Decreased proteolysis and increased amino acid efflux in aging human fibroblasts

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Mammalian Protein Metabolism

1964 • 3,199 citations

Functions of Lysosomes

1966 • 2,942 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

1970 • 1,002 citations

PROTEIN DEGRADATION IN CULTURED CELLS

1974 • 603 citations

KINKING OF THE INTERNAL CAROTID ARTERY

1961 • 431 citations

Ageing of Clones of Mammalian Cells

1973 • 409 citations

Altered Enzymes in Ageing Human Fibroblasts

1972 • 408 citations

MORPHOLOGIC CHANGES ACCOMPANYING SENESCENCE OF CULTURED HUMAN DIPLOID CELLS

1970 • 239 citations

Intracellular protein turnover

1976 • 202 citations

Protein Turnover in Mammalian Cell Cultures

1959 • 200 citations

Protein Degradation in Cultured Cells

1973 • 195 citations

Total human body protein synthesis in relation to protein requirements at various ages

1975 • 188 citations

DIABETES MELLITUS AND AGING: DIMINISHED PLATING EFFICIENCY OF CULTURED HUMAN FIBROBLASTS

1969 • 186 citations

Regulation of Protein Degradation in Mammalian Tissues

1970 • 184 citations

Ultrastructural changes accompanying the aging of human diploid cells in culture

1972 • 178 citations

Relationship between in vivo degradative rates and isoelectric points of proteins.

1975 • 171 citations

LIFESPAN OF CULTURED CELLS IN PROGERIA

1969 • 149 citations

Aging in Cell and Tissue Culture

1970 • 146 citations

Error Theory and Ageing in Human Diploid Fibroblasts

1972 • 135 citations

Selective Degradation of Abnormal Proteins in Mammalian Tissue Culture Cells

1974 • 109 citations

Long-Term Culture of Human Adult Liver Cells: Morphological Changes Related to <i>in vitro</i> Senescence and Effect of Donor’s Age on Growth Potential

1973 • 109 citations

Premature ageing and occurrance of altered enzyme in Werner's syndrome fibroblasts

1974 • 100 citations

Progeria: a cell culture study on aging

1971 • 100 citations

Metabolic Aspects of Aging in Diploid Human Cells

1970 • 88 citations

Alteration in cellular RNAs during the in Vitro lifespan of cultured human diploid fibroblasts

1975 • 78 citations

Heat-Labile Enzymes in Skin Fibroblasts from Subjects with Progeria

1975 • 70 citations

Adenosine 3′:5′-cyclic monophosphate in young and senescent human fibroblasts during growth and stationary phase in vitro. Effects of prostaglandin E1 and of adrenaline

1974 • 59 citations

Heat-labile enzymes in Werner's syndrome fibroblasts

1975 • 57 citations

Alteration of fibroblast gene products in vitro from a subject with Werner's syndrome

1974 • 56 citations

Absence of Detectable HL—A Antigens on Cultured Fibroblasts in Progeria

1973 • 54 citations

Pathological implications of cell aging in vitro

1975 • 43 citations

Increased degradation rates of protein in aging human fibroblasts and in cells treated with an amino acid analog

1976 • 35 citations

Defective Proteins in Normal and Abnormal Human Fibroblasts during Aging in vitro1

2015 • 32 citations

Insulin and protein synthesis in muscle

1970 • 12 citations