A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27Kip1

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Principles of CDK regulation

1995 • 3,267 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Human Cyclin E, a Nuclear Protein Essential for the G₁-to-S Phase Transition

1995 • 1,132 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

1998 • 1,058 citations

D-type cyclins

1995 • 978 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1995 • 894 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6

1995 • 657 citations

Regulation of the cyclin E gene by transcription factor E2F1.

1995 • 634 citations

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1995 • 515 citations

Regulation of cell proliferation by the E2F transcription factors

1998 • 486 citations

Different Roles for Cyclins D1 and E in Regulation of the G₁-to-S Transition

1995 • 469 citations

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

1997 • 468 citations

Growth suppression by p16ink4 requires functional retinoblastoma protein.

1995 • 441 citations

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1997 • 435 citations

Identification of a growth suppression domain within the retinoblastoma gene product.

1992 • 413 citations

Cdk inhibitors in development and cancer

1996 • 410 citations

Control of pRB phosphorylation

1998 • 389 citations

Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.

1996 • 387 citations

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase

1998 • 382 citations

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

1997 • 381 citations

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15

1997 • 378 citations

Cyclin D1 Is Dispensable for G₁ Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity

1995 • 370 citations

Myc and the cell cycle

1998 • 360 citations

What is the restriction point?

1995 • 345 citations

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.

1997 • 344 citations

Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27.

1997 • 326 citations

Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.

1996 • 319 citations

Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300.

1995 • 305 citations

Altered Cell Cycle Kinetics, Gene Expression, and G₁ Restriction Point Regulation in Rb-Deficient Fibroblasts

1996 • 301 citations

Deregulated Expression of E2F Family Members Induces S-Phase Entry and Overcomes p16^INK4A-Mediated Growth Suppression

1996 • 297 citations

Differential Interaction of the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 with Cyclin A-Cdk2 and Cyclin D2-Cdk4

1997 • 284 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

1998 • 261 citations

The transcription factor E2F is required for S phase during Drosophila embryogenesis.

1995 • 259 citations

c-Myc or Cyclin D1 Mimics Estrogen Effects on Cyclin E-Cdk2 Activation and Cell Cycle Reentry

1998 • 257 citations

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

1995 • 254 citations

Chemical inhibitors of cyclin-dependent kinases

1996 • 251 citations

RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila.

1996 • 250 citations

DNA tumor virus transforming proteins and the cell cycle

1993 • 242 citations

Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F.

1995 • 229 citations

p27Kip1 overexpression causes apoptotic death of mammalian cells

1997 • 228 citations

Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry

1998 • 227 citations

Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27Kip1 binding to newly formed complexes

1997 • 226 citations

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.

1995 • 210 citations

Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis.

1990 • 209 citations

Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins

1997 • 206 citations

Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells

1996 • 206 citations

Cloning and characterization of murine p16INK4a and p15INK4b genes.

1995 • 197 citations

Requirement for tyrosine phosphorylation of Cdk4 in Gl arrest induced by ultraviolet irradiation

1995 • 187 citations

Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes

1997 • 171 citations

ADENOVIRUS E1A PROTEINS AND TRANSFORMATION (REVIEW)

1994 • 153 citations

Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer, and induction of proliferating cell nuclear antigen

1989 • 150 citations

Adenovirus E1A targets key regulators of cell proliferation.

1992 • 148 citations

Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFβ-treated cells

1996 • 135 citations

Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis.

1996 • 127 citations

E2F-induced S phase requires cyclin E.

1996 • 119 citations

Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.

1996 • 115 citations

Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases.

1996 • 110 citations

p300 and CBP as transcriptional regulators and targets of oncogenic events.

1996 • 110 citations

S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation

1997 • 107 citations

E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP.

1996 • 104 citations

Mutations of the Drosophila dDP,dE2F, and cyclin E Genes Reveal Distinct Roles for the E2F-DP Transcription Factor and Cyclin E during the G₁-S Transition

1998 • 100 citations

Functional interactions within adenovirus E1A protein complexes.

1994 • 100 citations

Effects of Ad5 E1A mutant viruses on the cell cycle in relation to the binding of cellular proteins including the retinoblastoma protein and cyclin A

1992 • 96 citations

Adenovirus E1A proteins interact with the cellular YY1 transcription factor

1995 • 96 citations

Use of deletion and point mutants spanning the coding region of the adenovirus 5 E1A gene to define a domain that is essential for transcriptional activation

1988 • 88 citations

Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein

1998 • 86 citations

Functional interactions between YY1 and adenovirus E1A

1995 • 84 citations

E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest

1996 • 76 citations

Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2.

1996 • 71 citations

Chemical inhibitors of cyclin-dependent kinases

1995 • 69 citations

Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A.

1994 • 68 citations

Differential Regulation of RNA Polymerases I, II, and III by the TBP-Binding Repressor Dr1

1994 • 68 citations

The E1A products of oncogenic adenovirus serotype 12 include amino-terminally modified forms able to bind the retinoblastoma protein but not p300

1993 • 37 citations

S-phase induction by adenovirus E1A requires activation of cdc25a tyrosine phosphatase.

1996 • 34 citations

The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains

1995 • 26 citations

Extreme N terminus of E1A oncoprotein specifically associates with a new set of cellular proteins

1997 • 18 citations

Mutations of the Drosophila dDP, dE2F, and cyclin E Genes Reveal Distinct Roles for the E2F-DP Transcription Factor and Cyclin E during the G1-S Transition

1998 • 6 citations