Evidence that transcription changes in ageing cultures are terminal events occuring after the expression of a reduced replicative potential

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1956 • 14,202 citations

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate

1970 • 3,269 citations

The precision of ultraviolet absorption measurements in the Schmidt-Thannhauser procedure for nucleic acid estimation

1962 • 1,066 citations

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

1970 • 1,002 citations

Cellular senescence and DNA synthesis

1973 • 537 citations

STUDIES IN HISTOCHEMISTRY: I. DETERMINATION OF NUCLEIC ACIDS IN MICROGRAM AMOUNTS OF TISSUE

1956 • 330 citations

The division cycle and RNA-synthesis in diploid human cells at different passage levels in vitro

1966 • 271 citations

Ribosomal RNA synthesis in isolated nuclei

1972 • 246 citations

A simple, rapid microassay for DNA

1975 • 227 citations

Transcription of ribonucleic acid in isolated mouse myeloma nuclei

1973 • 209 citations

Control of macromolecular synthesis in proliferating and resting syrian hamster cells in monolayer culture. I. Ribosome function

1971 • 165 citations

Relationship between cell replication and volume in senescent human diploid fibroblasts

1976 • 159 citations

Regulation of the Synthesis and the Stability of Ribosomal RNA during Contact Inhibition of Growth

1971 • 140 citations

Doubling potential, calendar time, and senescence of human diploid cells in culture

1973 • 138 citations

Error Theory and Ageing in Human Diploid Fibroblasts

1972 • 135 citations

The Biology of Aging

1971 • 130 citations

Long-Term Culture of Human Adult Liver Cells: Morphological Changes Related to <i>in vitro</i> Senescence and Effect of Donor’s Age on Growth Potential

1973 • 109 citations

Aging under glass

1970 • 103 citations

Aging of human fibroblasts in vitro

1975 • 93 citations

Alteration in cellular RNAs during the in Vitro lifespan of cultured human diploid fibroblasts

1975 • 78 citations

ANALOGY IN GROWTH BETWEEN LATE PASSAGE HUMAN EMBRYONIC AND EARLY PASSAGE HUMAN ADULT FIBROBLASTS

1969 • 76 citations

Computer Conferencing

1975 • 63 citations

Characterization of fractionated human diploid fibroblast cell populations

1976 • 54 citations

The proportion of cells labeled with tritiated thymidine as a function of population doubling level in cultures of fetal, adult, mutant, and tumor origin

1976 • 54 citations

Chromatin template activity during aging in WI38 cells

1975 • 53 citations

Effects of prolonged quiescence on nuclei and chromatin of WI‐38 fibroblasts

1976 • 49 citations

Changes in enzymic activity during cultivation of human cells in vitro

1973 • 42 citations

SUBCULTIVATIONS, SPLITS, DOUBLINGS, AND GENERATIONS IN CULTURES OF HUMAN DIPLOID FIBROBLASTS

1972 • 37 citations

The Decreased Growth Potential in Vitro of Human Fibroblasts of Adult Origin

1970 • 26 citations

Aging and Cell Division

1975 • 23 citations

Transcriptional activity and chromatin structural changes in a temperature-sensitive mutant of BHK cells blocked in early G1

1976 • 22 citations

Alteration in cellular RNAs during the in vitro lifespan of cultured human diploid fibroblasts II. Synthesis and processing of RNA

1975 • 20 citations

RNA turnover and the growth potential of human cells in culture

1967 • 19 citations

Age-dependent changes in the structure and function of mammalian chromatin—I. Variations in chromatin template activity

1973 • 14 citations

A lack of correlation between decline in growth capacity and nuclear RNA synthesising activity in ageing human embryo cells in culture

1976 • 14 citations

Alterations in Chromatin Functions during Aging in Vitro

1975 • 10 citations

The Establishment of Criteria for ‘Quiescence’ in Ageing Human Embryo Cell Cultures and Their Response to a Proliferative Stimulus

1977 • 10 citations

Alterations in the Ribonucleic Acid Metabolism of Nuclei Isolated from Mouse Fibroblasts during Aging and Growth Restriction in vitro

1976 • 7 citations