Biology of human papillomaviruses

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Retinoblastoma protein recruits histone deacetylase to repress transcription

1998 • 1,231 citations

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

1998 • 1,206 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

1998 • 1,152 citations

Human Cyclin E, a Nuclear Protein Essential for the G₁-to-S Phase Transition

1995 • 1,132 citations

The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity

1987 • 1,127 citations

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

1994 • 1,046 citations

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

1998 • 919 citations

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 • 872 citations

Telomerase activation by the E6 gene product of human papillomavirus type 16

1996 • 825 citations

Viruses in Human Cancers

1991 • 793 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Persistence of Type-Specific Human Papillomavirus Infection among Cytologically Normal Women

1994 • 695 citations

Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas.

1995 • 683 citations

Heterogeneity of the human papillomavirus group

1989 • 677 citations

Identifying Women With Cervical Neoplasia

1999 • 586 citations

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

1995 • 534 citations

Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6

1998 • 513 citations

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1997 • 506 citations

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes.

1996 • 494 citations

High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21^Cip1

1997 • 464 citations

Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames.

1991 • 462 citations

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

1997 • 462 citations

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21^Cip1-mediated inhibition of cdk2

1997 • 461 citations

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1997 • 435 citations

The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300

1999 • 417 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins

1992 • 389 citations

Human papillomavirus type 16 alters human epithelial cell differentiation in vitro.

1988 • 377 citations

The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.

1992 • 375 citations

Regulation of Histone Acetyltransferases p300 and PCAF by the bHLH Protein Twist and Adenoviral Oncoprotein E1A

1999 • 372 citations

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1995 • 361 citations

The epidemiology of cervical carcinogenesis

1995 • 359 citations

A Viral Mechanism for Inhibition of p300 and PCAF Acetyltransferase Activity

1999 • 343 citations

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

1999 • 340 citations

The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and effects the downregulation of the epidermal growth factor receptor in keratinocytes

1993 • 328 citations

Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses.

1992 • 327 citations

The Human Papillomavirus Type 16 E6 Oncoprotein Can Down-Regulate p53 Activity by Targeting the Transcriptional Coactivator CBP/p300

1999 • 325 citations

The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation.

1990 • 323 citations

Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18

1990 • 319 citations

The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth

1999 • 313 citations

Cyclin/Cdk-Dependent Initiation of DNA Replication in a Human Cell-Free System

1997 • 311 citations

Inhibition of Bak-induced apoptosis by HPV-18 E6

1998 • 282 citations

Interaction of Papillomavirus E6 Oncoproteins with a Putative Calcium-Binding Protein

1995 • 272 citations

The E5 oncoprotein of human papillomavirus type 16 inhibits the acidification of endosomes in human keratinocytes

1995 • 257 citations

Cell Cycle Regulation of the Murine Cyclin E Gene Depends on an E2F Binding Site in the Promoter

1996 • 248 citations

The Role of E6AP in the Regulation of p53 Protein Levels in Human Papillomavirus (HPV)-positive and HPV-negative Cells

1998 • 247 citations

The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein

1993 • 246 citations

A point mutational analysis of human papillomavirus type 16 E7 protein

1989 • 241 citations

The Human Papillomavirus Type 16 E6 Gene Alone Is Sufficient To Induce Carcinomas in Transgenic Animals

1999 • 241 citations

Telomerase activity: A biomarker of cell proliferation, not malignant transformation

1997 • 240 citations

The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties

1990 • 238 citations

Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development.

1995 • 234 citations

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein

1992 • 233 citations

Human papillomavirus type 16 E5 gene stimulates the transforming activity of the epidermal growth factor receptor.

1992 • 230 citations

Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming protein.

1991 • 224 citations

Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway

1998 • 219 citations

The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors.

1996 • 212 citations

Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation

1993 • 212 citations

Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types.

1999 • 209 citations

Human papillomavirus types 16 and 18 in carcinomas of the penis from brazil

1986 • 208 citations

Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family.

1996 • 207 citations

The E5 gene from human papillomavirus type 16 is an oncogene which enhances growth factor-mediated signal transduction to the nucleus.

1992 • 207 citations

Prevalence of human papillomavirus type 16 DNA sequences in cervical intraepithelial neoplasia and invasive carcinoma of the cervix

1985 • 205 citations

Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.

1990 • 204 citations

Multiple Functions of Human Papillomavirus Type 16 E6 Contribute to the Immortalization of Mammary Epithelial Cells

1999 • 198 citations

RETRACTED ARTICLE: E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage

2000 • 196 citations

Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation

1995 • 195 citations

The E6 and E7 genes of HPV-18 are sufficient for inducing two-stage in vitro transformation of human keratinocytes.

1989 • 194 citations

Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes

1992 • 177 citations

The bovine papillomavirus E5 transforming protein can stimulate the transforming activity of EGF and CSF-1 receptors

1989 • 176 citations

Bovine papillomavirus transcriptional regulation: localization of the E2-responsive elements of the long control region

1987 • 160 citations

The Papillomavirus E1 Protein Forms a DNA-Dependent Hexameric Complex with ATPase and DNA Helicase Activities

1998 • 156 citations

The Human Papillomavirus (HPV) 16 E2 Protein Induces Apoptosis in the Absence of Other HPV Proteins and via a p53-dependent Pathway

2000 • 153 citations

Human Papillomavirus E7 Oncoproteins Bind a Single Form of Cyclin E in a Complex with cdk2 and p107

1996 • 147 citations

The Human Papillomavirus Type 16 E5 Gene Cooperates with the E7 Gene to Stimulate Proliferation of Primary Cells and Increases Viral Gene Expression

1994 • 141 citations

Binding of the human papillomavirus E1 origin-recognition protein is regulated through complex formation with the E2 enhancer-binding protein.

1994 • 138 citations

Elevated Wild-Type p53 Protein Levels in Human Epithelial Cell Lines Immortalized by the Human Papillomavirus Type 16 E7 Gene

1994 • 137 citations

Human papillomavirus type 18 E7 protein requires intact Cys-X-X-Cys motifs for zinc binding, dimerization, and transformation but not for Rb binding

1993 • 135 citations

The HPV16 E5 Protein: Expression, Detection, and Stable Complex Formation with Transmembrane Proteins in COS Cells

1995 • 134 citations

The E5 oncoprotein of bovine papillomavirus is oriented asymmetrically in golgi and plasma membranes

1989 • 133 citations

The BPV-1 E5 protein, the 16 kDa membrane pore-forming protein and the PDGF receptor exist in a complex that is dependent on hydrophobic transmembrane interactions.

1992 • 131 citations

Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein.

1993 • 128 citations

Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation

1996 • 126 citations

Rb binds c-Jun and activates transcription

1998 • 122 citations

The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein

1993 • 118 citations

Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells.

1990 • 117 citations

The G₂ Checkpoint Is Maintained by Redundant Pathways

1999 • 116 citations

The E5 Gene of HPV-16 Enhances Keratinocyte Immortalization by Full-Length DNA

1996 • 116 citations

Viruses in human cancers

1999 • 115 citations

The Human Papillomavirus Type 16 E6 and E7 Oncoproteins Dissociate Cellular Telomerase Activity from the Maintenance of Telomere Length

1997 • 115 citations

Studies on vaccination against papillomaviruses: Prophylactic and therapeutic vaccination with recombinant structural proteins

1991 • 113 citations

Association of the human papillomavirus type 16 E7 protein with the S-phase-specific E2F-cyclin A complex.

1993 • 113 citations

The human papillomavirus (HPV)-6 and HPV-16 E5 proteins co-operate with HPV-16 E7 in the transformation of primary rodent cells

1995 • 112 citations

Biochemical and biological differences between E7 oncoproteins of the high- and low-risk human papillomavirus types are determined by amino-terminal sequences

1991 • 109 citations

Disruption of the G ₁ /S Transition in Human Papillomavirus Type 16 E7-Expressing Human Cells Is Associated with Altered Regulation of Cyclin E

1998 • 108 citations

Transmission of Human Papillomaviruses from Mother to Child

1993 • 106 citations

HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligase

2000 • 104 citations

Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells.

1992 • 99 citations

Inducible and constitutive enhancer domains in the noncoding region of human papillomavirus type 18

1988 • 94 citations

Identification of a novel retinoblastoma gene product binding site on human papillomavirus type 16 E7 protein.

1994 • 91 citations

Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors

1999 • 91 citations

The Role of the E1 and E2 Proteins in the Replication of Human Papillomavirus Type 31b

1994 • 89 citations

Single amino acid substitutions in "low-risk" human papillomavirus (HPV) type 6 E7 protein enhance features characteristic of the "high-risk" HPV E7 oncoproteins.

1992 • 89 citations

Chromosomal instability is correlated with telomere erosion and inactivation of G2 checkpoint function in human fibroblasts expressing human papillomavirus type 16 E6 oncoprotein

1998 • 87 citations

HPV-16 E7 and adenovirus E1a complex formation with TATA box binding protein is enhanced by casein kinase II phosphorylation.

1996 • 83 citations

Effect of human papillomavirus type 16 oncogenes on MAP kinase activity

1995 • 79 citations

Transforming activity of E5a protein of human papillomavirus type 6 in NIH 3T3 and C127 cells

1990 • 77 citations

Transcriptional activation of several heterologous promoters by the E6 protein of human papillomavirus type 16

1992 • 76 citations

The human papillomavirus E7 protein as a transforming and transactivating factor

1993 • 75 citations

DNA sequence of the HPV-16 E5 ORF and the structural conservation of its encoded protein

1988 • 75 citations

Human papillomavirus infection and intraepithelial, in situ, and invasive carcinoma of penis

1993 • 68 citations

The viral oncoproteins Ad5 E1A, HPV16 E7 and SV40 TAg bind a common region of the TBP-associated factor-110.

1995 • 68 citations

The E5 Protein of HPV-6, but Not HPV-16, Associates Efficiently with Cellular Growth Factor Receptors

1994 • 65 citations

Human Papillomavirus Oncoproteins Alter Differentiation-Dependent Cell Cycle Exit on Suspension in Semisolid Medium

1998 • 65 citations

Initiation of DNA synthesis by human papillomavirus E7 oncoproteins is resistant to p21-mediated inhibition of cyclin E-cdk2 activity

1997 • 64 citations

Host responses to pathogenic Salmonella infection.

1997 • 63 citations

Analysis of the interaction between human papillomavirus type 16 E7 and the TATA-binding protein, TBP.

1997 • 61 citations

New Insights into the Mechanism of Inhibition of p53 by Simian Virus 40 Large T Antigen

1999 • 57 citations

Inhibition of E6 induced degradation of p53 is not sufficient for stabilization of p53 protein in cervical tumour derived cell lines

1999 • 57 citations

Detection of E5 oncoprotein in human papillomavirus type 16-positive cervical scrapes using antibodies raised to synthetic peptides

1994 • 56 citations

A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27Kip1

1998 • 52 citations

Transactivation of Prothymosin α and c-mycPromoters by Human Papillomavirus Type 16 E6 Protein

1997 • 50 citations

Anchorage-Independent Transcription of the Cyclin A Gene Induced by the E7 Oncoprotein of Human Papillomavirus Type 16

1998 • 49 citations

Analysis of human papillomavirus type 16 open reading frame E7 immortalizing function in rat embryo fibroblast cells

1990 • 47 citations

Perturbation of the p53 response by human papillomavirus type 16 E7

1997 • 44 citations

Association of the Human Papillomavirus Type 16 E7 Protein with the S-Phase-Specific E2F-Cyclin A Complex

1993 • 43 citations

E5 oncoprotein retained in the endoplasmic reticulum/cis Golgi still induces PDGF receptor autophosphorylation but does not transform cells.

1995 • 43 citations

HPV16 E6 Oncoprotein Inhibits Apoptosis Induced during Serum–Calcium Differentiation of Foreskin Human Keratinocytes

1999 • 43 citations

A Mutagenic Analysis of the E5 Protein of Human Papillomavirus Type 16 Reveals That E5 Binding to the Vacuolar H+-ATPase Is Not Sufficient for Biological Activity, Using Mammalian and Yeast Expression Systems

2000 • 41 citations

The E6 Protein of Human Papillomavirus Type 16 Functions as a Transcriptional Repressor in a Mechanism Independent of the Tumor Suppressor Protein, p53

1994 • 39 citations

A Mutational Analysis of the Amino Terminal Domain of the Human Papillomavirus Type 16 E7 Oncoprotein

1994 • 38 citations

Mapping of HPV-11 E1 Binding Site and Determination of Other ImportantcisElements for Replication of the Origin

1996 • 35 citations

The molecular biology of cervical cancer

1995 • 25 citations

Human papillomaviruses and cervical cancer

1998 • 14 citations

Determination of the functional difference between human papillomavirus type 6 and 16 E7 proteins by their 30 N-terminal amino acid residues

1992 • 11 citations

Human papillomavirus and skin cancer

1994 • 8 citations