Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.

1983 • 2,011 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.

1984 • 1,308 citations

Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers.

1983 • 893 citations

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells

1991 • 592 citations

Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA

1987 • 533 citations

The mesothelial keratins: A new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia

1982 • 523 citations

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1989 • 508 citations

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

1990 • 402 citations

Human papillomavirus type 16 alters human epithelial cell differentiation in vitro.

1988 • 377 citations

The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation.

1990 • 323 citations

Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18

1990 • 319 citations

Comparison of the in vitro transforming activities of human papillomavirus types.

1988 • 303 citations

Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma.

1988 • 259 citations

Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma

1989 • 247 citations

A point mutational analysis of human papillomavirus type 16 E7 protein

1989 • 241 citations

Papillomavirus polypeptides E6 and E7 are zinc-binding proteins

1989 • 239 citations

Prevalence of human papillomavirus type 16 DNA sequences in cervical intraepithelial neoplasia and invasive carcinoma of the cervix

1985 • 205 citations

The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein

1987 • 203 citations

The E6-E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells

1987 • 180 citations

Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells

1989 • 171 citations

The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene.

1988 • 130 citations

Dissociation of Rb-binding and anchorage-independent growth from immortalization and tumorigenicity using SV40 mutants producing N-terminally truncated large T antigens

1990 • 95 citations

Identification of a region of simian virus 40 large T antigen required for cell transformation

1990 • 90 citations

Purification and characterization of human papillomavirus type 16 E7 protein with preferential binding capacity to the underphosphorylated form of retinoblastoma gene product

1991 • 89 citations

The viral transcriptional regulatory region upstream of the E6 and E7 genes is a major determinant of the differential immortalization activities of human papillomavirus types 16 and 18

1991 • 78 citations

Mutations of the human papillomavirus type 16 E7 gene that affect transformation, transactivation and phosphorylation by the E7 protein

1990 • 50 citations

Analysis of human papillomavirus type 16 open reading frame E7 immortalizing function in rat embryo fibroblast cells

1990 • 47 citations

Retinoblastoma protein and simian virus 40-dependent immortalization of human fibroblasts

1991 • 43 citations

Human Papillomavirus Types 6 and 16 in Cooperation with Ha-ras Transform Secondary Rat Embryo Fibroblasts

1989 • 29 citations

Two strains of human keratinocytes transfected with HPV16 DNA: comparison with the normal parental cells

1991 • 28 citations