Increased Phospholipase C-Catalyzed Hydrolysis of Phosphatidylinositol-4,5-Bisphosphate and 1,2-sn-Diacylglycerol Content in Psoriatic Involved Compared to Uninvolved and Normal Epidermis

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

[105] Determination of DNA concentration with diphenylamine

1968 • 1,300 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.

1983 • 601 citations

The second messenger linking receptor activation to internal Ca release in liver

1984 • 557 citations

The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

1982 • 541 citations

Inositol lipids and cell proliferation

1987 • 315 citations

A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.

1986 • 267 citations

Monoclonal antibodies to three phospholipase C isozymes from bovine brain.

1988 • 256 citations

Purification and characterization of two immunologically distinct phosphoinositide-specific phospholipases C from bovine brain.

1987 • 243 citations

Bovine brain cytosol contains three immunologically distinct forms of inositolphospholipid-specific phospholipase C.

1987 • 233 citations

Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes.

1986 • 183 citations

Modulation of phosphatidylinositol-specific phospholipase C activity by phospholipid interactions, diglycerides, and calcium ions.

1982 • 158 citations

Individual molecular species of phospholipids

1966 • 156 citations

Early prostaglandin E synthesis is an obligatory event in the induction of cell proliferation in mouse epidermis in vivo by the phorbol ester TPA

1980 • 147 citations

sn-l, 2-Diacylglycerols mimic the effects of 12-0-tetradecanoylphorbol-13-acetate in vivo by inducing biochemical changes associated with tumor promotion in mouse epidermis

1986 • 142 citations

Regulation of interleukin 1 and its receptor in human keratinocytes.

1989 • 125 citations

Decreased Protein Kinase C Activity in Psoriatic Versus Normal Epidermis

1987 • 123 citations

Vasopressin induces V1 receptors to activate phosphatidylinositol- and phosphatidylcholine-specific phospholipase C and stimulates the release of arachidonic acid by at least two pathways in the smooth muscle cell line, A-10.

1988 • 117 citations

Further studies on the specificity of diacylglycerol for protein kinase C activation

1987 • 106 citations

Sphingosine Inhibits Phorbol Ester-Induced Inflammation, Ornithine Decarboxylase Activity, and Activation of Protein Kinase C in Mouse Skin

1988 • 99 citations

Modulation of tissue and epidermal transglutaminases in mouse epidermal cells after treatment with 12-O-tetradecanoylphorbol-13-acetate and/or retinoic acid in vivo and in culture.

1988 • 88 citations

Receptor-mediated phagocytosis in human neutrophils is associated with increased formation of inositol phosphates and diacylglycerol. Elevation in cytosolic free calcium and formation of inositol phosphates can be dissociated from accumulation of diacylglycerol.

1989 • 84 citations

Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils.

1988 • 79 citations

Vasopressin, phorbol diesters and serum elicit choline glycerophospholipid hydrolysis and diacylglycerol formation in nontransformed cells: transformed derivatives do not respond

1988 • 69 citations

Similar effects of phospholipase C and phorbol ester tumor promoters on primary mouse epidermal cells.

1985 • 63 citations

Pertussis toxin triggers rapid second messenger production in human T lymphocytes.

1987 • 59 citations

Partial Characterization of Phospholipase C Activity in Normal, Psoriatic Uninvolved, and Lesional Epidermis

1987 • 53 citations

Early inflammatory changes in the skin of SENCAR and C57BL/6 mice following exposme to 12-O-tetradecanoylphorbol-13-acetat

1987 • 52 citations

Anticarcinogenic and cocarcinogenic effects of benzo[e]pyrene and dibenz[a,c]anthracene on skin tumor initiation by polycyclic hydrocarbons

1982 • 51 citations

Topical cyclosporine A inhibits the phorbol ester induced hyperplastic inflammatory response but not protein kinase C activation in mouse epidermis

1989 • 45 citations

Biochemical Demonstration and Immunohistochemical Localization of Calpain in Human Skin

1986 • 43 citations

Diacylglycerol-Induced Shape Changes, Movements And Altered F-Actin Distribution In Human Neutrophils

1988 • 41 citations

Agonist-induced Hydrolysis of Phosphoinositides and Formation of 1,2-Diacylglycerol in Adult Human Keratinocytes

1989 • 36 citations

Purification and Characterization of Calcium/Phospholipid-Dependent Kinase From Adult Human Epidermis

1987 • 34 citations

Effect of phorbol esters on guinea pig skin in vivo

1982 • 33 citations

Topical Cyclosporine A Inhibits the Phorbol Ester Induced Hyperplastic Inflammatory Response but not Protein Kinase C Activation in Mouse Epidermis.

1989 • 32 citations

Leukocyte chemoattraction by 1,2-diacylglycerol.

1988 • 30 citations

Increased membrane-associated transglutaminase activity in psoriasis

1989 • 26 citations

Granulocyte/macrophage colony‐stimulating factor primes human neutrophils for increased diacylglycerol generation in response to chemoattractant

1989 • 24 citations

Phosphatidylinositol-specific phospholipase C of murine lymphocytes

1986 • 19 citations

Phospholipase C mimics the differential effects of phorbol-12-myristate-13-acetate on the colony formation and cornification of cultured normal and transformed human keratinocytes

1987 • 18 citations

Membrane-bound phospholipase C activity in normal and psoriatic epidermis.

1990 • 17 citations

Two species of phospholipase C isolated from lymphocytes produce specific ratios of inositol phosphate products

1986 • 16 citations

Cyclosporine inhibits ornithine decarboxylase gene expression and acute inflammation in response to phorbol ester treatment of hairless mouse skin.

1988 • 13 citations

Isoelectric focusing of human platelet phospholipase C: Evidence for multimolecular forms

1987 • 6 citations

[6] Synthesis and use of diacylglycerols as activators of protein kinase C in neuroendocrine tissue

1986 • 6 citations

Deleted Work

1955 • 0 citations