Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

Carbohydrate-Specific Receptors of the Liver

1982 • 1,895 citations

Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis

1981 • 1,650 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion

1970 • 1,208 citations

Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens

1985 • 1,184 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Leukocyte adhesion to endothelium in inflammation

1990 • 882 citations

PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes

1989 • 878 citations

Biosynthesis and Function of Gangliosides

1976 • 748 citations

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.

1986 • 702 citations

ANIMAL GLYCOSPHINGOLIPIDS AS MEMBRANE ATTACHMENT SITES FOR BACTERIA

1989 • 686 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation.

1984 • 501 citations

An update of the enzymology and regulation of sphingomyelin metabolism

1990 • 460 citations

Specific interaction between Lex and Lex Determinants

1989 • 450 citations

Mouse Lymph Node Homing Receptor cDNA Clone Encodes a Glycoprotein Revealing Tandem Interaction Domains

1989 • 428 citations

Intracellular Calcium Release Mediated by Sphingosine Derivatives Generated in Cells

1990 • 391 citations

A multivalent lacto-N-fucopentaose III-lysyllysine conjugate decompacts preimplantation mouse embryos, while the free oligosaccharide is ineffective.

1984 • 291 citations

Modulation of protein kinase C and diverse cell functions by sphingosine — a pharmacologically interesting compound linking sphingolipids and signal transduction

1989 • 281 citations

Glycosphingolipids with Lewis Blood Group Activity: Uptake by Human Erythrocytes

1969 • 262 citations

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1989 • 259 citations

From Epinephrine to Cyclic AMP

1988 • 255 citations

Regulation of protein kinase C activity by gangliosides.

1987 • 248 citations

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds

1989 • 247 citations

Endogenous lectins from cultured cells: nuclear localization of carbohydrate-binding protein 35 in proliferating 3T3 fibroblasts.

1987 • 242 citations

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.

1990 • 230 citations

Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies.

1986 • 217 citations

Specific Interaction between Gangliotriaosylceramide (Gg3) and Sialosyllactosylceramide (GM3) as a Basis for Specific Cellular Recognition between Lymphoma and Melanoma Cells

1989 • 208 citations

Structure and Function of Gangliosides

1980 • 199 citations

Ganglioside GM3: an acidic membrane component that increases during macrophage-like cell differentiation can induce monocytic differentiation of human myeloid and monocytoid leukemic cell lines HL-60 and U937.

1986 • 199 citations

Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins.

1987 • 194 citations

Oligosaccharides containing fucose linked α(1–3) and α(1–4) to N-acetylglucosamine cause decompaction of mouse morulae

1984 • 193 citations

Glycoconjugate expression during embryogenesis and its biological significance

1990 • 186 citations

A novel ganglioside, de-N-acetyl-GM3 (II3NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth.

1988 • 183 citations

Calcium/Ganglioside‐Dependent Protein Kinase Activity in Rat Brain Membrane

1985 • 170 citations

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal growth factor receptor.

1988 • 162 citations

Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.

1988 • 151 citations

Gangliosides shed by tumor cells enhance tumor formation in mice.

1987 • 144 citations

A review of the immunogenic and immuno-modulatory properties of glycosphingolipids

1984 • 140 citations

Biochemical investigations of retinotectal adhesive specificity

1977 • 138 citations

Gangliosides as bimodal regulators of cell growth.

1987 • 128 citations

Identification of the metastasis-associated, galactoside-binding lectin as a chimeric gene product with homology to an IgE-binding protein.

1989 • 126 citations

A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells.

1990 • 115 citations

Gangliosides induce selective modulation of CD4 from helper T lymphocytes.

1987 • 114 citations

Inhibition of human melanoma cell growth in vitro by monoclonal anti-GD3-ganglioside antibody.

1984 • 114 citations

Neolacto-series gangliosides induce granulocytic differentiation of human promyelocytic leukemia cell line HL-60.

1988 • 108 citations

Morphological alterations and ganglioside sialyltransferase activity induced by small fatty acids in HeLa cells.

1975 • 107 citations

Identification of carbohydrate binding protein 35 in heterogeneous nuclear ribonucleoprotein complex

1988 • 106 citations

Bioactive Gangliosides. IV. Ganglioside GQ1b/Ca2+ Dependent Protein Kinase Activity Exists in the Plasma Membrane Fraction of Neuroblastoma Cell Line, GOTO1

1985 • 105 citations

Effects of D‐threo‐PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells

1989 • 99 citations

Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.

1988 • 97 citations

Ganglioside-specific Binding Protein on Rat Brain Membranes

1989 • 94 citations

An IgG3 monoclonal antibody established after immunization with GM3 lactone: immunochemical specificity and inhibition of melanoma cell growth in vitro and in vivo.

1988 • 93 citations

Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor.

1988 • 93 citations

Ganglioside-modulated protein phosphorylation. Partial purification and characterization of a ganglioside-stimulated protein kinase in brain.

1987 • 93 citations

A ceramide analog inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis

1990 • 92 citations

Sialidase Activity in Transformed Cells

1973 • 90 citations

A Novel, Carbohydrate Signal-Mediated Cell Surface Protein Phosphorylation: Ganglioside GQ1b Stimulates Ecto-Protein Kinase Activity on the Cell Surface of a Human Neuroblastoma Cell Line, GOTO2

1988 • 88 citations

Gangliosides and Modulation of Neuronal Functions

1987 • 87 citations

Gangliosides and cancer

1989 • 85 citations

Activation of the epidermal growth factor receptor tyrosine protein kinase in the absence of receptor oligomerization.

1988 • 84 citations

alpha-Thrombin-induced early mitogenic signalling events and G0 to S-phase transition of fibroblasts require continual external stimulation.

1985 • 83 citations

Sialidase activities of cultured human fibroblasts and the metabolism of GM3 ganglioside.

1988 • 83 citations

Glycosyltransferases: Do they exist on the surface membrane of mammalian cells?

1975 • 83 citations

Redistribution of mouse sperm surface galactosyltransferase after the acrosome reaction.

1987 • 82 citations

Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells

1989 • 81 citations

Gangliosides and Modulation of Neuronal Functions

1991 • 80 citations

Characteristic expression of glycosphingolipid profiles in the bipotential cell differentiation of human promyelocytic leukemia cell line HL-60

1984 • 77 citations

Enzymatic synthesis of N,N-dimethyl-sphingosine: Demonstration of the sphingosine: N-methyltransferase in mouse brain

1989 • 73 citations

The B cell antigen CD75 is a cell surface sialytransferase.

1990 • 67 citations

Growth control of human foreskin fibroblasts and inhibition of extracellular sialidase activity by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid.

1988 • 61 citations

Identification of cholera toxin binding glycoproteins in rat intestinal microvillus membranes.

1980 • 58 citations

Ganglioside-modulated protein phosphorylation. Partial purification and characterization of a ganglioside-inhibited protein kinase in brain.

1988 • 54 citations

Endogenous tumor lectins: overview and perspectives.

1986 • 46 citations

Murine monoclonal antibodies directed to the human histo-blood group A transferase (UDP-GalNAc:Fuc.alpha.1.fwdarw.2Gal .alpha.1.fwdarw.3-N-acetylgalactosaminyltransferase) and the presence therein of N-linked histo-blood group A determinant

1990 • 39 citations

Gangliosides modulate sodium transport in cultured toad kidney epithelia.

1986 • 38 citations

CDw17: a neutrophil glycolipid antigen regulated by activation.

1989 • 26 citations

Induction of astroglial growth inhibition and differentiation by sialosyl cholesterol

1989 • 17 citations

N‐Bromoacetyl‐amino‐cyanopindolol: a highly potent beta‐adrenergic affinity label blocks irreversibly a non‐protein component tightly associated with the receptor

1985 • 14 citations

Lack of suppression by gangliosides of humoral or cellular immunity in vivo

1989 • 11 citations

Quantification of ganglioside GM1 synthetase activity on intact chick neural retinal cells.

1982 • 9 citations