Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Construction and applications of a highly transmissible murine retrovirus shuttle vector

1984 • 1,020 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.

1986 • 702 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells.

1984 • 331 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.

1986 • 307 citations

Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity.

1985 • 284 citations

Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.

1985 • 244 citations

Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.

1984 • 219 citations

Chemistry and Metabolism of Sphingolipids. 3-Oxo Derivatives of N-Acetylsphingosine and N-Acetyldihydrosphingosine

1966 • 185 citations

Structure and localization of genes encoding aberrant and normal epidermal growth factor receptor RNAs from A431 human carcinoma cells.

1985 • 171 citations

beta-Adrenergic regulation of insulin and epidermal growth factor receptors in rat adipocytes.

1983 • 156 citations

Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells

1983 • 151 citations

Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s).

1986 • 145 citations

Reversal of X-inactivation in female mouse somatic cells hybridized with murine teratocarcinoma stem cells in vitro

1983 • 127 citations

EGF receptor affinity is regulated by intracellular calcium and protein kinase C

1985 • 114 citations

Further purification of epidermal growth factor by high-performance liquid chromatography

1982 • 103 citations

Regulation of transferrin receptor expression at the cell surface by insulin-like growth factors, epidermal growth factor and platelet-derived growth factor.

1986 • 101 citations

Epidermal growth factor (EGF) promotes phosphorylation at threonine-654 of the EGF receptor: possible role of protein kinase C in homologous regulation of the EGF receptor.

1986 • 89 citations

Stimulation of epidermal growth factor receptor threonine 654 phosphorylation by platelet-derived growth factor in protein kinase C-deficient human fibroblasts.

1987 • 84 citations

Phosphorylation of the EGF receptor from A431 epidermoid carcinoma cells by three distinct types of protein kinase C

1987 • 75 citations

Identification of serine 24 as the unique site on the transferrin receptor phosphorylated by protein kinase C.

1986 • 75 citations

Regulation of transferrin receptor cycling by protein kinase C is independent of receptor phosphorylation at serine 24 in Swiss 3T3 fibroblasts.

1987 • 66 citations

Nonselective inhibition of neutrophil functions by sphinganine.

1987 • 63 citations

Suppression of protein tyrosine kinase activity of the epidermal growth factor receptor by epidermal growth factor.

1986 • 20 citations

Synthesis of epidermal growth factor (EGF) receptor in vitro using SP6 RNA polymerase-transcribed template mRNA

1986 • 17 citations