The Human Papillomavirus (HPV) 16 E2 Protein Induces Apoptosis in the Absence of Other HPV Proteins and via a p53-dependent Pathway

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

1996 • 904 citations

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 • 872 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

Human papillomaviruses in the pathogenesis of anogenital cancer

1991 • 855 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines

1987 • 760 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Crystal structure at 1.7 Å of the bovine papillomavirus-1 E2 DMA-binding domain bound to its DNA target

1992 • 344 citations

Disruption of either the E1 or the E2 regulatory gene of human papillomavirus type 16 increases viral immortalization capacity.

1992 • 315 citations

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.

1994 • 310 citations

p53 and apoptosis

1998 • 282 citations

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription.

1992 • 272 citations

p53 point mutation in HPV negative human cervical carcinoma cell lines.

1991 • 271 citations

Destabilization of the RB Tumor Suppressor Protein and Stabilization of p53 Contribute to HPV Type 16 E7-Induced Apoptosis

1997 • 260 citations

Suppression of cellular proliferation by the papillomavirus E2 protein

1995 • 220 citations

Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis

1997 • 219 citations

Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains.

1988 • 213 citations

The hepatitis B virus X gene induces p53-mediated programmed cell death

1997 • 199 citations

Association of bovine papillomavirus type 2 and bracken fern with bladder cancer in cattle.

1992 • 194 citations

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein

1997 • 183 citations

Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes.

1994 • 178 citations

Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes

1992 • 177 citations

Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene

1993 • 159 citations

Functional p53 protein in human papillomavirus-positive cancer cells.

1995 • 146 citations

Transactivation-Competent Bovine Papillomavirus E2 Protein Is Specifically Required for Efficient Repression of Human Papillomavirus Oncogene Expression and for Acute Growth Inhibition of Cervical Carcinoma Cell Lines

1998 • 112 citations

The E7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosis

1998 • 106 citations

Papillomavirus Reviews: Current Research on Papillomaviruses

1996 • 99 citations

Crystal structure of the E2 DNA-binding domain from human papillomavirus type 16: implications for its DNA binding-site selection mechanism

1998 • 91 citations

Activation of the endogenous p53 growth inhibitory pathway in HeLa cervical carcinoma cells by expression of the bovine papillomavirus E2 gene.

1996 • 90 citations

Experimental reproduction of the papilloma-carcinoma complex of the alimentary canal in cattle

1994 • 85 citations

Abrogation of a mitotic checkpoint by E2 proteins from oncogenic human papillomaviruses correlates with increased turnover of the p53 tumor suppressor protein

1997 • 84 citations

The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops.

1991 • 78 citations

Disruption of the human papillomavirus type 16 E2 gene protects cervical carcinoma cells from E2F-induced apoptosis.

1997 • 58 citations

Enhanced transcriptional activation by E2 proteins from the oncogenic human papillomaviruses

1996 • 52 citations

Mechanism of action of the papillomavirus E2 repressor: repression in the absence of DNA binding

1992 • 49 citations

Integration of high-risk human papillomavirus DNA is linked to the down-regulation of class I human leukocyte antigens by steroid hormones in cervical tumor cells.

1997 • 42 citations

IN-VIVO ANALYSIS OF HPV E7 PROTEIN ASSOCIATION WITH PRB, P107 AND P130

1995 • 31 citations