Platelet-activating factor.

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

PLATELET ACTIVATING FACTOR: A BIOLOGICALLY ACTIVE PHOSPHOGLYCERIDE

1986 • 781 citations

Structure and Properties of a Human Non-pancreatic Phospholipase A2

1989 • 668 citations

A calcium-dependent mechanism for associating a soluble arachidonoyl-hydrolyzing phospholipase A2 with membrane in the macrophage cell line RAW 264.7.

1990 • 447 citations

Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin.

1984 • 442 citations

A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid).

1981 • 440 citations

Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate.

1985 • 430 citations

Human plasma platelet-activating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor.

1987 • 404 citations

Endothelial cell-associated platelet-activating factor: a novel mechanism for signaling intercellular adhesion.

1990 • 391 citations

Human plasma platelet-activating factor acetylhydrolase. Purification and properties.

1987 • 335 citations

Enzymatic synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and platelet-aggregating lipid.

1980 • 321 citations

Nonimmunological Production pf Leukotrienes Induced by Platelet-Activating Factor

1982 • 305 citations

1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes.

1984 • 296 citations

Characterization of serum platelet-activating factor (PAF) acetylhydrolase. Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children.

1988 • 285 citations

Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils.

1986 • 283 citations

An Oxidized Derivative of Phosphatidylcholine is a Substrate for the Platelet-Activating Factor Acetylhydrolase from Human Plasma

1989 • 234 citations

Hydrolysis of phosphatidylcholine during LDL oxidation is mediated by platelet-activating factor acetylhydrolase.

1989 • 220 citations

Human macrophages secret platelet-activating factor acetylhydrolase.

1990 • 216 citations

Distinct platelet-activating factor binding sites in synaptic endings and in intracellular membranes of rat cerebral cortex.

1990 • 213 citations

Production and effects of platelet-activating factor in the rat brain

1988 • 205 citations

1-ether-linked phosphoglycerides. Major endogenous sources of arachidonate in the human neutrophil.

1988 • 180 citations

The intracellular retention of newly synthesized platelet-activating factor.

1986 • 175 citations

Platelet-activating Factor Acetylhydrolase Increases during Macrophage Differentiation

1989 • 159 citations

Production of platelet-activating factor by stimulated human polymorphonuclear leukocytes. Correlation of synthesis with release, functional events, and leukotriene B4 metabolism.

1987 • 145 citations

The Regulation of Platelet-activating Factor Production in Endothelial Cells

1989 • 141 citations

Protein kinase C activity appears to be required for the synthesis of platelet-activating factor and leukotriene B4 by human neutrophils.

1987 • 140 citations

Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni

1986 • 132 citations

Platelet-activating factor and related lipid mediators

1988 • 130 citations

Purification and characterization of a membrane-associated phospholipase A2 from rat spleen. Its comparison with a cytosolic phospholipase A2 S-1.

1988 • 128 citations

Platelet-activating factor and leukotriene biosynthesis is inhibited in polymorphonuclear leukocytes depleted of arachidonic acid.

1986 • 126 citations

Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes.

1986 • 125 citations

Platelet-activating factor may act as a second messenger in the release of icosanoids and superoxide anions from leukocytes and endothelial cells.

1990 • 125 citations

The priming of neutrophils by lipopolysaccharide for production of intracellular platelet-activating factor. Potential role in mediation of enhanced superoxide secretion.

1988 • 123 citations

Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes.

1988 • 116 citations

Solubilization, purification, and characterization of a membrane-bound phospholipase A2 from the P388D1 macrophage-like cell line.

1988 • 114 citations

The final step in the de novo biosynthesis of platelet-activating factor. Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner medulla of rats.

1987 • 104 citations

Regulation of platelet activating factor synthesis: Modulation of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:Acetyl-CoA acetyltransferase by phosphorylation and dephosphorylation in rat spleen microsomes

1984 • 104 citations

Lipoproteins alter the catalytic behavior of the platelet-activating factor acetylhydrolase in human plasma.

1989 • 104 citations

An arachidonoyl (polyenoic)-specific phospholipase A2 activity regulates the synthesis of platelet-activating factor in granulocytic HL-60 cells.

1990 • 104 citations

Stimulation of Platelet-activating Factor Synthesis by a Nonmetabolizable Bioactive Analog of Platelet-activating Factor and Influence of Arachidonic Acid Metabolites

1989 • 98 citations

Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): Role of extracellular albumin

1985 • 97 citations

Platelet-activating factor acetylhydrolase activity in maternal, fetal, and newborn rabbit plasma during pregnancy and lactation.

1988 • 95 citations

Platelet-Activating Factor Antagonists

1987 • 88 citations

Regulation of acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase (lyso-PAF-acetyltransferase) in exocrine glands. Evidence for an activation via phosphorylation by calcium/calmodulin-dependent protein kinase.

1987 • 74 citations

Increased activity of the platelet-activating factor acetylhydrolase in plasma low density lipoprotein from patients with essential hypertension

1989 • 68 citations

Modulation of acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PAF) acetyltransferase in human polymorphonuclears. The role of cyclic AMP-dependent and phospholipid sensitive, calcium-dependent protein kinases.

1988 • 67 citations

Substrate specificity and partial characterization of the PAF-acylhydrolase in human serum that rapidly inactivates platelet-activating factor.

1986 • 67 citations

Stimulated neutrophils produce an ethanolamine plasmalogen analog of platelet-activating factor.

1987 • 64 citations

Role of Na+/H+ exchange in thrombin-induced platelet-activating factor production by human endothelial cells.

1988 • 60 citations

Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production.

1988 • 58 citations

Novel molecular analogues of phosphatidylcholines in a lipid extract from bovine brain: 1-long-chain acyl-2-short-chain acyl-sn-glycero-3-phosphocholines.

1989 • 57 citations

Involvement of Protein Kinase C in Platelet-activating Factor-stimulated Diacylglycerol Accumulation in Murine Peritoneal Macrophages

1989 • 57 citations

Occurrence of an endogenous inhibitor of platelet-activating factor in rat liver.

1987 • 54 citations

Existence of endogenous inhibitors of platelet-activating factor (PAF) with PAF in rat uterus.

1987 • 53 citations

Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human promyelocytic leukemic HL60 cells. Stimulated expression of phospholipase A2 and acetyltransferase requires differentiation.

1986 • 52 citations

Identification of Receptors for Platelet-Activating Factor in Rat Kupffer Cells

1989 • 52 citations

Synthesis of platelet-activating factor by endothelial cells. The role of G proteins.

1990 • 49 citations

Platelet-activating factor (PAF) stimulates the PAF-synthesizing enzyme acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase and PAF synthesis in neutrophils.

1987 • 49 citations

Bidirectional Effects of Protein Kinase C Activators

1989 • 48 citations

Plasma from atherosclerotic patients exerts an increased degradation of platelet-activating factor

1987 • 48 citations

Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086 Correlation between receptor binding and function

1989 • 45 citations

Release of platelet-activating factor and the metabolism of leukotriene B4 by the human neutrophil when studied in a cell superfusion model.

1989 • 44 citations

Thrombin-Treated Endothelium Primes Neutrophil Functions: Inhibition by Platelet-Activating Factor Receptor Antagonists

1989 • 39 citations

Purification and Characterization of Membrane-Bound Phospholipase A2 from Rat Platelets1

1988 • 39 citations

Development of specific functionally active receptors for platelet-activating factor in HL-60 cells following granulocytic differentiation.

1990 • 38 citations

Phorbol 12-myristate 13-acetate inhibits binding of leukotriene B4 and platelet-activating factor and the responses they induce in neutrophils: site of action.

1989 • 37 citations

Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human fetal membranes and decidua vera

1986 • 37 citations

Cardiac and coronary consequences of intracoronary platelet activating factor infusion in the domestic pig

1987 • 36 citations

Conversion of alkylacetylglycerol to platelet-activating factor in HL-60 cells and subcellular localization of the mediator

1990 • 35 citations

The degradation of platelet-activating factor by high-density lipoprotein in rat plasma. Effect of ethynyloestradiol administration

1987 • 35 citations

Selective hydrolysis of ether-containing glycerophospholipids by phospholipase A2 in rabbit lung

1988 • 34 citations

Intracellular localization of platelet-activating factor synthesis in human neutrophils

1988 • 34 citations

Polymorphonuclear Leukocyte-Platelet Interactions: Acetyiglyceryl Ether Phosphocholine-Induced Platelet Activation under Stimulation with Chemotactic Peptide1

1986 • 34 citations

Biosynthesis of paf-acether XIV. Paf-acether output in murine peritoneal macrophages is regulated by the level of acetylhydrolase

1989 • 31 citations

Evidence for protein-catalyzed transfer of platelet activating factor by macrophage cytosol

1988 • 30 citations

Regulation of Platelet-activating Factor Receptors in Rat Kupffer Cells

1989 • 26 citations

Subcellular localization of phospholipids and enzymes involved in PAF‐acether metabolism

1989 • 24 citations

1-0-Hexadec-1′-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity

1988 • 17 citations