Lipid Modulators of Epidermal Proliferation and Differentiation

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis

1981 • 1,650 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Perspectives in platelet-activating factor research.

1987 • 1,383 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

LEUKOCYTE-DEPENDENT HISTAMINE RELEASE FROM RABBIT PLATELETS

1972 • 1,214 citations

Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).

1979 • 1,203 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester.

1979 • 1,019 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Platelet-activating factor.

1990 • 904 citations

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

1990 • 889 citations

PLATELET ACTIVATING FACTOR: A BIOLOGICALLY ACTIVE PHOSPHOGLYCERIDE

1986 • 781 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Biosynthesis and Function of Gangliosides

1976 • 748 citations

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.

1986 • 702 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis.

1975 • 583 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

CHRONIC AUTONOMIC FAILURE WITH POSTURAL HYPOTENSION*1

1979 • 507 citations

Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation.

1984 • 501 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

Metabolism and Effects of Epidermal Growth Factor and Related Growth Factors in Mammals*

1990 • 367 citations

Cellular ras activity and phospholipid metabolism

1988 • 331 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

Phospholipid degradation and signal translation for protein phosphorylation

1983 • 323 citations

Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages

1984 • 316 citations

Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.

1986 • 307 citations

Nonimmunological Production pf Leukotrienes Induced by Platelet-Activating Factor

1982 • 305 citations

Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations.

1990 • 303 citations

Alfred P. Sloan Jr. prize. Studies and prospectives of the protein kinase C family for cellular regulation

1989 • 298 citations

Phospholipid-sensitive Ca2+-dependent protein kinase from heart. II. Substrate specificity and inhibition by various agents.

1982 • 290 citations

Altered [125I] Epidermal Growth Factor Binding and Receptor Distribution in Psoriasis

1986 • 289 citations

Commentary on ‘Effects of acetylcholine on the turnover of phosphoryl units in individuals phospholipids of pancreas slices and brain cortex slices’ by L.E. Hokin and M.R. Hokin Biochim. Biophys. Acta 18 (1955) 102–110

1989 • 282 citations

Modulation of protein kinase C and diverse cell functions by sphingosine — a pharmacologically interesting compound linking sphingolipids and signal transduction

1989 • 281 citations

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1989 • 259 citations

Proposed mechanism of cholinergic action in smooth muscle

1980 • 256 citations

Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols.

1986 • 254 citations

Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices

1955 • 253 citations

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds

1989 • 247 citations

Cell regulation by sphingosine and more complex sphingolipids

1991 • 242 citations

Mechanisms of action of calcium‐mobilizing agonists: some variations on a young theme

1988 • 236 citations

Melanoma, Growth Factors, Acanthosis Nigricans, the Sign of Leser-Trélat, and Multiple Acrochordons

1987 • 235 citations

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.

1990 • 230 citations

Sphingosine inhibits calmodulin-dependent enzymes.

1988 • 215 citations

Insulin Rapidly Increases Diacylglycerol by Activating De Novo Phosphatidic Acid Synthesis

1987 • 200 citations

A novel ganglioside, de-N-acetyl-GM3 (II3NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth.

1988 • 183 citations

Syngeneic monoclonal antibody against melanoma antigen with interspecies cross-reactivity recognizes GM3, a prominent ganglioside of B16 melanoma.

1985 • 171 citations

Phosphoinositide metabolism and the control of cell proliferation

1989 • 165 citations

GM3 ganglioside induces hamster fibrobiast growth inhibition in chemically-defined medium: Ganglioside may regulate growth factor receptor function

1982 • 164 citations

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal growth factor receptor.

1988 • 162 citations

Sphingolipid Biochemistry

1983 • 162 citations

Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.

1987 • 156 citations

Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.

1988 • 151 citations

Platelet-Activating Factor and Related Lipid Mediators

1987 • 147 citations

Early signals for keratinocyte differentiation: role of Ca²⁺-mediated inositol lipid metabolism in normal and neoplastic epidermal cells

1988 • 140 citations

The stereospecific activation of protein kinase C

1984 • 135 citations

Stimulation of phosphatidic acid of calcium influx and cyclic GMP synthesis in neuroblastoma cells.

1981 • 135 citations

Exogenous glycosphingolipids suppress growth rate of transformed and untransformed 3T3 mouse cells

1975 • 135 citations

Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells.

1990 • 134 citations

Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni

1986 • 132 citations

Identification, isolation and characterization of epidermal lipids containing linoleic acid

1985 • 131 citations

Inflammatory characteristics of platelet activating factor (PAF-acether) in human skin

1984 • 129 citations

Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes.

1986 • 125 citations

Distribution and number of epidermal growth factor receptors in skin is related to epithelial cell growth

1983 • 124 citations

Metabolism of essential fatty acids by human epidermal enzyme preparations: evidence of chain elongation.

1990 • 121 citations

Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes.

1988 • 116 citations

A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells.

1990 • 115 citations

Differences in Human Skin Between the Epidermal Growth Factor Receptor Distribution Detected by EGF Binding and Monoclonal Antibody Recognition

1985 • 113 citations

Structural identification of platelet activating factor in psoriatic scale

1985 • 110 citations

Ganglioside GD3: structure, cellular distribution, and possible function

1985 • 105 citations

Accumulation of inflammatory cells in response to intracutaneous platelet activating factor (Paf-acether) in mang

1985 • 105 citations

Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells.

1990 • 103 citations

Sphingosine Inhibits Phorbol Ester-Induced Inflammation, Ornithine Decarboxylase Activity, and Activation of Protein Kinase C in Mouse Skin

1988 • 99 citations

Structural requirements for diacylglycerols to mimic tumor-promoting phobol diester action on the epidermal growth factor receptor.

1985 • 98 citations

Phosphatidate as a Molecular Link Between Depolarization and Neurotransmitter Release in the Brain

1981 • 95 citations

Activation and regulation of protein Kinase C enzymes

1991 • 95 citations

Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor.

1988 • 93 citations

Structural and chemical specificity of diradylglycerols for protein kinase C activation

1984 • 92 citations

A ceramide analog inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis

1990 • 92 citations

Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid

1984 • 90 citations

Platelet-Activating Factor Antagonists

1987 • 88 citations

Possible involvement of a GTP-binding protein, the substrate of islet-activating protein, in receptor-mediated signaling responsible for cell proliferation.

1987 • 85 citations

Cell Membranes Methods and Reviews

1983 • 84 citations

Characterization of a proline-rich cell wall protein gene family of soybean. A comparative analysis.

1990 • 81 citations

Differential expression of ganglioside GD3 by human leukocytes and leukemia cells.

1984 • 74 citations

Demonstration of anaphylatoxins C3a, C4a and C5a in the scales of psoriasis and inflammatory pustular dermatoses

1986 • 74 citations

Enzymatic synthesis of N,N-dimethyl-sphingosine: Demonstration of the sphingosine: N-methyltransferase in mouse brain

1989 • 73 citations

The level of phospholipase A2 activity is raised in the uninvolved epidermis of psoriasis

1983 • 72 citations

Free Sphingosine in Human Epidermis

1990 • 68 citations

Leukotrienes C4 and D4 psoriatic skin lesions

1985 • 66 citations

Epidermal Growth Factor/Transforming Growth Factor Alpha Receptors and Psoriasis

1990 • 66 citations

Increased monocyte chemotaxis towards leukotriene B4 and platelet activating factor in patients with inflammatory dermatoses.

1983 • 61 citations

Modified ganglioside as a possible modulator of transmembrane signaling mechanism through growth factor receptors: A preliminary note

1987 • 59 citations

Expression of the gangliosides GM3, GD3 and GD2 in tissue sections of normal skin, naevi, primary and metastatic melanoma

1988 • 58 citations

Sphingosine inhibits thyrotropin-releasing hormone binding to pituitary cells by a mechanism independent of protein kinase C.

1988 • 56 citations

Protein kinase C and platelet inhibition by D-erythro-sphingosine: Comparison with N,N-dimethylsphingosine and commercial preparation

1990 • 56 citations

Ceramidase activity in porcine epidermis

1990 • 55 citations

Increased Phospholipase C-Catalyzed Hydrolysis of Phosphatidylinositol-4,5-Bisphosphate and 1,2-sn-Diacylglycerol Content in Psoriatic Involved Compared to Uninvolved and Normal Epidermis

1990 • 54 citations

Phosphatidylinositol-4,5-bisphosphate may antecede diacylglycerol as activator of protein kinase C

1988 • 54 citations

Occurrence of an endogenous inhibitor of platelet-activating factor in rat liver.

1987 • 54 citations

Existence of endogenous inhibitors of platelet-activating factor (PAF) with PAF in rat uterus.

1987 • 53 citations

Free sphingosines in porcine epidermis

1989 • 53 citations

Evidence that phosphatidic acid stimulates the uptake of calcium by liver cells but not calcium release from mitochondria

1981 • 52 citations

Effects of gangliosides GM3 and De-N-acetyl GM3 on epidermal growth factor receptor kinase activity and cell growth

1991 • 51 citations

Dietary Influences of Evening Primrose and Fish Oil on the Skin of Essential Fatty Acid-Deficient Guinea Pigs

1987 • 48 citations

Phospholipid metabolism in calcium-regulated differentiation in cultured murine keratinocytes

1984 • 47 citations

Lipid Modulators of Cell Function

2009 • 45 citations

Production of Paf-Acether by Human Epidermal Cells

1990 • 40 citations

Cell cycle phases of a novel human neural cell line and the effect of exogenous gangliosides

1982 • 39 citations

Eicosanoids and the Skin

1990 • 39 citations

Cardiac and coronary consequences of intracoronary platelet activating factor infusion in the domestic pig

1987 • 36 citations

Density-dependent expression of ganglioside GM3 by human skin fibroblasts in an all-or-none fashion, as a possible modulator of cell growth in vitro

1990 • 31 citations

Confirmation of raised phospholipase A2 activity in the uninvolved skin of psoriasis

1984 • 29 citations

Insulin and phorbol ester stimulate conductive Na+ transport through a common pathway.

1988 • 28 citations

Phosphatidic acid mimicks the muscarinic action of acetylcholine in cultured bovine chromaffin cells

1983 • 28 citations

Lipid activators of protein kinase C

1990 • 27 citations

Weak inhibition of protein kinase C coupled with various non-specific effects make sphingosine an unsuitable tool in platelet signal transduction studies

1989 • 27 citations

Acylceramides and lanosterol-lipid markers of terminal differentiation in cultured human keratinocytes: Modulating effect of retinoic acid

1991 • 27 citations

Differentiation of human keratinocytes: Changes in lipid synthesis, plasma membrane lipid composition, and ¹²⁵I‐EGF binding upon administration of 25‐hydroxycholesterol and mevinolin

1987 • 24 citations

Activation of keratinization of keratinocytes from fetal rat skin with N-(O-linoleoyl) ω-hydroxy fatty acyl sphingosyl glucose (lipokeratinogenoside) as a marker of epidermis

1990 • 22 citations

Differential activation of human skin cells by platelet activating factor: Stimulation of phosphoinositide turnover and arachidonic acid mobilization in keratinocytes but not in fibroblasts

1989 • 22 citations

Interaction of palmitoyl carnitine with calcium antagonists in myocytes

1989 • 21 citations

Thyrotropin-releasing hormone and phorbol esters stimulate sphingomyelin synthesis in GH3 pituitary cells

1989 • 20 citations

Absence of a Stratum Corneum Antigen in Disorders of Epidermal Cell Proliferation: Detection with an Anti-Ganglioside GM3 Antibody

1989 • 15 citations

Enhancement of Keratin Synthesis Induced by Lipokeratinogenoside, N-(O-Linoleoyl)-ω-Hydroxy Fatty Acyl Sphingosyl Glucose, in Association with Alteration of the Intracellular Ca2+-Content and Protein Kinase in Cultured Keratinocytes (FRSK)1

1991 • 12 citations

Changes in glycosphingolipids accompanying the differentiation of human squamous SQCC/Y1 cells.

1988 • 12 citations

Inhibition of epidermal growth factor binding in rat pancreatic acini by palmitoyl carnitine: evidence for Ca2+ and protein kinase C independent regulation.

1987 • 10 citations

The Role of Epidermal Growth Factor in Skin Diseases

1988 • 10 citations

Ganglioside and morphological changes in mouse embryo cells with time

1978 • 8 citations

Plate Tectonics Is the Key to the Distant Past

1986 • 3 citations