Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor.

Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis

1981 • 1,650 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.

1983 • 792 citations

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.

1986 • 702 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Novel Interleukin-2 Receptor Subunit Detected by Cross-Linking Under High-Affinity Conditions

1986 • 585 citations

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

1987 • 565 citations

A nonlinear regression program for small computers

1981 • 563 citations

Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors

1979 • 517 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation.

1984 • 501 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.

1986 • 477 citations

Role of membrane gangliosides in the binding and action of bacterial toxins

1982 • 396 citations

Allosteric regulation of the epidermal growth factor receptor kinase.

1986 • 381 citations

Membrane lipid phase as catalyst for peptide-receptor interactions.

1986 • 375 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.

1986 • 307 citations

Specific gangliosides function as host cell receptors for Sendai virus.

1981 • 262 citations

Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors.

1987 • 252 citations

Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.

1985 • 244 citations

GQlb, a Bioactive Ganglioside that Exhibits Novel Nerve Growth Factor (NGF)Like Activities in the Two Neuroblastoma Cell Lines

1983 • 232 citations

sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis.

1985 • 179 citations

Epidermal growth factor: Biological activity requires persistent occupation of high-affinity cell surface receptors

1978 • 162 citations

beta-Adrenergic regulation of insulin and epidermal growth factor receptors in rat adipocytes.

1983 • 156 citations

Amiloride directly inhibits growth factor receptor tyrosine kinase activity.

1985 • 155 citations

Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells

1983 • 151 citations

Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s).

1986 • 145 citations

Gangliosides as bimodal regulators of cell growth.

1987 • 128 citations

The insulin receptor. Structural basis for high affinity ligand binding.

1987 • 117 citations

Further purification of epidermal growth factor by high-performance liquid chromatography

1982 • 103 citations

Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.

1985 • 101 citations

Isolation of functional alpha beta heterodimers from the purified human placental alpha 2 beta 2 heterotetrameric insulin receptor complex. A structural basis for insulin binding heterogeneity.

1987 • 99 citations

Glycosphingolipids as differentiation-dependent, tumor-associated markers and as regulators of cell proliferation

1984 • 98 citations

High affinity epidermal growth factor receptors on the surface of A431 cells have restricted lateral diffusion.

1984 • 97 citations

Stimulation of epidermal growth factor receptor threonine 654 phosphorylation by platelet-derived growth factor in protein kinase C-deficient human fibroblasts.

1987 • 84 citations

Properties of a monoclonal antibody to epidermal growth factor receptor with implications for the mechanism of action of EGF.

1984 • 77 citations

Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters.

1986 • 76 citations

Gangliosides stimulate astroglial cell proliferation in the absence of serum

1986 • 48 citations

Regulation of kinase and intermolecular bonding in intact and truncated epidermal growth factor receptor.

1986 • 43 citations

Solubilization of EGF receptor with Triton X-100 alters stimulation of tyrosine residue phosphorylation by EGF and dimethyl sulfoxide.

1983 • 42 citations