374 citations

Specific binding of phorbol ester tumor promoters

1980 • 364 citations

[5] Media and growth requirements

1979 • 331 citations

[6] The growth of cells in serum-free hormone-supplemented media

1979 • 330 citations

Rapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor.

1979 • 325 citations

Partial replacement of serum by selenite, transferrin, albumin and lecithin in haemopoitec cell cultures

1976 • 319 citations

Growth of Madin-Darby canine kidney epithelial cell (MDCK) line in hormone-supplemented, serum-free medium.

1979 • 306 citations

ADVANCES IN METABOLIC DISORDERS

1965 • 302 citations

Initial adhesion of human fibroblasts in serum-free medium: Possible role of secreted fibronectin

1979 • 299 citations

Chapter 7 Mechanisms of Activation of Sperm and Egg During Fertilization of Sea Urchin Gametes

1978 • 282 citations

Synthesis of labile, serum-dependent protein in early G ₁ controls animal cell growth

1979 • 273 citations

Improved medium for clonal growth of human diploid fibroblasts at low concentrations of serum protein

1977 • 272 citations

REGULATION OF INITIATION OF DNA SYNTHESIS IN CHINESE HAMSTER CELLS

1970 • 271 citations

A platelet factor stimulating human normal glial cells

1976 • 271 citations

The regulation of cell proliferation by calcium and cyclic AMP

1979 • 259 citations

Stimulation of clonal growth of normal fibroblasts with substrata coated with basic polymers.

1976 • 254 citations

Coordinate control of 3T3 cell proliferation by platelet-derived growth factor and plasma components.

1978 • 252 citations

Adhesion among neural cells of the chick embryo. IV. Role of the cell surface molecule CAM in the formation of neurite bundles in cultures of spinal ganglia.

1978 • 250 citations

Selenium is an essential trace nutrient for growth of WI-38 diploid human fibroblasts.

1976 • 243 citations

Multiplication and division in mammalian cells

1976 • 242 citations

Correlation of patterns of anchorage-independent growth with in vivo behavior of cells from a murine fibrosarcoma.

1980 • 242 citations

Neoplasia: a disease of cell differentiation.

1968 • 241 citations

Reproduction of Eukaryotic Cells

1976 • 235 citations

Calcium as a Regulator of the Proliferation of Normal, but Not of Transformed, Chicken Fibroblasts in a Plasma-Containing Medium

1971 • 230 citations

Clonal growth of human keratinocytes with small amounts of dialyzed serum

1980 • 224 citations

The positive control of cell proliferation by the interplay of calcium ions and cyclic nucleotides. A review

1976 • 219 citations

Mammalian cell cycles need two random transitions

1980 • 215 citations

Multiplication and Division in Mammalian Cells

1977 • 212 citations

Vasopressin stimulation of mouse 3T3 cell growth.

1979 • 210 citations

Stimulation of DNA synthesis by tumour promoter and pure mitogenic factors

1978 • 207 citations

The Utilization of Carbohydrates by Human Cell Cultures

1958 • 206 citations

THE POPULATION-DEPENDENT REQUIREMENT BY CULTURED MAMMALIAN CELLS FOR METABOLITES WHICH THEY CAN SYNTHESIZE

1962 • 204 citations

Human epidermal cell cultures: growth and differentiation in the absence of differentiation in the absence of dermal components or medium supplements.

1979 • 204 citations

Induction of Mitosis in Mature Neurons in Central Nervous System by Sustained Depolarization

1976 • 203 citations

Central role for magnesium in coordinate control of metabolism and growth in animal cells.

1975 • 202 citations

Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2alpha.

1975 • 196 citations

Role of Selenium in The Chemoprevention of Cancer

1979 • 193 citations

Selenium in Biology

1975 • 192 citations

Loss of Division Potential in Vitro: Aging or Differentiation?

1978 • 189 citations

Control of the Initiation of DNA Synthesis in 3T3 Cells: Serum Factors

1974 • 184 citations

Multiplication‐stimulating activity for chicken embryo fibroblasts from rat liver cell conditioned medium: A family of small polypeptides

1973 • 181 citations

Substrate properties influencing ultrastructural differentiation of mammary epithelial cells in culture

1979 • 181 citations

MOLECULAR GROWTH REQUIREMENTS OF SINGLE MAMMALIAN CELLS: THE ACTION OF FETUIN IN PROMOTING CELL ATTACHMENT TO GLASS

1958 • 181 citations

Interruption of the adipose conversion of 3T3 cells by biotin deficiency: differentiation without triglyceride accumulation

1978 • 176 citations

Osmolality of mammalian blood and of media for culture of mammalian cells

1970 • 175 citations

Growth of a human mammary tumour cell line in a serum-free medium

1979 • 174 citations

Mediation of pinocytosis in cultured arterial smooth muscle and endothelial cells by platelet-derived growth factor

1978 • 171 citations

Calcium, magnesium, and growth control in the WI-38 human fibroblast cell.

1979 • 170 citations

Cellular tumorigenicity in nude mice. Test of associations among loss of cell-surface fibronectin, anchorage independence, and tumor-forming ability.

1979 • 170 citations

Control of the Initiation of DNA Synthesis in 3T3 Cells: Low-Molecular-Weight Nutrients

1974 • 170 citations

Growth and differentiation of human keratinocytes without a feeder layer or conditioned medium

1980 • 159 citations

lipid Metabolism in Tissue Culture Cells

1967 • 159 citations

Growth of functional primary cultures of kidney epithelial cells in defined medium

1980 • 159 citations

Lipid metabolism in cultured cells

1966 • 158 citations

[9] Quantitative colonial growth of isolated mammalian cells

1962 • 156 citations

Fibronectin mediates cytokinesis and growth of rat follicular cells in serum-free medium

1979 • 156 citations

Induction of growth in resting fibroblastic cell cultures by Ca++.

1975 • 154 citations

The effect of oxygen tension on the growth and metabolism of WI‐38 cells

1976 • 151 citations

Serum Factor Requirements of Normal and Simian Virus 40-Transformed 3T3 Mouse Fibroblasts

1971 • 151 citations

Adhesion among neural cells of the chick embryo.

1977 • 151 citations

Density dependent proliferation of human glia cells stimulated by epidermal growth factor

1976 • 150 citations

Binding and Uptake of Transcobalamin II by Human Fibroblasts

1978 • 148 citations

Malignant Hemangioendotheliomas Produced by Subcutaneous Inoculation of Balb/3T3 Cells Attached to Glass Beads

1975 • 140 citations

Cytotoxicity of ascorbate and other reducing agents towards cultured fibroblasts as a result of hydrogen peroxide formation

1977 • 140 citations

Rapid clonal growth and serial passage of human diploid fibroblasts in a lipid-enriched synthetic medium supplemented with epidermal growth factor, insulin, and dexamethasone.

1981 • 139 citations

Different calcium requirements for proliferation of conditionally and unconditionally tumorigenic mouse cells.

1976 • 138 citations

Transforming viruses directly reduce the cellular growth requirement for a platelet derived growth factor

1978 • 134 citations

Putrescine and related amines as growth factors for a mammalian cell line

1963 • 134 citations

Requirements for Growth of Single Human Cells

1959 • 133 citations

Improved medium and culture conditions for clonal growth with minimal serum protein and for enhanced serum-free survival of Swiss 3T3 cells

1981 • 132 citations

Chapter 4 Lipid Vesicles as Carriers for Introducing Biologically Active Materials into Cells

1976 • 131 citations

Biochemistry of Cultured Mammalian Cells

1961 • 130 citations

The use of hormone-supplemented serum-free media in primary cultures

1979 • 130 citations

Physiological quiescence in plasma‐derived serum: Influence of platelet‐derived growth factor on cell growth in culture

1978 • 129 citations

Identification of hydrogen peroxide as a photoproduct toxic to human cells in tissue-culture medium irradiated with “daylight” fluorescent light

1978 • 128 citations

The control of human WI‐38 cell proliferation by extracellular calcium and its elimination by SV‐40 virus‐induced proliferative transformation

1977 • 126 citations

Clonal growth of Chinese hamster cell lines in protein-free media

1977 • 126 citations

Action of growth factors in the cell cycle

1979 • 125 citations

Lipid Metabolism in Tissue Culture Cells1 1This investigation was supported in part by Public Health Service Research Grant 5-RO1-HE 09103 from the National Heart Institute and Public Health Service Research Fellowship 5-F3-AM-34, 974 from the National Institute of Arthritis and Metabolic Diseases.

1969 • 123 citations

The requirement for L-asparagine of mouse leukemia cells L5178Y in culture.

1961 • 119 citations

THE ROLE OF SERUM IN THE CONTROL OF MULTIPLICATION OF AVIAN AND MAMMALIAN CELLS IN CULTURE

1972 • 118 citations

Loss of epidermal growth factor requirement and malignant transformation

1979 • 117 citations

Retrodifferentiation and the Fetal Patterns of Gene Expression in Cancer

1979 • 117 citations

The localization of trypsin in cultured mammalian cells

1973 • 115 citations

Control of the Balb/c‐3T3 cell cycle by nutrients and serum factors: Analysis using platelet‐derived growth factor and platelet‐poor plasma

1979 • 114 citations

Identification of an adhesion factor for chondrocytes.

1980 • 114 citations

Induction of human fibroblast proliferation by epidermal growth factor (EGF): enhancement by an EGF-binding arginine esterase and by ascorbate.

1976 • 110 citations

Centriole deciliation associated with the early response of 3T3 cells to growth factors but not to SV40

1979 • 110 citations

The roles of the polyamines, putrescine, spermidine, and spermine in normal and malignant tissues

1973 • 109 citations

The potassium-sensitivity of isolated embryonic heart cells increases with development

1970 • 107 citations

Exponential 3T3 cells escape in mid-G1 from their high serum requirement

1978 • 104 citations

The tumor promoter 12‐0‐tetradecanoyl‐phorbol‐13‐acetate enhances the proliferative response of Balb/c‐3T3 cells to hormonal growth factors

1979 • 103 citations

Identification of a Growth Factor produced by Human Fibroblasts in vitro as Putrescine

1972 • 103 citations

Growth stimulation of human diploid fibro‐blasts by the tumor promoter, 12‐0‐tetradecanoyl‐phorbol‐13‐acetate

1974 • 101 citations

Reproduction of eukaryotic cells

1977 • 99 citations

Iron salts and transferrin are specifically required for cell division of cultured 3T6 cells

1977 • 98 citations

Development of improved media and culture conditions for clonal growth of normal diploid cells

1978 • 97 citations

Extension of the Lifespan of Cultured Normal Human Diploid Cells by Vitamin E

1974 • 96 citations

Calcium and magnesium ions and the regulation of multiplication in normal and transformed cells

1978 • 96 citations

Growth and differentiation of embryonal carcinoma cell line F9 in defined media.

1980 • 95 citations

Human vitamin B12 transport proteins.

1975 • 94 citations

Fibronectin: a chromatin-associated protein?

1979 • 94 citations

The Preparation and Handling of Replicate Tissue Cultures for Quantitative Studies

1951 • 94 citations

Lipid requirement for cell cycling

1977 • 93 citations

Growth of embryonal carcinoma cells in serum-free medium.

1978 • 93 citations

The effect of temperature during trypsin treatment on viability and multiplication potential of single normal human and chicken fibroblasts

1977 • 93 citations

Effect of room fluorescent light on the deterioration of tissue culture medium

1976 • 93 citations

Stimulation of esterified cholesterol accumulation in tissue culture cells exposed to high density lipoproteins enriched in free cholesterol.

1978 • 92 citations

Toxicity, radiation sensitivity modification, and metabolic effects of dehydroascorbate and ascorbate in mammalian cells,

1978 • 91 citations

Calcium‐dependent stimulation of BALB/c 3T3 mouse cell DNA synthesis by a tumor‐promoting phorbol ester (PMA)

1976 • 88 citations

Polyunsaturated fatty acids, vitamine E, and the proliferation of aortic smooth muscle cells

1979 • 88 citations

The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro.

1977 • 86 citations

[20] Cell synchronization

1979 • 86 citations

The Role of Serum in Cell Culture

1975 • 84 citations

OBSERVATIONS ON THE EFFECTS OF INSULIN INTRODUCED INTO THE MEDIUM OF TISSUE CULTURES

1924 • 83 citations

AN IMPROVED CHEMICALLY DEFINED BASAL MEDIUM (CMRL-1415) FOR NEWLY EXPLANTED MOUSE EMBRYO CELLS

1966 • 81 citations

Phosphoethanolamine as a growth factor of a mammary carcinoma cell line of rat.

1979 • 81 citations

Magnesium deprivation reproduces the coordinate effects of serum removal or cortisol addition on transport and metabolism in chick embryo fibroblasts

1976 • 81 citations

Evolution and Function of Calcium-Binding Proteins

1976 • 80 citations

Immunologic detection of retina cognin on the surface of embryonic cells

1979 • 79 citations

Basic Bacteriology: Its Biological and Chemical Background

1966 • 79 citations

Nutritional requirements of primary cultures a neglected problem of modern biology

1974 • 79 citations

Assay and partial purification of factors from serum that control multiplication of human diploid fibroblasts

1978 • 78 citations

Chapter 9 Normal Human Prostate Epithelial Cell Cultures

1980 • 78 citations

A saturable high affinity binding site for transcobalamin II-vitamin B12 complexes in human placental membrane preparations.

1977 • 76 citations

Isolation and characterization of a siderophore-like growth factor from mutants of SV40-transformed cells adapted to picolinic acid

1978 • 74 citations

Growth-Promoting Properties of Pyruvate, Oxalacetate, and -Ketoglutarate For Isolated Walker Carcinosarcoma 256 Cells

1958 • 72 citations

Nutritional Requirements of Cultured Cells

1979 • 72 citations

Stimulation of the Clonal Growth and Differentiation of Feeder Layer Dependent Mouse Embryonal Carcinoma Cells by β-Mercaptoethanol

1978 • 71 citations

The Growth Requirements of Vertebrate Cells in Vitro

1982 • 69 citations

Growth control in cultured 3T3 fibroblasts. Assays of cell proliferation and demonstration of a growth inhibitory activity.

1979 • 68 citations

MITOTIC AND NONMITOTIC MULTIPLE-LAYERED PERFUSION CULTURES

1969 • 68 citations

Defined Media and the Determination of Nutritional and Hormonal Requirements of Mammalian Cells in Culture

2009 • 67 citations

Mutual potentiation by magnesium and calcium of growth in animal cells.

1976 • 67 citations

Determination of L-ascorbic acid levels in culture medium: Concentrations in commercial media and maintenance of levels under conditions of organ culture

1977 • 65 citations

[21] New Techniques for Culturing Differential Cells: Reconstituted basement membrane rafts

1979 • 65 citations

Platelet-derived growth factor prevents G0 growth arrest

1979 • 63 citations

The Nutrition of Animal Cells

1954 • 63 citations

Melanoma cells which require cyclic AMP for growth

1975 • 62 citations

ASCORBIC ACID AND COLLAGEN SYNTHESIS IN CULTURED FIBROBLASTS

1975 • 62 citations

Major intracellular cations and growth control: Correspondence among magnesium content, protein synthesis, and the onset of DNA synthesis in BALB/c3T3 cells

1979 • 60 citations

Nutritional requirements for growth of a mouse lymphoma in cell culture

1960 • 58 citations

Feeder layer and nutritional requirements for the establishment and cloning of human malignant lymphoma cell lines.

1979 • 58 citations

Neural regulatory mechanisms during aging

1981 • 57 citations

Multiplication of human diploid fibroblasts in a synthetic medium supplemented with EGF, insulin, and dexamethasone

1981 • 56 citations

Chapter 1: Cultivation of Cells in Protein-and Lipid-Free Synthetic Media

1973 • 56 citations

Essential fatty acid requirements of cells in tissue culture: A review

1973 • 56 citations

Cultivation of Animal Cells in Chemically Defined Media, A Review

1973 • 55 citations

Reduction of the calcium requirement of normal human epithelial cells by EGF

1979 • 55 citations

Bromodeoxyuridine Dependence—A New Mutation in Mammalian Cells

1973 • 54 citations

Cholera toxin stimulates division of 3T3 cells

1979 • 53 citations

The mitogenic effect of A23187 in human peripheral lymphocytes

1977 • 53 citations

Die Bedeutung der Aminosäuren für die Gewebezellen in vitro^1,2

1941 • 53 citations

The cyclic AMP‐dependent initiation of DNA synthesis by T51B rat liver epithelioid cells

1979 • 53 citations

Transport of Folate Compounds in Bacterial and Mammalian Cells

1979 • 52 citations

Different survival of normal and transformed cells exposed to nutritional conditions nonpermissive for growth.

1977 • 52 citations

Replacement of serum in cell culture by hormones: A study of hormonal regulation of cell growth and specific gene expression

1978 • 51 citations

Extension of the lifespan of cultured normal human diploid cells by vitamin E: a reevaluation.

1977 • 51 citations

Modulation of Cell Behavior In Vitro by the Substratum in Fibroblastic and Leukemic Mouse Cell Lines

1972 • 51 citations

Cyclic amp, prostaglandins, and the control of cell proliferation

1974 • 51 citations

Complexes of inorganic pyrophosphate, orthophosphate, and calcium as stimulants of 3T3 cell multiplication

1977 • 51 citations

Stimulation of DNA synthesis and cell division in a chemically defined medium: Effect of Epidermal Growth Factor, Insulin and Vitamin B12 on resting cultures of 3T6 cells

1976 • 49 citations

MOLECULAR CONTROL OF PROLIFERATION AND DIFFERENTIATION

1978 • 49 citations

Optimal conditions for the study of growth control in BALB/c 3T3 fibroblasts

1975 • 48 citations

Evidence suggesting that a cyclic AMP‐dependent protein kinase is a positive regulator of proliferation in Cloudman S91 melanoma cells

1979 • 48 citations

Oxocarboxylic acids, pyridine nucleotide‐linked oxidoreductases and serum factors in regulation of cell proliferation

1979 • 48 citations

Early cellular responses to diverse growth stimuli independent of protein and RNA synthesis

1975 • 48 citations

The role of serum and fetuin in the growth of monkey kidney cells in culture

1969 • 47 citations

Role of fatty acids in growth‐promoting effect of serum albumin on hamster cells in vitro

1978 • 47 citations

Kinetics of gas diffusion in mammalian cell culture systems. I. Experimental

1968 • 47 citations

Induction by lithium ion of multiplication of mouse mammary epithelium in culture.

1979 • 46 citations

Purification of a serum protein required by a mammalian cell in tissue culture

1957 • 46 citations

Local starvation for epidermal growth factor cannot explain density-dependent inhibition of normal human glial cells.

1977 • 46 citations

Fibroblast growth factor can substitute for platelet factor to sustain the growth of BALB/3T3 cells in the presence of plasma

1975 • 45 citations

Serum requirements for survival of 3T3 and SV3T3 fibroblasts

1972 • 45 citations

Nonspecific nature of the stimulus to DNA synthesis in cultures of chick embryo cells.

1975 • 45 citations

Construction and Use of Synthetic Media

1965 • 44 citations

Biochemical selection systems for mammalian cells: The essential amino acids

1976 • 44 citations

Clonal growth of diploid Chinese hamster cells in a synthetic medium supplemented with purified protein fractions

1962 • 43 citations

THE GASEOUS ENVIRONMENT OF THE MAMMALIAN CELL IN CULTURE

1972 • 43 citations

Stimulation of sugar uptake and thymidine incorporation in mouse 3T3 cells by calcium phosphate and other extracellular particles.

1977 • 43 citations

Differences in growth response to hydrocortisone and ascorbic acid by human diploid fibroblasts

1977 • 42 citations

Ascorbic Acid: A Culture Requirement for Colony Formation by Mouse Plasmacytoma Cells

1971 • 41 citations

Epidermal growth factor modulates extracellular Ca2+ requirement for multiplication of normal human skin fibroblasts

1979 • 41 citations

FATTY ACID, GLYCERIDE, AND PHOSPHOLIPID METABOLISM

1972 • 41 citations

Suppression of dysplasia and hyperplasia by calcium in organ-cultured urinary bladder epithelium.

1978 • 40 citations

Nature of the iron requirement for Chinese hamster V79 cells in tissue culture medium

1973 • 40 citations

The supply of oxygen to submerged cultures of BHK 21 cells

1972 • 40 citations

CONSTRUCTION OF TISSUE CULTURE MEDIA

1972 • 39 citations

The different actions of normal and supranormal calcium concentrations on the proliferation of BALB/c 3T3 mouse cells

1976 • 39 citations

Proliferation of Rous sarcoma virus-infected, but not of normal, chicken fibroblasts in a medium of reduced calcium and magnesium concentration

1979 • 39 citations

Application of the principles of enzyme kinetics to clonal growth rate assays: An approach for delineating interactions among growth promoting agents

1979 • 38 citations

Improvements in a chemically defined medium for the growth of mouse cells (strain LS) in suspension

1970 • 37 citations

TISSUE CULTURE NUTRITION

1958 • 37 citations

Stimulation of DNA synthesis and 2‐deoxy‐D‐glucose transport in chick embryo cultures by excessive metal concentrations and by a carcinogenic hydrocarbon

1973 • 35 citations

Growth control in cultured 3T3 fibroblasts

1982 • 35 citations

Ionic landmarks along the mitogenic route

1979 • 35 citations

The role pf sodium and potassium in regulating amino acid accumulation and protein synthesis in LM-strain mouse fibroblasts

1967 • 34 citations

Cyclic AMP and calcium as intracycle regulators in the control of cell proliferation.

1978 • 34 citations

The growth stimulation of SV3T3 cells by transferrin and its dependence on biotin

1979 • 34 citations

Fractionation and preliminary characterization of a low molecular weight bovine hepatic inhibitor of DNA synthesis in regenerating rat liver

1979 • 34 citations

Effects of depletion of K⁺, Na⁺, or Ca²⁺ on DNA synthesis and cell cation content in chick embryo fibroblasts

1979 • 34 citations

Malignant Transformation in Vitro: Criteria, Biological Markers, and Application in Environmental Screening of Carcinogens

1979 • 33 citations

Trace-Metal Requirements of NCTC Clone 929 Strain L Cells<xref ref-type="fn" rid="FN1">2</xref>

1967 • 32 citations

Amino acid requirements in vitro of human leukemic cells.

1971 • 32 citations

Density-dependent regulation of growth of BSC-1 cells in cell culture: Control of growth by low molecular weight nutrients

1978 • 32 citations

Chapter 2 Cloning of Mammalian Cells

1972 • 32 citations

The effects of biotin and fatty acids on SV3T3 cell growth in the presence of normal calf serum

1977 • 32 citations

Carbohydrate preferences of mammalian cells

1976 • 30 citations

The glucose, insulin and glutamine requirements of suspension cultures of hela cells in a defined culture medium

1971 • 30 citations

An examination of the roles of cyclic nucleotides in the initiation of cell proliferation

1978 • 30 citations

The influence of vitamin E and selenium on the growth and plasma membrane permeability of mouse fibroblasts in culture

1979 • 30 citations

Molecular Control of Proliferation and Differentiation

1978 • 30 citations

Induction of cell division in BALB/c-3T3 cells by phorbol myristate acetate or bovine serum: Effects of inhibitors of cyclic AMP phosphodiesterase and Na+−K+-ATPase

1977 • 27 citations

Vitamin B12 enhances the stimulation of DNA synthesis by serum in resting cultures of 3T6 cells

1977 • 27 citations

Chapter 16 Dermal Fibroblasts

1980 • 27 citations

The Action of Hormones on Cell and Organ Cultures

1965 • 27 citations

The Growth requirements of vertebrate cells in vitro

1981 • 27 citations

Cell saturation density is not determined by a diffusion-limited process

1978 • 26 citations

Plasma and platelet associated factors act in G1 to maintain proliferation and to stabilize arrested cells in a viable quiescent state

1979 • 26 citations

The effect of oleic acid on the growth of monkey kidney cells (LLC-MK2)

1970 • 26 citations

Stimulation of the initiation of DNA synthesis and cell division in several cultured mouse cell types

1979 • 26 citations

Dissociation of ribonucleic acid and protein synthesis in mammalian cells deprived of potassium

1976 • 25 citations

A cell spreading factor in human serum that is not cold-insoluble globulin

1979 • 25 citations

Density-dependent inhibition of fibroblast growth is overcome by pure mitogenic factors

1977 • 24 citations

Vitamin requirements of uterine fibroblasts, strain U12-79; their replacement by related compounds

1958 • 23 citations

Mechanism of Regulation of fibroblastic cell replication. IV. An analysis of the serum dependence of cell replication based on michaelis-menten kinetics

1977 • 23 citations

Cytoplasmic regulation of two G1-specific temperature-sensitive functions

1979 • 23 citations

Role of Photosensitization and Oxygen in Chromosome Stability and “Spontaneous” Malignant Transformation in Culture<xref ref-type="fn" rid="FN2">2</xref>

1979 • 23 citations

Chemically characterized concentrated corodies11Corody, pl. Corodies is defined as “an allowance as of food, provision, aliment, etc.”, here it is used in place of “nutrient media”. for continuous cell culture (the 7C's culture media)

1968 • 22 citations

Cell cycle changes in transformed cells growing under serum‐free conditions

1977 • 22 citations

Polyamines and cellular adenosine 3′ :5′-cyclic monophosphate

1979 • 21 citations

The requirement for biotin in mouse fibroblast L-cells cultured on serumless medium

1969 • 21 citations

Cell cycle regulation by growth factors and nutrients in normal and transformed cells

1978 • 21 citations

The mechanism of regulation of fibroblastic cell replication

1974 • 20 citations

Coordinate control of balb/c3T3 cell survival and multiplication by serum or calcium pyrophosphate complexes

1979 • 20 citations

Failure of Vitamin E to Extend the Life Span of a Human Diploid Cell Line in Culture

1977 • 20 citations

Growth‐modulating human plasma tripeptide: Relationship between molecular structure and DNA synthesis in hepatoma cells

1979 • 19 citations

6,8‐Dihydroxypurine: A novel growth factor for mammalian cells in vitro, isolated from a commercial peptone

1973 • 19 citations

Protein-free medium for C-1300 mouse neuroblastoma cells

1981 • 18 citations

EGF growth promoting activity is neutralized by phorbol esters

1980 • 18 citations

"Serum-free" Culture of Various Mammalian Cells and the Role of Bovine Albumin

1976 • 18 citations

Calcium-Binding Proteins and the Regulation of Contractile Activity

1979 • 16 citations

Growth factors derived from human serum, platelets, and pituitary: properties and immunologic cross-reactivity.

1978 • 16 citations

Keratinocyte substrate adhesion is magnesium-dependent and calcium-independent

1979 • 16 citations

Polyamines as growth stimulating factors in eukariotic cells.

1976 • 15 citations

The concomitant effect of unsaturated fatty acid supplemented to medium on cellular growth and membrane fluidity of cultured cells

1979 • 15 citations

Unique Requirements for Clonal Growth1

1974 • 14 citations

Uptake and utilization of free fatty acids supplied by liposomes to mammary tumor cells in culture

1979 • 14 citations

Comparison of cellular lipids of serum-free strain L mouse fibroblasts

1972 • 13 citations

Regulation of the G₁ → S phase transition in chick embryo fibroblasts with α‐keto acids and L‐alanine

1979 • 12 citations

Amino Acid and Protein Metabolism

1965 • 12 citations

Absence of Essential Fatty Acids in Mammalian Cell Strains Cultured in Lipid- and Protein-Free Chemically Defined Synthetic Media

1970 • 12 citations

On the Role of Calcium in Adhesion of Cells to Solid Substrates

1979 • 10 citations

Siderophore‐like growth factor synthesized by SV40‐transformed cells adapted to picolinic acid stimulates DNA synthesis in cultured cells

1978 • 9 citations

A nutritional test for the low density lipoprotein receptor in chinese hamster fibroblasts

1979 • 9 citations

Growth and G1 arrest of sarcoma virus transformed cells in serum free media

1979 • 9 citations

Growth Control by Serum Factors and Hormones in Mammalian Cells in Culture

1978 • 9 citations

Third Decennial Review Conference: Cell, Tissue and Organ Culture.

1979 • 9 citations

Liver as a source of transformed cell growth factor

1979 • 9 citations

Trace element uptake by L‐cells as a function of trace elements in a synthetic growth medium

1979 • 8 citations

Fixation spontanée de la biotine à une protéine dans le Sérum humain

1965 • 8 citations

Reactivation of G nuclei by S-phase cells

1980 • 8 citations

Some <italic>In Vitro</italic> Requirements of Cells of C3H Mouse, Chinese Hamster, Green Monkey, and Human Origin

1966 • 7 citations

Cell density is determined by a diffusion-limited process (reply)

1979 • 6 citations

Effects of Basic Polymers on Growth of Tumor Cells in Suspension Cultures with "Serum-free" Medium

1976 • 6 citations

Growth limitation of BHK-21 cells and its relation to folate metabolism

1979 • 5 citations

Nutrition of cells in culture--a review.

1967 • 5 citations

Density-Dependent Growth Adaptation Kinetics in 3T 3 Cell Populations Following Sudden [Ca2+] and Temperature Changes. A Comparison with SV40-3T3 Cells

1979 • 5 citations

Pyrimidine Nucleoside Requirements of a Neoplastic C3H Mouse Cell Strain

1967 • 4 citations

Some Aspects of the Role of Vitamin B<sub>12</sub> and Folic Acid in DNA-Thymidine Synthesis in a Neoplastic C3H Mouse Cell Strain

1971 • 4 citations

5-Methyltetrahydrofolic acid, 5-formyltetrahydrofolic acid (folinic acid), and folic acid requirements of normal and Rous sarcoma virus-infected chicken fibroblasts.

1978 • 2 citations

Deleted Work

1955 • 0 citations