Preparation for a Phase I/II Study Using Autologous Gene Modified T Lymphocytes for Treatment of Metastatic Renal Cancer Patients

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

1985 • 2,616 citations

Renal-Cell Carcinoma

1996 • 2,232 citations

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

1993 • 1,433 citations

Gene Transfer into Humans — Immunotherapy of Patients with Advanced Melanoma, Using Tumor-Infiltrating Lymphocytes Modified by Retroviral Gene Transduction

1990 • 1,307 citations

Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus

1991 • 647 citations

Prospective Randomized Trial of High-Dose Interleukin-2 Alone or in Conjunction With Lymphokine-Activated Killer Cells for the Treatment of Patients With Advanced Cancer

1993 • 639 citations

Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters.

1994 • 586 citations

Delivery of Novel Therapeutic Agents in Tumors: Physiological Barriers and Strategies

1989 • 571 citations

Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors.

1993 • 203 citations

The use of hybrid hybridomas to target human cytotoxic T lymphocytes

1987 • 199 citations

Regression of Advanced Ovarian Carcinoma by Intraperitoneal Treatment With Autologous TLymphocytes Retargeted by a Bispecific Monoclonal Antibody

1995 • 194 citations

Cure of Xenografted Human Tumors by Bispecific Monoclonal Antibodies and Human T Cells

1994 • 161 citations

Single chain Ig/gamma gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity.

1996 • 155 citations

Human gene transfer: characterization of human tumor-infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man.

1990 • 145 citations

Adoptive immunotherapy of ovarian carcinoma with bs-MAb-targeted lymphocytes: a multicenter study.

1992 • 109 citations

Clinical results and characterization of tumor-infiltrating lymphocytes with or without recombinant interleukin 2 in human metastatic renal cell carcinoma.

1991 • 103 citations

Induction of tumor‐cell lysis by bi‐specific monoclonal antibodies recognizing renal‐cell carcinoma and cd3 antigen

1989 • 87 citations

Interferon- α Primed Tumor-Infiltrating Lymphocytes Combined with Interleukin-2 and Interferon- α as Therapy for Metastatic Renal Cell Carcinoma

1993 • 75 citations

Human T-lymphocytes targeted against an established human ovarian carcinoma with a bispecific F(ab')2 antibody prolong host survival in a murine xenograft model.

1991 • 74 citations

Monoclonal antibodies : applications in clinical oncology

1991 • 69 citations

Optimization of culture conditions for activation and large‐scale expansion of human T lymphocytes for bispecific antibody‐directed cellular immunotherapy

1992 • 57 citations

Inhibition of bispecific monoclonal antibody (bsAb)‐targeted cytolysis by human anti‐mouse antibodies in ovarian carcinoma patients treated with bsAb‐targeted activated T‐lymphocytes

1995 • 48 citations

The use of monoclonal antibody G250 in the therapy of renal-cell carcinoma.

1995 • 38 citations

Clustered CD3/TCR complexes do not transduce activation signals after bispecific monoclonal antibody-triggered lysis by cytotoxic T lymphocytes via CD3.

1993 • 31 citations

Genetic correction of cultured T cells from an adenosine deaminase‐deficient patient: Characteristics of non‐transduced and transduced T cells

1992 • 18 citations

Renal cell carcinoma : immunotherapy and cellular biology

1993 • 14 citations