Binding of the human papillomavirus E1 origin-recognition protein is regulated through complex formation with the E2 enhancer-binding protein.

Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames.

1991 • 462 citations

Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations.

1992 • 461 citations

Biosynthesis of Human Papillomavirus from a Continuous Cell Line Upon Epithelial Differentiation

1992 • 448 citations

Targeting the E1 Replication Protein to the Papillomavirus Origin of Replication by Complex Formation with the E2 Transactivator

1990 • 396 citations

Crystal structure at 1.7 Å of the bovine papillomavirus-1 E2 DMA-binding domain bound to its DNA target

1992 • 344 citations

Transcriptional elements as components of eukaryotic origins of DNA replication

1988 • 341 citations

Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA

1987 • 330 citations

Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins.

1992 • 302 citations

Activation of BPV-1 replication in vitro by the transcription factor E2

1991 • 284 citations

Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation

1991 • 272 citations

Identification of the origin of replication of bovine papillomavirus and characterization of the viral origin recognition factor E1.

1991 • 257 citations

Binding of a simian virus 40 T antigen-related protein to DNA

1981 • 233 citations

Multiple EBNA1-binding sites are required to form an EBNA1-dependent enhancer and to activate a minimal replicative origin within oriP of Epstein-Barr virus

1989 • 217 citations

Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2.

1993 • 214 citations

Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication.

1993 • 200 citations

Specific recognition nucleotides and their DNA context determine the affinity of E2 protein for 17 binding sites in the BPV-1 genome.

1989 • 195 citations

Transient replication of human papillomavirus DNAs

1992 • 177 citations

Bovine papilloma virus (BPV)-encoded E2 protein enhances binding of E1 protein to the BPV replication origin.

1993 • 165 citations

Papillomavirus DNA replication

1991 • 127 citations

The bovine papillomavirus origin of replication requires a binding site for the E2 transcriptional activator.

1993 • 127 citations

The 68-kilodalton E1 protein of bovine papillomavirus is a DNA binding phosphoprotein which associates with the E2 transcriptional activator in vitro

1991 • 112 citations

Specific transcription factors stimulate simian virus 40 and polyomavirus origins of DNA replication.

1992 • 99 citations

A bovine papillomavirus E1-related protein binds specifically to bovine papillomavirus DNA

1991 • 98 citations

Formation of the complex of bovine papillomavirus E1 and E2 proteins is modulated by E2 phosphorylation and depends upon sequences within the carboxyl terminus of E1.

1991 • 96 citations

Identification of a 68-kilodalton nuclear ATP-binding phosphoprotein encoded by bovine papillomavirus type 1

1990 • 89 citations

Regulation of DNA replication in vitro by the transcriptional activation domain of GAL4-VP16.

1992 • 89 citations

The Role of the E1 and E2 Proteins in the Replication of Human Papillomavirus Type 31b

1994 • 89 citations

Two E2 binding sites (E2BS) alone or one E2BS plus an A/T-rich region are minimal requirements for the replication of the human papillomavirus type 11 origin

1993 • 88 citations

Genetic assignment of multiple E2 gene products in bovine papillomavirus-transformed cells

1989 • 73 citations

Myc-Mediated Apoptosis Is Blocked by Ectopic Expression of Bcl-2

1993 • 57 citations

Specific Transcription Factors Stimulate Simian Virus 40 and Polyomavirus Origins of DNA Replication

1992 • 45 citations