Coupling CD28 Co-Stimulation to Immunoglobulin T-Cell Receptor Molecules: The Dynamics of T-Cell Proliferation and Death

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

1993 • 1,433 citations

Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity.

1989 • 1,350 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

T Cell Affinity Maturation by Selective Expansion during Infection

1999 • 420 citations

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

1991 • 391 citations

Absence of B7-dependent responses in CD28-deficient mice

1994 • 386 citations

Tumor localization of adoptively transferred indium-111 labeled tumor infiltrating lymphocytes in patients with metastatic melanoma.

1989 • 332 citations

A triad of costimulatory molecules synergize to amplify T-cell activation.

1999 • 293 citations

In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes.

1995 • 261 citations

Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain.

1993 • 242 citations

Cancer Patient T Cells Genetically Targeted to Prostate-Specific Membrane Antigen Specifically Lyse Prostate Cancer Cells and Release Cytokines in Response to Prostate-Specific Membrane Antigen

1999 • 229 citations

CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation.

1996 • 220 citations

Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response.

1995 • 220 citations

Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes armed with universal T-cell receptors

1994 • 204 citations

Evolution of a Complex T Cell Receptor Repertoire during Primary and Recall Bacterial Infection

1998 • 202 citations

Cytotoxic T lymphocytes with a grafted recognition specificity for ERBB2-expressing tumor cells.

1994 • 198 citations

The Role of B7-1/B7-2:CD28/CLTA-4 Pathways in the Prevention of Anergy, Induction of Productive Immunity and Down-Regulation of the Immune Response

1996 • 161 citations

In vitro predictors of therapeutic response in melanoma patients receiving tumor-infiltrating lymphocytes and interleukin-2.

1994 • 158 citations

Single chain Ig/gamma gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity.

1996 • 155 citations

The Complexities of T‐Cell Co‐stimulation: CD28 and Beyond

1996 • 148 citations

Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells

1997 • 142 citations

Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice

1989 • 111 citations

Chimeric immunoglobulin-T cell receptor proteins form functional receptors: Implications for T cell receptor complex formation and activation

1990 • 101 citations

The effect of transfection of the CEA gene on the metastatic behavior of the human colorectal cancer cell line MIP-101

1995 • 99 citations

Bypassing immunization: optimized design of "designer T cells" against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA.

1999 • 98 citations

An anti-CD30 chimeric receptor that mediates CD3-zeta-independent T-cell activation against Hodgkin's lymphoma cells in the presence of soluble CD30.

1998 • 97 citations

Cytolysis of tumor cells expressing the Neu/erbB-2, erbB-3, and erbB-4 receptors by genetically targeted naive T lymphocytes.

1996 • 76 citations

Functional management of an antiviral cytotoxic T-cell response

1997 • 64 citations

Qualitative and Quantitative Effects of CD28/B7-Mediated Costimulation on Naive T Cells In Vitro

1998 • 57 citations

Purified MHC Class I and Peptide Complexes Activate Naive CD8+ T Cells Independently of the CD28/B7 and LFA-1/ICAM-1 Costimulatory Interactions

1998 • 50 citations

Isolation and Characterization of an Undifferentiated Human Colon Carcinoma Cell Line (MIP-101)

1987 • 48 citations

Dynamics of Tumor Cell Killing by Human T Lymphocytes Armed With an Anti-Carcinoembryonic Antigen Chimeric Immunoglobulin T-Cell Receptor

2000 • 39 citations

Requirements for Stimulating Naive CD8+ T Cells via Signal 1 Alone

1998 • 38 citations

Imaging pattern of radiolabelled lymphokine-activated killer cells in patients with metastatic malignant melanoma

1991 • 23 citations

Presidential address to the American Association of Immunologists. Stimulating naive T cells.

1999 • 17 citations

Presidential Address to The American Association of Immunologists

1999 • 14 citations

Scintigraphy with In-111 labeled lymphokine-activated killer cells of malignant brain tumor.

1988 • 9 citations