Antigen‐specific targeting of CD28‐mediated T cell co‐stimulation using chimeric single‐chain antibody variable fragment‐CD28 receptors

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

1993 • 1,433 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains

1991 • 1,014 citations

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

1987 • 802 citations

Selection of phage antibodies by binding affinity

1992 • 514 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.

1994 • 482 citations

Karnofsky Memorial Lecture. The immunotherapy and gene therapy of cancer.

1992 • 394 citations

In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes.

1995 • 261 citations

Principles for Adoptive T Cell Therapy of Human Viral Diseases

1995 • 256 citations

Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain.

1993 • 242 citations

The ups and downs of T cell costimulation

1994 • 240 citations

Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors.

1993 • 203 citations

The Yin and Yang of T Cell Costimulation

1995 • 180 citations

Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex.

1988 • 180 citations

A reassessment of the role of B7-1 expression in tumor rejection.

1995 • 178 citations

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

1990 • 173 citations

Cure of Xenografted Human Tumors by Bispecific Monoclonal Antibodies and Human T Cells

1994 • 161 citations

The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.

1994 • 145 citations

Idiotypic DNA Vaccines Against B‐cell Lymphoma

1995 • 134 citations

CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells.

1994 • 109 citations

Monomeric homologue of mammalian CD28 is expressed on chicken T cells.

1994 • 69 citations

Cell selection strategies for making antibodies from variable gene libraries: trapping the memory pool

1992 • 54 citations

Delimitation of the proliferative stages in the human thymus indicates that cell expansion occurs before the expression of CD3 (T cell receptor).

1993 • 43 citations