Antigen-dependent CD28 Signaling Selectively Enhances Survival and Proliferation in Genetically Modified Activated Human Primary T Lymphocytes

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Infusions of Donor Leukocytes to Treat Epstein-Barr Virus-Associated Lymphoproliferative Disorders after Allogeneic Bone Marrow Transplantation

1994 • 1,078 citations

Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus

1991 • 647 citations

Adoptive T Cell Therapy of Tumors: Mechanisms Operative in the Recognition and Elimination of Tumor Cells

1991 • 619 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

Tumor antigens recognized by T cells

1997 • 552 citations

Karnofsky Memorial Lecture. The immunotherapy and gene therapy of cancer.

1992 • 394 citations

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.

1995 • 357 citations

Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.

1993 • 341 citations

Monoclonal antibodies to a glycolipid antigen on human neuroblastoma cells.

1985 • 317 citations

Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen).

1985 • 285 citations

Tumor Eradication by Adoptive Transfer of Cytototic T Lymphocytes

1992 • 281 citations

CD28 costimulation prevents cell death during primary T cell activation.

1996 • 270 citations

Receptor-stimulated death pathway is opened by antigen in mature T cells.

1991 • 255 citations

Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle

1993 • 252 citations

Activation-induced death of mature T cells in the regulation of immune responses

1995 • 248 citations

The ups and downs of T cell costimulation

1994 • 240 citations

Upstream-Downstream: CD28 Cosignaling Pathways and T Cell Function

1996 • 229 citations

Induction of anti-self-immunity to cure cancer

1995 • 207 citations

CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response.

1996 • 198 citations

Manipulation of costimulatory signals to enhance antitumor T-cell responses

1995 • 177 citations

Recombinant Retroviruses Pseudotyped With the Vesicular Stomatitis Virus G Glycoprotein Mediate Both Stable Gene Transfer and Pseudotransduction in Human Peripheral Blood Lymphocytes

1997 • 169 citations

T-cell Clonal Anergy

1989 • 163 citations

Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death.

1993 • 152 citations

The Complexities of T‐Cell Co‐stimulation: CD28 and Beyond

1996 • 148 citations

CD28 and apoptosis

1995 • 147 citations

The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.

1994 • 145 citations

Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes.

1989 • 117 citations

CD3‐mediated apoptosis of human medullary thymocytes and activated peripheral T cells: Respective roles of interleukin‐1, interleukin‐2, interferon‐γ and accessory cells

1993 • 113 citations

New strategies for enhancing the immunogenicity of tumors

1993 • 88 citations

Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion

1995 • 74 citations

The Cytoplasmic Domain of CD28 Is both Necessary and Sufficient for Costimulation of Interleukin-2 Secretion and Association with Phosphatidylinositol 3′-Kinase

1994 • 55 citations

Disialoganglioside G_D2 anti‐idiotypic monoclonal antibodies

1993 • 50 citations

GD2 oligosaccharide: target for cytotoxic T lymphocytes.

1995 • 50 citations

The anti-T cell monoclonal antibody 9.3 (Anti-CD28) provides a helper signal and bypasses the need for accessory cells in T Cell activation with immobilized anti-CD3 and mitogens

1989 • 42 citations

Gene-modified tumor cells as cellular vaccine

1996 • 36 citations

Methods for the Construction of Retroviral Vectors and the Generation of High-Titer Producers

2003 • 30 citations

Phosphorylation of each of the distal three tyrosines of the CD28 cytoplasmic tail is required for CD28‐induced T cell IL‐2 secretion

1996 • 26 citations

CD28-Mediated Cytotoxicity of YT Natural Killer Cells on B7-Positive Targets Induces Rapid Necrotic Death Independent of Granule Exocytosis

1996 • 15 citations

CD28 costimulation regulates long-term expression of the three genes (α, β, γ) encoding the high-affinity IL2 receptor

1995 • 14 citations

A comparison of three statistical models for IDDM associations with HLA

1996 • 8 citations

Methods for Retrovirus-Mediated Gene Transfer into Primary T-Lymphocytes

2003 • 7 citations