Anchorage-Independent Transcription of the Cyclin A Gene Induced by the E7 Oncoprotein of Human Papillomavirus Type 16

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

Human Cyclin E, a Nuclear Protein Essential for the G₁-to-S Phase Transition

1995 • 1,132 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

1989 • 913 citations

E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

1996 • 904 citations

Human papillomaviruses in the pathogenesis of anogenital cancer

1991 • 855 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

Regulation of the cyclin E gene by transcription factor E2F1.

1995 • 634 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1997 • 506 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21^Cip1-mediated inhibition of cdk2

1997 • 461 citations

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.

1996 • 453 citations

A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression

1993 • 399 citations

Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

1994 • 393 citations

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins

1992 • 389 citations

Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage

1996 • 371 citations

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.

1995 • 363 citations

Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein.

1996 • 329 citations

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts.

1993 • 325 citations

D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

1994 • 322 citations

Differential modulation of cyclin gene expression by MYC.

1993 • 321 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

Structure and cell cycle-regulated transcription of the human cyclin A gene.

1994 • 272 citations

The Role of Papillomaviruses in Human Anogenital Cancer

1987 • 267 citations

Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines.

1994 • 260 citations

Cyclin A-Associated Kinase Activity Is Rate Limiting for Entrance into S Phase and Is Negatively Regulated in G₁ by p27^Kip1

1995 • 252 citations

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

1994 • 243 citations

A point mutational analysis of human papillomavirus type 16 E7 protein

1989 • 241 citations

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein

1992 • 233 citations

E2F-5, a New E2F Family Member That Interacts with p130 In Vivo

1995 • 232 citations

Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1.

1996 • 227 citations

Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation

1993 • 212 citations

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.

1995 • 210 citations

Functional Analyses of the Transcription Factor Sp4 Reveal Properties Distinct from Sp1 and Sp3

1995 • 208 citations

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.

1996 • 207 citations

Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression

1997 • 203 citations

Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation

1995 • 195 citations

The subcellular localization of E2F-4 is cell-cycle dependent

1997 • 193 citations

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein

1997 • 183 citations

Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes

1992 • 177 citations

Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins

1996 • 176 citations

Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation.

1995 • 168 citations

Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members

1996 • 151 citations

Human Papillomavirus E7 Oncoproteins Bind a Single Form of Cyclin E in a Complex with cdk2 and p107

1996 • 147 citations

Human papillomavirus type 16 open reading frame E7 encodes a transforming gene for rat 3Y1 cells

1988 • 143 citations

HPV16 E7 protein associates with the protein kinase p33CDK2 and cyclin A.

1993 • 141 citations

Anchorage-Dependent Transcription of the Cyclin A Gene

1996 • 136 citations

Human papillomavirus type 18 E7 protein requires intact Cys-X-X-Cys motifs for zinc binding, dimerization, and transformation but not for Rb binding

1993 • 135 citations

Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130.

1995 • 129 citations

Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation

1996 • 126 citations

p27^KIP1 Blocks Cyclin E-Dependent Transactivation of Cyclin A Gene Expression

1997 • 119 citations

The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein

1993 • 118 citations

Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells.

1990 • 117 citations

Association of the human papillomavirus type 16 E7 protein with the S-phase-specific E2F-cyclin A complex.

1993 • 113 citations

Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism

1991 • 108 citations

Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells.

1992 • 99 citations

Cells expressing HPV16 E7 continue cell cycle progression following DNA damage induced p53 activation.

1994 • 84 citations

Papovaviridae: The Papillomaviruses

1988 • 73 citations

Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal

1996 • 73 citations

E2F and the molecular mechanisms of early cell-cycle control

1996 • 71 citations

Initiation of DNA synthesis by human papillomavirus E7 oncoproteins is resistant to p21-mediated inhibition of cyclin E-cdk2 activity

1997 • 64 citations

Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma

1988 • 61 citations

Human papillomavirus type 48

1989 • 59 citations

Accumulation of human papillomavirus type 16 E7 protein bypasses G1 arrest induced by serum deprivation and by the cell cycle inhibitor p21

1997 • 55 citations

Perturbation of the p53 response by human papillomavirus type 16 E7

1997 • 44 citations

Molecular and functional characterisation of E2F-5, a new member of the E2F family.

1995 • 43 citations

Association of the Human Papillomavirus Type 16 E7 Protein with the S-Phase-Specific E2F-Cyclin A Complex

1993 • 43 citations

Down-regulation of cyclin A gene expression upon genotoxic stress correlates with reduced binding of free E2F to the promoter.

1997 • 39 citations

Cell cycle-dependent disruption of E2F-p107 complexes by human papillomavirus type 16 E7

1995 • 27 citations

Analysis of the p53-Mediated G 1 Growth Arrest Pathway in Cells Expressing the Human Papillomavirus Type 16 E7 Oncoprotein

1997 • 17 citations