Evidence that a critical threshold of DNA polymerase‐alpha activity may be required for the initiation of DNA synthesis in mammalian cell heterokaryons

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

MATHEMATICAL ANALYSIS OF DNA DISTRIBUTIONS DERIVED FROM FLOW MICROFLUOROMETRY

1974 • 795 citations

Multienzyme complex for metabolic channeling in mammalian DNA replication.

1980 • 349 citations

Replication of Eukaryotic Chromosomes: A Close-up of the Replication Fork

1980 • 330 citations

T98G: An anchorage‐independent human tumor cell line that exhibits stationary phase G1 arrest in vitro

1979 • 304 citations

Preparation of tissues for DNA flow cytometric analysis

1980 • 231 citations

Involvement of DNA polymerase alpha in simian virus 40 DNA replication.

1978 • 214 citations

The interrelation between DNA synthesis and various DNA polymerase activities in synchronized HeLa cells

1974 • 195 citations

Dominance of the Senescent Phenotype in Heterokaryons Between Replicative and Post-Replicative Human Fibroblast-Like Cells

1974 • 157 citations

Nuclear DNA polymerases and the HeLa cell cycle.

1975 • 152 citations

Diadenosine 5',5'''-P1,P4-tetraphosphate, a ligand of the 57-kilodalton subunit of DNA polymerase alpha.

1979 • 149 citations

HeLa cell DNA polymerase .gamma.: further purification and properties of the enzyme

1976 • 147 citations

Decreased fidelity of DNA polymerase activity isolated from aging human fibroblasts.

1976 • 132 citations

HeLa cell DNA polymerase alpha is tightly associated with tryptophanyl-tRNA synthetase and diadenosine 5',5"'-P1,P4-tetraphosphate binding activities.

1981 • 99 citations

Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential.

1975 • 96 citations

Comparative heterokaryon study of cellular senescence and the serum-deprived state

1980 • 92 citations

Entry into S phase is inhibited in two immortal cell lines fused to senescent human diploid cells

1979 • 91 citations

Accessory proteins for DNA polymerase alpha activity with single-strand DNA templates.

1981 • 91 citations

Life histories of hyperplastoid cell lines from aorta and skin

1973 • 86 citations

Enhancement of Rhinovirus Plaque Formation in Human Heteroploid Cell Cultures by Magnesium and Calcium

1966 • 76 citations

Cellular Aging in Werner's Syndrome: A Unique Phenotype?

1979 • 72 citations

Mechanism and Regulation of DNA Replication

1974 • 70 citations

Serological Comparison of Ten GlycolyticMycoplasmaSpecies

1969 • 69 citations

REGULATION OF INITIATION OF DNA REPLICATION

1979 • 68 citations

Increased error frequency of DNA polymerases from senescent human fibroblasts

1981 • 64 citations

Distinctive properties of mammalian DNA polymerases

1979 • 60 citations

Evidence for endogenous polypeptide-mediated inhibition of cell-cycle transit in human diploid cells.

1982 • 57 citations

Changes in DNA polymerases .alpha., .beta., and .gamma. during the replicative life span of cultured human fibroblasts

1982 • 48 citations

Altered nuclear deoxyribonucleic acid α-polymerases in senescent cultured chick embryo fibroblasts

1976 • 41 citations

DNA polymerase-alpha. Common polypeptide core structure of three enzyme forms from human KB cells.

1982 • 38 citations

Properties of DNA polymerases from young and ageing human fibroblasts

1981 • 31 citations

Diadenosine Tetraphosphate Triggers In Vitro DNA Replication

1979 • 22 citations

The Three DNA Polymerases of Animal Cells: Properties and Functions

1978 • 21 citations

The DNA polymerases of Chinese hamster cells

1975 • 20 citations

The Separate Roles of Nucleus and Cytoplasm in the Synthesis of DNA

1960 • 14 citations

DNA synthesis of sublethally injured cells in heterokaryons and its relevance to clonal senescence

1979 • 14 citations

Dna replication in eukaryotes

1978 • 12 citations

Reactivation of chick erythrocyte nuclei in young and senescent WI38 cells

1976 • 12 citations

Complementation in heterokaryons derived from a thymidine kinase deficient cell line and senescent human diploid cells.

1979 • 4 citations